Medication interaction hub

What Supplements Interact with Perphenazine?

Perphenazine brand name: Trilafon. Every interaction below applies to the brands too.

147 Interactions 5 Major 108 Moderate 34 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Perphenazine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Perphenazine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Perphenazine (Trilafon) treats schizophrenia and severe nausea, and this list deserves real care. Five of the 147 ingredients on file rate major, and those five are the ones to understand first. Activated charcoal can soak up the medication before your body absorbs it, and henbane piles drying, constipating, confusing anticholinergic effects on top of perphenazine's own. Two rauwolfia herbs may intensify both its effects and its side effects.

The other 108 moderate and 34 minor entries mostly follow a few patterns. Sixty ingredients use the same liver enzyme that clears perphenazine, so blood levels of one or the other can drift. Twenty add sun sensitivity, something phenothiazines like this one already cause. A handful, goldenseal among them, slow how perphenazine breaks down and can push its level up. If any of the five majors sits in your medicine cabinet, talk with your pharmacist before you combine them.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 108 Minor 34 No known interaction 1,305

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Perphenazine: Top Interactions at a Glance

The most significant Perphenazine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 147 interacting ingredients — plus 1,305 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Perphenazine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Perphenazinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Henbane + Perphenazinei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Indian Snakeroot + Perphenazinei

Theoretically, concomitant use might increase the risk of adverse effects.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Perphenazinei

Theoretically, concomitant use might increase the risk of adverse effects.

Read the full interaction Major Likelihood Probable Scopolia + Perphenazinei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction
The complete list

Every Supplement Checked Against Perphenazine

All 1,452 ingredients in our database, ranked by severity — 147 with a Perphenazine interaction on file and 1,305 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Perphenazine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cola Nut with Perphenazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, phenothiazines might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Perphenazine answer

Can you take Cocoa with Perphenazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, phenothiazines might increase the levels and adverse effects of caffeine.

Full Cocoa + Perphenazine answer

Can you take Bishop's Weed with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Perphenazine answer

Can you take Active Hexose Correlated Compound (ahcc) with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.

Full Active Hexose Correlated Compound (ahcc) + Perphenazine answer

Can you take Alfalfa with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + Perphenazine answer

Can you take Angel's Trumpet with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may increase anticholinergic effects and adverse effects.

Full Angel's Trumpet + Perphenazine answer

Can you take Angelica Archangelica with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Full Angelica Archangelica + Perphenazine answer

Can you take Arrach with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photos...

Full Arrach + Perphenazine answer

Can you take Bacopa with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might decrease the effectiveness of both agents.

Full Bacopa + Perphenazine answer

Can you take Berberine with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.

Full Berberine + Perphenazine answer

Can you take Beta-methylphenethylamine (bmpea) with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.

Full Beta-methylphenethylamine (bmpea) + Perphenazine answer

Can you take Biofeedback with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Perphenazine answer

Can you take Black Cohosh with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.

Full Black Cohosh + Perphenazine answer

Can you take Black Currant with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black currant seed oil might increase the risk of seizure in patients receiving phenothiazines.

Full Black Currant + Perphenazine answer

Can you take Black Pepper with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.

Full Black Pepper + Perphenazine answer

Can you take Borage with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.

Full Borage + Perphenazine answer

Can you take Boswellia Serrata with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.

Full Boswellia Serrata + Perphenazine answer

Can you take Boxwood with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Full Boxwood + Perphenazine answer

Can you take Cajeput Oil with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%.

Full Cajeput Oil + Perphenazine answer

Can you take Calamus with Perphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Perphenazine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Perphenazine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Perphenazine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Perphenazine sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Perphenazine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Perphenazine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Perphenazine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Perphenazine through this category.

Phenothiazines 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Perphenazine through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Perphenazine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Perphenazine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Perphenazine through this category.

About Perphenazine

Perphenazine is an antipsychotic medication used to treat schizophrenia and to control severe nausea and vomiting in adults.

Generic name: Perphenazine  ·  Brand name: Trilafon.

See the full Perphenazine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Perphenazine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Perphenazine.

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Pharmacist Counseling Corner

Perphenazine & Supplements: Common Questions

What supplements interact with Perphenazine?
More than you might expect — 147 in total, though they are far from equal: 5 are rated major, 108 moderate, and 34 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Henbane, Indian Snakeroot.
Which Perphenazine supplement interactions are the most serious?
The 5 major-rated combinations — led by Activated Charcoal, Henbane, Indian Snakeroot, Rauvolfia Vomitoria and Scopolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Perphenazine?
Usually yes — most people on Perphenazine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Trilafon have the same supplement interactions as Perphenazine?
Yes — Trilafon all contain Perphenazine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Perphenazine and my other medications?
This page covers Perphenazine against supplements and herbal ingredients. Checking Perphenazine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Perphenazine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.