Sumbul Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Sumbul interacts with medications. The heart of this page is the interaction list — every drug Sumbul is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Sumbul is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Sumbul against your medication
Add one medicationDrugs that interact with Sumbul
0 medications have a known interaction with Sumbul, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Sumbul. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Sumbul combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Sumbul: Uses, Safety & Side Effects
Sumbul is a musky-smelling root from a Ferula plant that has been used in traditional medicine mainly as a calming, antispasmodic remedy. There is very little modern scientific research to confirm any of its benefits, and its safety has not been well studied. Talk with a pharmacist or doctor before using it.

- Scientific name
- Ferula sumbul
- Family
- Apiaceae
- Part used
- Root (rhizome)
- Common forms
- Tincture, fluid extract, dried root, powder
- Nervous tension and anxiety
- Muscle spasms and cramps
- Menstrual discomfort
- Digestive upset
- Traditional aphrodisiac
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Little modern safety data exists, so use cautiously and under professional guidance.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailWhen sumbul leaves are used orally. After a breastfeeding parent consumed sumbul leaves, both the parent and breastfeeding infant experienced several...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Sumbul, also called musk root, comes from the root of a plant in the Ferula family (often listed as Ferula sumbul). These plants grow in parts of Asia and Europe, including regions of Central Asia and Russia.
The root has a strong, musky smell, which is why it earned the nickname "musk root." Historically, herbalists and traditional medicine systems used Sumbul as a calming remedy and to ease muscle spasms. It was once included in some older pharmacy texts and remedies.
Today Sumbul is uncommon and is mostly found as a tincture, fluid extract, or dried root rather than as a mainstream supplement.
Uses & effectiveness
People have traditionally used Sumbul as a sedative (to calm nerves), as an antispasmodic (to relax cramping muscles), and for menstrual or digestive discomfort. It has also been used as a folk aphrodisiac.
The evidence is very limited. Most of what we know comes from old herbal traditions, not from well-designed human studies. There are no strong clinical trials showing that Sumbul reliably treats anxiety, muscle spasms, or any other condition.
Because of this lack of modern research, Sumbul should not be relied on in place of treatments that are proven to work. If you have a health problem, talk with a healthcare professional about options that have better evidence behind them.
How it works
The musky odor of Sumbul comes from aromatic compounds and essential oils in the root, along with resins and gums. Some traditional sources suggest these compounds may have a relaxing or calming effect on the nervous system and on smooth muscle.
It is important to understand that these proposed actions are based mostly on traditional use and limited laboratory observations rather than solid human research. The exact active ingredients and how they might affect the body are not well understood.
Safety & precautions
The safety of Sumbul has not been carefully studied in modern times. Because we do not have good data, it is best to be cautious.
Pregnancy and breastfeeding: Avoid Sumbul. Other plants in the Ferula family have been linked to effects on the uterus, and there is not enough information to consider it safe for a developing baby or a nursing infant.
People with liver problems, those taking sedatives, older adults, and anyone with a chronic illness should be especially careful and check with a pharmacist or doctor first. Stop using it and seek care if you have any unusual reaction.
Side effects
Because Sumbul has not been well studied, its full side effect profile is unknown. Possible effects, based on its traditional use as a sedative, could include drowsiness or stomach upset.
As with any plant product, allergic reactions are possible. The strong musky odor and aromatic oils may also irritate some people. Stop using it and get medical help right away if you notice signs of an allergic reaction, such as rash, swelling, or trouble breathing.
Sumbul: Reported Adverse Effects
Documented safety reports on Sumbul from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
There is currently a limited amount of information on the adverse effects of sumbul.
Serious Adverse Effects (Rare):
Orally: Vomiting requiring hospitalization in individuals consuming sumbul leaf.
Nausea and vomiting Gastrointestinal
Orally, ingestion of sumbul leaves may cause vomiting. In one case, a mother and nursing infant presented to the emergency department after experiencing several episodes of vomiting two hours after the mother consumed sumbul leaves and later nursed the infant. The amount of sumbul leaves consumed was not reported. Both patients recovered without medication and were discharged 5 hours later, although the infant did require intravenous fluids.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no standardized, well-established dose for Sumbul. Historical doses were given as tinctures or fluid extracts, but those figures come from old herbal references and may not be safe or reliable today.
If you choose to use a Sumbul product, follow the directions on the label and do not exceed them. Because product quality and strength can vary widely, talk with a pharmacist before starting, and start with the lowest amount possible.
Sumbul & Pregnancy
Sumbul & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 references that drive our Sumbul monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Derin H, Yildirim G, Çaksen H. Intoxication from Ferula sumbul leaves in a mother and her infant. J Pediatr Intensive Care 2013;2(4):193-4.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Sumbul
1 brand in our database make a supplement containing Sumbul.
Supplement products with Sumbul
4 products in our database contain Sumbul. Open any to see its full ingredient list and every drug interaction we check.
Sumbul: Common Questions
Does Sumbul interact with prescription medications?
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Where does this Sumbul interaction information come from?
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Is Sumbul safe?
Can I take Sumbul while pregnant or breastfeeding?
Why does Sumbul smell like musk?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Sumbul
A rotating sample of real supplements in our database that list Sumbul — open any to see its full ingredients and every drug interaction we check.
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