Drug & supplement interaction

Angelica Archangelica + Maprotiline

Maprotiline brand name: Ludiomil.

Moderate Interaction
Medically reviewed by · Updated February 2024
The bottom line Moderate

Angelica Archangelica has a moderate interaction with Maprotiline. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Angelica Archangelica and Maprotiline

Here is the interaction we found between these two, with the evidence behind it.

Moderate

Photosensitizing Drugs

Why this applies to Maprotiline

Maprotiline falls under Photosensitizing Drugs — the group Angelica Archangelica interacts with.

Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions. It is advised that patients using Angelica archangelica in any form should avoid prolonged exposure to sunlight. When combined with photosensitizing drugs like doxycycline, there is an elevated risk of photosensitivity reactions. Patients should be cautioned to take appropriate sun protection measures and monitor for any signs of skin irritation or photosensitivity when using these substances concomitantly. (Source: https://pubmed.ncbi.nlm.nih.gov/10630112/)
Severity Moderate Likelihood Possible Evidence C

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: this isn't about how your body breaks down maprotiline. Instead, it's about your skin and the sun. Maprotiline can make your skin more sensitive to sunlight on its own, and Angelica archangelica contains natural compounds called furanocoumarins that do the same thing. Stack the two together and you may sunburn faster or break out in a rash after even modest time outdoors.

This is rated as a possible, moderate concern with fairly limited evidence, so don't panic. If you use this herb in any form (taken by mouth or on your skin), be smart about sun protection: sunscreen, a hat, and covering up. Watch for redness or irritation, and check with your pharmacist or doctor before mixing the two.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Angelica Archangelica Also Interacts With Other Medications

Angelica Archangelica has 334 moderate known drug interactions in our database — the Maprotiline one above is one of them. If you take anything else, check it against the full list below.

Moderate 334 No known interaction 2,496 (incl. Maprotiline)
Taking anything else?

Check Another of Your Medications Against Angelica Archangelica

Covers the 2,830 medications we’ve checked against Angelica Archangelica. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Maprotiline

This page covers Angelica Archangelica only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Maprotiline page lists 116 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 1,3-dmaa (moderate), 5-htp (moderate) and Acacia Rigidula (moderate).

By severity: 2 major · 90 moderate · 24 minor.

From our pharmacist’s overview on the Maprotiline page

“The riskiest pairing on this page belongs to lithium. Taken alongside a serotonergic antidepressant like maprotiline (Ludiomil), it can both mask and raise the odds of serotonin syndrome, a dangerous buildup of serotonin activity, and it earns one of the list's two major ratings for that reason.”

Reviewed by 2 · Jul 18, 2026

Open the Maprotiline interaction page

How much people look this up

Where Angelica Archangelica and Maprotiline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Angelica Archangelica
Steady interest

#1,231 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Maprotiline
Steady interest

#2,575 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Angelica Archangelica

What is Angelica Archangelica?

Angelica Archangelica
  • Digestive upset and gas
  • Loss of appetite
  • Anxiety and restlessness
  • Mild respiratory complaints
  • Flavoring in foods and drinks

Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs. Solid human evidence for its health benefits is limited, and its skin-sensitizing furanocoumarins mean caution is warranted. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Read the full Angelica Archangelica monograph & all interactions
Medication

About Maprotiline

What Is Maprotiline Used For?

Brand name: Ludiomil

  • Maprotiline is used to treat depression, bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods), and anxiety. Maprotiline is in a class of medications called tetracyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.

See full Maprotiline drug information
Keep checking

Other Drugs & Angelica Archangelica

Browse every other medication we’ve checked against Angelica Archangelica — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
334Moderate
0Minor
2,495No known interaction
334 Moderate 2,495 No interaction
Moderate

334 interactions

Showing 60 of 334 moderate interactions — see all 334 on the Angelica Archangelica page.

No interaction 2,495 drugs checked — show the list

We also checked Angelica Archangelica against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,495 medications checked with no known interaction — see the full Angelica Archangelica list.

See the full Angelica Archangelica interactions page
See every supplement checked against Maprotiline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Angelica Archangelica monograph › Uses, safety, and every drug interaction in one place Maprotiline supplement interactions › Every supplement checked against Maprotiline, ranked by severity Maprotiline drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Angelica Archangelica and Maprotiline Together: Common Questions

Can you take Angelica Archangelica with Maprotiline?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Angelica Archangelica and Maprotiline interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Maprotiline and Angelica Archangelica?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.