Drug & supplement interaction

Arum + Propoxyphene

Propoxyphene brand names: Darvon, Prophene-65, Margesic, Davon.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Arum and Propoxyphene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Arum and Propoxyphene

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Propoxyphene and Arum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Arum safety at a glance

Arum overall Avoid The raw plant is toxic and irritating, and safe doses have not been established.
Pregnancy Likely Unsafe When used orally because of its toxicity; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally because of its toxicity; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Propoxyphene and Arum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Propoxyphene

Interactions in our licensed database are recorded against drug classes, not just single drug names. Propoxyphene is filed under 7 classifications — including narcotic drugs, cytochrome p450 2d6 (cyp2d6) inhibitors, cytochrome p450 2d6 (cyp2d6) substrates. Arum has documented interactions with 1 drug class — the most serious being iron (minor) — and none of Propoxyphene’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Arum Does Interact With Other Medications

Arum has 1 minor known drug interaction in our database — Propoxyphene isn’t one of them. If you take anything else, check it against the full list below.

Minor 1 No known interaction 2,829 (incl. Propoxyphene)
Taking anything else?

Check Another of Your Medications Against Arum

Covers the 2,830 medications we’ve checked against Arum. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Arum and Propoxyphene May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Arum

    “Orally, arum has been reported to cause burning of the oral mucous membranes, likely due to its oxalate crystal content. The immediate burning sensation caused by arum is thought to limit its oral intake, possibly reducing the likelihood for arum toxicity. Arum has also been reported to cause bloody vomiting, bloody diarrhea, and swelling of the tongue, lips, and palate in some people (18,32466).”

    Arum · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 101417. Prakash Raju KNJ, Goel K, Anandhi D, Pandit VR, Surendar R, Sasikumar M. Wild tuber poisoning: Arum maculatum - A rare case report. Int J Crit Illn Inj Sci. 2018;8(2):111-114. PubMed
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 32466. Mrvos, R., Dean, B. S., and Krenzelok, E. P. Philodendron/dieffenbachia ingestions: are they a problem? J Toxicol Clin Toxicol 1991;29(4):485-491. PubMed

    Propoxyphene

    Listed in the ADVERSE REACTIONS section of the FDA label for Propoxyphene. Read the label on DailyMed ›

Reported for Arum but not commonly for Propoxyphene: diarrhea and swelling.

Effects for Propoxyphene come from the ADVERSE REACTIONS section of its FDA label; effects for Arum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Arum in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally because of its toxicity; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Propoxyphene

This page covers Arum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propoxyphene page lists 172 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 141 moderate · 23 minor.

From our pharmacist’s overview on the Propoxyphene page

“Propoxyphene (Darvon) is an opioid painkiller, and the biggest hazard among the 172 supplement interactions on file is anything else that slows the brain and breathing. Seventy-eight of these ingredients pile on that sedation, alcohol and kava among the worst rated, and with an opioid the combination can push breathing dangerously low.”

Reviewed by 2 · Jul 18, 2026

Open the Propoxyphene interaction page

How much people look this up

Where Arum and Propoxyphene Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Arum
Steady interest

#1,037 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Propoxyphene
Top 5%

#82 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Arum and Propoxyphene records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Arum

What is Arum?

Arum
  • Coughs and chest congestion
  • Sore throat
  • Promoting sweating (diaphoretic)
  • Skin and wart remedies (topical folk use)
  • Digestive complaints

Arum is a traditional European plant whose root has been used in folk medicine, but there is essentially no reliable human research to support any health benefit. The raw plant is toxic and irritating because of calcium oxalate crystals, so it should not be eaten or used casually. We do not recommend using Arum as a supplement, especially during pregnancy or breastfeeding.

Arum maculatum · Araceae · Root (tuber), and sometimes leaves · Dried root preparations, tinctures, and traditional folk remedies

An interaction check asks whether these two react with each other — it does not ask whether Arum is a good idea for someone in your situation. Here is what our Arum record says about it on its own.

Arum: dosing

There is no established or standardized safe dose for Arum. Because the plant is toxic and human research is lacking, no trustworthy dosing guidelines exist.We do not recommend taking Arum. If you encounter a product that contains it, do not use it without first checking with a pharmacist or doctor, and never prepare or eat the raw plant yourself.

From our Arum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Arum monograph & all interactions
Medication

About Acetaminophen, Butalbital, and Caffeine

What Is Acetaminophen, Butalbital, and Caffeine Used For?

Brand names: Darvon, Prophene-65, Margesic, Davon

This three-ingredient combination — butalbital, acetaminophen, and caffeine — is used to relieve the symptoms of tension headache (also called muscle contraction headache). All supported products, including tablets, capsules, and oral solution, share this same approved use.

It is worth knowing that evidence for using this combination to treat repeated, frequent tension headaches over time is limited. Because butalbital can be habit-forming, extended or repeated use is not recommended.

See full Acetaminophen, Butalbital, and Caffeine drug information
Keep checking

Other Drugs & Arum

Browse every other medication we’ve checked against Arum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
1Minor
2,828No known interaction
1 Minor 2,828 No interaction
Minor

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Arum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Arum list.

See the full Arum interactions page
See every supplement checked against Propoxyphene, ranked by severity
Evidence & sources

Arum References

The 3 references that drive our Arum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Mrvos, R., Dean, B. S., and Krenzelok, E. P. Philodendron/dieffenbachia ingestions: are they a problem? J Toxicol Clin Toxicol 1991;29(4):485-491. PubMed
  3. Prakash Raju KNJ, Goel K, Anandhi D, Pandit VR, Surendar R, Sasikumar M. Wild tuber poisoning: Arum maculatum - A rare case report. Int J Crit Illn Inj Sci. 2018;8(2):111-114. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Arum and Propoxyphene Together: Common Questions

Is it safe to take Arum with Propoxyphene?
We do not list a known interaction between Arum and Propoxyphene. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Arum and Propoxyphene have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Arum and Propoxyphene combination checked?
Interactions in our licensed database are recorded against drug classes. Propoxyphene is filed under 7 classifications, and Arum has documented interactions with 1 drug class — none of Propoxyphene's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Arum interact with any other medications?
Yes. Arum has 1 documented drug interaction in our database — Propoxyphene is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Propoxyphene interact with any supplements?
Yes. Propoxyphene has documented interactions with 172 supplements in our database — Arum is not one of them. The Propoxyphene interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Arum monograph Uses, safety profile, and every drug interaction in one place Acetaminophen, Butalbital, and Caffeine drug information The full plain-English guide to this medication Propoxyphene supplement interactions Every supplement checked against Propoxyphene, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Propoxyphene and Arum?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.