Salatrim + Propoxyphene
Propoxyphene brand names: Darvon, Prophene-65, Margesic, Davon.
We found no known interaction between Salatrim and Propoxyphene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Salatrim and Propoxyphene
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Propoxyphene and Salatrim in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Salatrim at all — not against Propoxyphene, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Salatrim safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Propoxyphene
This page covers Salatrim only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propoxyphene page lists 172 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 8 major · 141 moderate · 23 minor.
From our pharmacist’s overview on the Propoxyphene page
“Propoxyphene (Darvon) is an opioid painkiller, and the biggest hazard among the 172 supplement interactions on file is anything else that slows the brain and breathing. Seventy-eight of these ingredients pile on that sedation, alcohol and kava among the worst rated, and with an opioid the combination can push breathing dangerously low.”
Reviewed by 2 · Jul 18, 2026
Where Salatrim and Propoxyphene Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#860 of 1,452 supplements looked up here in the last 7 days
#65 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Salatrim is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Salatrim reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Salatrim and Propoxyphene records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Salatrim
What is Salatrim?
- Reduced-calorie fat replacement in foods
- Lower-calorie baked goods and confections
- Reducing dietary fat calories
- Food texture and mouthfeel similar to regular fat
Salatrim is a man-made, reduced-calorie fat used as an ingredient in processed foods, not a traditional herb or supplement you would take on its own. It is designed to provide fewer calories than ordinary fat, but eating large amounts may cause stomach and bowel discomfort. If you have questions about products containing it, check the food label and ask your pharmacist or doctor.
Not applicable (manufactured fat ingredient) · Reduced-fat or reduced-calorie processed foods such as baked goods, chocolate, confections, and dairy-type products
An interaction check asks whether these two react with each other — it does not ask whether Salatrim is a good idea for someone in your situation. Here is what our Salatrim record says about it on its own.
Salatrim: dosing
There is no established supplement dose for Salatrim, because it is a food ingredient rather than a pill or capsule you would take by itself. The amount you get depends on the food product and how much of it you eat.If you choose foods made with Salatrim, follow the serving sizes listed on the food label and avoid eating very large amounts at once to lower the chance of digestive upset.
From our Salatrim monograph — the full record covers uses, side effects and every documented interaction.
About Acetaminophen, Butalbital, and Caffeine
What Is Acetaminophen, Butalbital, and Caffeine Used For?
Brand names: Darvon, Prophene-65, Margesic, Davon
This three-ingredient combination — butalbital, acetaminophen, and caffeine — is used to relieve the symptoms of tension headache (also called muscle contraction headache). All supported products, including tablets, capsules, and oral solution, share this same approved use.
It is worth knowing that evidence for using this combination to treat repeated, frequent tension headaches over time is limited. Because butalbital can be habit-forming, extended or repeated use is not recommended.
Other Drugs & Salatrim
Browse every other medication we’ve checked against Salatrim — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Salatrim against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Abemaciclib ›
- Hydroxyurea ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Acetaminophen, Codeine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Salatrim list.
Salatrim References
The 2 sources that drive our Salatrim monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Salatrim is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Food Additives & Ingredients — U.S. Food and Drug Administration Source
- Fat Replacers — MedlinePlus Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Salatrim and Propoxyphene Together: Common Questions
Is it safe to take Salatrim with Propoxyphene?
Does Propoxyphene interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Propoxyphene and Salatrim?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.