New Zealand Green-lipped Mussel + Oxycodone
Oxycodone brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, and others.
We found no known interaction between New Zealand Green-lipped Mussel and Oxycodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Oxycodone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
New Zealand Green-lipped Mussel and Oxycodone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Oxycodone and New Zealand Green-lipped Mussel in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for New Zealand Green-lipped Mussel at all — not against Oxycodone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
New Zealand Green-lipped Mussel safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
New Zealand Green-lipped Mussel in Pregnancy & Breastfeeding
When used orally; avoid using. It may cause retarded fetal development and delay in parturition.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Oxycodone Products Have a Food Rule — New Zealand Green-lipped Mussel Should Not Break It
At least one FDA label for a product containing Oxycodone says to take it with food. If you take New Zealand Green-lipped Mussel on an empty stomach out of habit, keep them separate — and take Oxycodone with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Oxycodone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.2 , 5.1 , 5.2 , 5.3 ) XTAMPZA ER is administered, twice daily, every 12 hours, and must be taken with food .
From the Dosage and Administration section of the FDA label we read for Oxycodone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About New Zealand Green-lipped Mussel or Oxycodone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers New Zealand Green-lipped Mussel or Oxycodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- How Much Oxycodone is in a 10 mg Oxycodone Hydrochloride Tablet? ›
- How Long Should You Wait Between Metaxalone and Oxycodone? ›
- My Doctor Is Switching Me From Belbuca To Subutex For Pain ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Oxycodone
This page covers New Zealand Green-lipped Mussel only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxycodone page lists 145 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 8 major · 114 moderate · 23 minor.
From our pharmacist’s overview on the Oxycodone page
“Oxycodone is a potent opioid painkiller, and anything that deepens its sedation can slow breathing itself, which is why this list deserves genuine respect. Of the 145 supplement and herbal ingredients on record, eight rate major, and the biggest cluster by far, 78 ingredients, adds extra drowsiness on top of the opioid's own.”
Reviewed by 2 · Jul 18, 2026
Taking New Zealand Green-lipped Mussel as Part of a Dietary Supplement Product? Check It for Interactions
We hold 107 real supplement products containing New Zealand Green-lipped Mussel, each one broken down to its full ingredient list — and combination products often carry several ingredients besides New Zealand Green-lipped Mussel. Even though New Zealand Green-lipped Mussel itself has no known interaction with Oxycodone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where New Zealand Green-lipped Mussel and Oxycodone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#799 of 1,452 supplements looked up here in the last 7 days
#879 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every New Zealand Green-lipped Mussel reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The New Zealand Green-lipped Mussel and Oxycodone records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About New Zealand Green-lipped Mussel
What is New Zealand Green-lipped Mussel?
- Osteoarthritis joint pain
- Rheumatoid arthritis symptoms
- Joint stiffness and mobility
- General anti-inflammatory support
- Mild asthma support
New Zealand green-lipped mussel is a shellfish-derived supplement rich in omega-3 fats that is mostly used for joint pain and arthritis. Some studies suggest a modest benefit for osteoarthritis, but the evidence is mixed and not strong. It is generally well tolerated in healthy adults, but people with shellfish allergy should avoid it, and pregnant or breastfeeding people should not use it without medical advice.
Perna canaliculus · Mytilidae · Edible mussel flesh (often as a freeze-dried powder or lipid/oil extract) · Capsules, softgels (lipid extract), powder, tablets
An interaction check asks whether these two react with each other — it does not ask whether New Zealand Green-lipped Mussel is a good idea for someone in your situation. Here is what our New Zealand Green-lipped Mussel record says about it on its own.
New Zealand Green-lipped Mussel: dosing
There is no official or standardized dose for green-lipped mussel, and products vary widely in strength and form (powder versus lipid extract). Because of this, the best approach is to follow the directions on the product label.Dosing depends on whether you are using a whole-mussel powder or a concentrated oil extract, so the amounts are not interchangeable.
From our New Zealand Green-lipped Mussel monograph — the full record covers uses, side effects and every documented interaction.
About Oxycodone
What Is Oxycodone Used For?
Brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, OxyNeo
Oxycodone treats pain that is severe enough to need an opioid pain medicine, when other treatments are not enough. Other options include non-opioid pain relievers or opioid combination products.
Some products are for specific situations. Extended-release products (OxyContin, Xtampza ER, and oxycodone extended-release tablets) are for severe, persistent pain that needs daily, around-the-clock treatment. They are not for as-needed use. The 100 mg per 5 mL (20 mg/mL) oral solution is only for opioid-tolerant patients. Oxaydo is labeled for acute and chronic pain.
Other Drugs & New Zealand Green-lipped Mussel
Browse every other medication we’ve checked against New Zealand Green-lipped Mussel — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked New Zealand Green-lipped Mussel against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Sertraline ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Warfarin Sodium ›
- Amlodipine Besylate ›
- Methamphetamine ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Prednisone ›
- Metformin ›
- Amitriptyline ›
- Valacyclovir ›
- Tadalafil ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Lisdexamfetamine ›
- Amphetamine ›
- Propranolol ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Bendamustine ›
- Acetaminophen, Aspirin, Caffeine ›
- Naproxen ›
- Lamotrigine ›
- Quetiapine ›
- Acyclovir ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full New Zealand Green-lipped Mussel list.
New Zealand Green-lipped Mussel References
The 12 references that drive our New Zealand Green-lipped Mussel monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Miller T, Wu H. In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. N Z Med J 1984;97:355-7.
- Gibson SLM, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial. Complement Ther Med 1998;6:122-6.
- Gibson RG, Gibson SL, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner 1980;224:955-60.
- Fabrin, B. [Possible toxic hepatitis after intake of an alternative preparation]. Ugeskr.Laeger 6-13-1988;150(24):1474-1475.
- Gibson, R. G. and Gibson, S. L. Green-lipped mussel extract in arthritis. Lancet 2-21-1981;1(8217):439. PubMed
- Ahern, M. J., Milazzo, S. C., and Dymock, R. Granulomatous hepatitis and Seatone. Med J Aust 8-9-1980;2(3):151-152. PubMed
- Croft, J. E. Granulomatous hepatitis and Seatone. Med J Aust 10-4-1980;2(7):401-402. PubMed
- Lau, S., Chiu, P. K., Chu, E. M. Y., Cheng, I. Y. W., Tang, W. M., Man, R. Y. K., and Halpern, G. M. Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study. Progress in Nutrition
- Gruenwald, J., Graubaum, H., Hansen, K., and Grube, B. Efficacy and tolerability of a combination of LYPRINOL and high concentrations of EPA and DHA in inflammatory rheumatoid disorders... eicosapentaenoic acid... decosahexaenoid acid. Advances in Therap PubMed
- Coulson S, Vecchio P, Gramotnev H, Vitetta L. Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study. Inflammopharmacology 2012;20:71-6. PubMed
- Sukumaran S, Pittman KB, Patterson WK, et al. A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer. Ann Oncol 2010;2 PubMed
- Lello J, Liang A, Robinson E, et al. Treatment of children's asthma with a lipid extract of the new Zealand green lipped mussel (Perna canaliculus) (Lyprinol®)-A double blind, randomized controlled trial in children with moderate to serve chronic obstruct
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking New Zealand Green-lipped Mussel and Oxycodone Together: Common Questions
Is it safe to take New Zealand Green-lipped Mussel with Oxycodone?
Do New Zealand Green-lipped Mussel and Oxycodone have any of the same side effects?
Should I take New Zealand Green-lipped Mussel and Oxycodone at the same time of day?
Does Oxycodone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.