Herb & supplement monograph

Methoxydienone Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Methoxydienone interacts with medications. The heart of this page is the interaction list — every drug Methoxydienone is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Methoxydienone is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with Methoxydienone

0 medications have a known interaction with Methoxydienone, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Methoxydienone. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Methoxydienone combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Methoxydienone: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

Methoxydienone is a synthetic steroid-like compound marketed in some bodybuilding and 'prohormone' supplements, not a natural herb. There is very little reliable human safety or effectiveness research, and steroid-related products carry real risks to the liver, hormones, and heart. We do not recommend it, and you should talk with a doctor or pharmacist before using any product that contains it.

Part used
Synthetic compound (not a plant part)
Common forms
Capsules, tablets, powders (often as part of 'prohormone' or bodybuilding blends)
People commonly use it for
  • Muscle building
  • Strength gains
  • Bodybuilding supplement stacks
  • Athletic performance

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

It is a poorly studied synthetic steroid-like compound with potential hormonal and liver risks.

PregnancyPossibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including red...

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including red...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Methoxydienone is a synthetic, steroid-like chemical, not a plant or herb. It is sometimes called a 'prohormone' or 'designer steroid' and has appeared in dietary supplements sold for bodybuilding and athletic performance.

Because it is man-made, it does not come from a plant and is not grown anywhere. It is usually found inside multi-ingredient supplement blends marketed to people who want to build muscle or increase strength.

Products containing compounds like this are not well regulated, and their actual contents and amounts may not match the label. Some 'prohormone' ingredients have been the target of regulatory action in various countries.

Uses & effectiveness

People mainly use methoxydienone hoping to build muscle, gain strength, or improve athletic performance. These are popular, not proven, uses.

The honest answer is that there is very little reliable human research on methoxydienone for any purpose. Most of what is known comes from chemistry analyses of supplements and from how similar steroid-like molecules behave, not from well-designed clinical trials. There is not enough good evidence to say it works or is safe.

Because of the lack of quality studies and the potential for serious side effects, we cannot recommend it for any use.

How it works

Methoxydienone has a chemical structure related to steroid hormones. Compounds in this family are thought to interact with hormone pathways in the body, which is why they are marketed for muscle building.

The exact way methoxydienone acts in humans is not clearly established. Much of the reasoning is based on its similarity to other anabolic steroids and on laboratory analysis rather than careful studies in people.

Steroid-like substances can disrupt the body's natural hormone balance, which is one reason they are linked to side effects involving the liver, cholesterol, and the body's own testosterone and estrogen levels.

Safety & precautions

We treat methoxydienone as a product to avoid because it is poorly studied and belongs to a class of compounds known for safety concerns. Steroid-like supplements have been linked to liver injury, unhealthy cholesterol changes, hormonal imbalance, and heart-related risks.

People with liver disease, heart disease, hormone-sensitive conditions, high blood pressure, or those under 18 should not use it. Athletes should also be aware that such compounds may be banned in competitive sports and can cause a failed drug test.

Pregnancy and breastfeeding: Do not use methoxydienone if you are pregnant, may become pregnant, or are breastfeeding. Steroid-like compounds can affect a developing baby and may pass into breast milk, and there is no safety data to support its use.

Always talk with a doctor or pharmacist before taking any supplement that lists this ingredient.

Side effects

Because methoxydienone is not well studied, its full side-effect profile is unknown. Based on similar steroid-like compounds, possible effects include:

  • Liver stress or injury (which can be serious)
  • Unfavorable changes in cholesterol
  • Hormonal changes, such as reduced natural testosterone, acne, hair changes, or breast tissue changes in men
  • Mood changes, headache, or fatigue
  • Increased blood pressure or strain on the heart

Seek medical care right away if you notice yellowing of the skin or eyes, dark urine, severe abdominal pain, chest pain, or unusual swelling.

Dosing

There is no established or safe dose of methoxydienone. It has not been tested in proper clinical trials to determine a recommended amount.

Supplement labels that include it may suggest a dose, but these are not backed by solid safety research and product contents may be inaccurate. We do not provide a dose for it.

The safest choice is to avoid it. If you are considering any product that lists this ingredient, check with a pharmacist or doctor first.

Pregnancy & Breastfeeding

Methoxydienone & Pregnancy

Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100.

Methoxydienone & Breastfeeding

Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Methoxydienone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Methoxydienone

1 brand in our database make a supplement containing Methoxydienone.

Product directory

Supplement products with Methoxydienone

1 product in our database contain Methoxydienone. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Methoxydienone: Common Questions

Does Methoxydienone interact with prescription medications?
We do not currently list any known drug interactions for Methoxydienone. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Methoxydienone interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Methoxydienone with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Methoxydienone interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Methoxydienone a natural herb?
No. It is a synthetic, steroid-like chemical sometimes added to bodybuilding or 'prohormone' supplements. It does not come from a plant.
Is Methoxydienone safe to take?
It is poorly studied and belongs to a class of compounds linked to liver, hormone, and heart problems, so we recommend avoiding it. Talk to a healthcare provider before using any product that contains it.
Can it cause a failed drug test in sports?
Possibly. Steroid-like and 'prohormone' compounds are often banned in competitive sports, so using a product with Methoxydienone could lead to a positive test.
Can I take it while pregnant or breastfeeding?
No. Steroid-like compounds can harm a developing baby and may pass into breast milk, and there is no safety data, so it should be avoided.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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