Drug & supplement interaction

Premorse + Propoxyphene

Propoxyphene brand names: Darvon, Prophene-65, Margesic, Davon.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Premorse and Propoxyphene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Premorse and Propoxyphene

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Propoxyphene and Premorse in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Premorse at all — not against Propoxyphene, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Premorse safety at a glance

Premorse overall Not established There is very little reliable human safety data for this herb.
Pregnancy Avoid Safety is not established, so avoid use during pregnancy.
Breastfeeding Avoid Safety is not established, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Propoxyphene and Premorse? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Propoxyphene’s Own FDA Label Lists

This is not an interaction — none of it involves Premorse. These are the most notable effects listed in the ADVERSE REACTIONS section of Propoxyphene’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Trouble swallowing Worth acting on
  • High blood sugar Worth acting on
  • Fainting Worth acting on
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on
  • Seizures Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Shortness of breath Worth acting on

Showing the 10 most notable of 36 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Propoxyphene. Read the label on DailyMed › Premorse’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Premorse side to compare — that is a limit of the record, not a statement that Premorse has no side effects.

Everything else you take

See Every Supplement That Interacts With Propoxyphene

This page covers Premorse only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propoxyphene page lists 172 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 141 moderate · 23 minor.

From our pharmacist’s overview on the Propoxyphene page

“Propoxyphene (Darvon) is an opioid painkiller, and the biggest hazard among the 172 supplement interactions on file is anything else that slows the brain and breathing. Seventy-eight of these ingredients pile on that sedation, alcohol and kava among the worst rated, and with an opioid the combination can push breathing dangerously low.”

Reviewed by 2 · Jul 18, 2026

Open the Propoxyphene interaction page

How much people look this up

Where Premorse and Propoxyphene Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Premorse
Steady interest

#778 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Propoxyphene
Top 5%

#65 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Premorse is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Premorse reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Premorse and Propoxyphene records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Premorse

What is Premorse?

Premorse
  • Coughs and respiratory complaints
  • Common cold and sore throat
  • Skin conditions
  • Digestive upset
  • Mild calming aid

Premorse (devil's-bit scabious) is a traditional European herb used for coughs, colds, and skin problems, but there is very little modern scientific research to confirm it works or is safe. Because evidence is so limited, it is best to talk with a pharmacist or doctor before using it, and to avoid it during pregnancy and breastfeeding.

Succisa pratensis · Caprifoliaceae · Roots, leaves, and flowering tops · Tea, tincture, dried herb, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Premorse is a good idea for someone in your situation. Here is what our Premorse record says about it on its own.

Premorse: dosing

There is no established or standardized dose for Premorse. Because it has not been studied in proper clinical trials, no reliable safe and effective amount has been determined.If you choose to use a commercial product, follow the directions on the label and do not take more than recommended. It is a good idea to review the product with a pharmacist first, since strength and quality can vary a lot between brands. When trying any new herb, starting low and watching for any reaction is a sensible approach.

From our Premorse monograph — the full record covers uses, side effects and every documented interaction.

Read the full Premorse monograph & all interactions
Medication

About Acetaminophen, Butalbital, and Caffeine

What Is Acetaminophen, Butalbital, and Caffeine Used For?

Brand names: Darvon, Prophene-65, Margesic, Davon

This three-ingredient combination — butalbital, acetaminophen, and caffeine — is used to relieve the symptoms of tension headache (also called muscle contraction headache). All supported products, including tablets, capsules, and oral solution, share this same approved use.

It is worth knowing that evidence for using this combination to treat repeated, frequent tension headaches over time is limited. Because butalbital can be habit-forming, extended or repeated use is not recommended.

See full Acetaminophen, Butalbital, and Caffeine drug information
Keep checking

Other Drugs & Premorse

Browse every other medication we’ve checked against Premorse — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Premorse against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Premorse list.

See the full Premorse interactions page
See every supplement checked against Propoxyphene, ranked by severity
Evidence & sources

Premorse References

The 3 sources that drive our Premorse monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Premorse is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbal Supplements — MedlinePlus Source
  3. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Premorse and Propoxyphene Together: Common Questions

Is it safe to take Premorse with Propoxyphene?
We do not list a known interaction between Premorse and Propoxyphene. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Propoxyphene interact with any supplements?
Yes. Propoxyphene has documented interactions with 172 supplements in our database — Premorse is not one of them. The Propoxyphene interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Premorse monograph Uses, safety profile, and every drug interaction in one place Acetaminophen, Butalbital, and Caffeine drug information The full plain-English guide to this medication Propoxyphene supplement interactions Every supplement checked against Propoxyphene, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Propoxyphene and Premorse?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.