Partridgeberry + Propoxyphene
Propoxyphene brand names: Darvon, Prophene-65, Margesic, Davon.
We found no known interaction between Partridgeberry and Propoxyphene in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Partridgeberry and Propoxyphene
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Propoxyphene and Partridgeberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Partridgeberry at all — not against Propoxyphene, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Partridgeberry safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Propoxyphene
This page covers Partridgeberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propoxyphene page lists 172 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 8 major · 141 moderate · 23 minor.
From our pharmacist’s overview on the Propoxyphene page
“Propoxyphene (Darvon) is an opioid painkiller, and the biggest hazard among the 172 supplement interactions on file is anything else that slows the brain and breathing. Seventy-eight of these ingredients pile on that sedation, alcohol and kava among the worst rated, and with an opioid the combination can push breathing dangerously low.”
Reviewed by 2 · Jul 18, 2026
Where Partridgeberry and Propoxyphene Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,302 of 1,452 supplements looked up here in the last 7 days
#63 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Partridgeberry is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Partridgeberry reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Partridgeberry and Propoxyphene records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Partridgeberry
What is Partridgeberry?
- Toning the uterus in late pregnancy (traditional)
- Menstrual cramps and painful periods
- Supporting childbirth and labor (traditional)
- Urinary and bladder discomfort
- Digestive complaints
Partridgeberry (Mitchella repens) is a traditional North American herb most often used as a so-called 'uterine tonic' near the end of pregnancy and for menstrual discomfort. There is very little modern scientific research to confirm any of these uses, and because it has traditionally been used to affect the uterus, it should not be used during pregnancy without medical guidance. Talk to your pharmacist or doctor before trying it.
Mitchella repens · Rubiaceae · Leaves and aerial parts (whole herb), sometimes berries · Tea, tincture, capsules, dried herb
An interaction check asks whether these two react with each other — it does not ask whether Partridgeberry is a good idea for someone in your situation. Here is what our Partridgeberry record says about it on its own.
Partridgeberry: dosing
There is no established, scientifically supported dose for partridgeberry. Traditional preparations were made as teas or tinctures, but standardized dosing based on modern research does not exist.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount. When in doubt, use the lowest amount suggested and consult a healthcare professional.
From our Partridgeberry monograph — the full record covers uses, side effects and every documented interaction.
About Acetaminophen, Butalbital, and Caffeine
What Is Acetaminophen, Butalbital, and Caffeine Used For?
Brand names: Darvon, Prophene-65, Margesic, Davon
This three-ingredient combination — butalbital, acetaminophen, and caffeine — is used to relieve the symptoms of tension headache (also called muscle contraction headache). All supported products, including tablets, capsules, and oral solution, share this same approved use.
It is worth knowing that evidence for using this combination to treat repeated, frequent tension headaches over time is limited. Because butalbital can be habit-forming, extended or repeated use is not recommended.
Other Drugs & Partridgeberry
Browse every other medication we’ve checked against Partridgeberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Partridgeberry against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Partridgeberry list.
Partridgeberry References
The 2 sources that drive our Partridgeberry monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Partridgeberry is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
- Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Partridgeberry and Propoxyphene Together: Common Questions
Is it safe to take Partridgeberry with Propoxyphene?
Does Propoxyphene interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.