Smartweed + Perphenazine
Perphenazine brand name: Trilafon.
We found no known interaction between Smartweed and Perphenazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Smartweed and Perphenazine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Perphenazine and Smartweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Smartweed safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Perphenazine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Perphenazine is filed under 8 classifications — including phenothiazines, antipsychotic drugs, cytochrome p450 2d6 (cyp2d6) inhibitors. Smartweed has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Perphenazine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Smartweed Does Interact With Other Medications
Smartweed has 2 moderate known drug interactions in our database — Perphenazine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Smartweed
We haven’t checked that one against Smartweed yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Smartweed. Pick one to open its full report.
See Every Supplement That Interacts With Perphenazine
This page covers Smartweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Perphenazine page lists 147 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Henbane (major), Indian Snakeroot (major), Rauvolfia Vomitoria (major) and Scopolia (major).
By severity: 5 major · 108 moderate · 34 minor.
From our pharmacist’s overview on the Perphenazine page
“Perphenazine (Trilafon) treats schizophrenia and severe nausea, and this list deserves real care. Five of the 147 ingredients on file rate major, and those five are the ones to understand first.”
Reviewed by 2 · Jul 18, 2026
Taking Smartweed as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4 real supplement products containing Smartweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Smartweed. Even though Smartweed itself has no known interaction with Perphenazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Smartweed and Perphenazine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#858 of 1,452 supplements looked up here in the last 7 days
#1,872 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Smartweed reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Smartweed and Perphenazine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Smartweed
What is Smartweed?
- Digestive upset
- Minor skin irritation
- Heavy menstrual bleeding (traditional)
- Wound and bleeding (traditional topical use)
- Antioxidant and anti-inflammatory support
Smartweed (Persicaria hydropiper) is a peppery wetland plant with a long history in traditional medicine for digestive complaints, bleeding, and skin problems. Modern human studies are very limited, so its benefits are not well proven. Because safety data are thin, it's best to use cautiously and avoid it during pregnancy and breastfeeding.
Persicaria hydropiper · Polygonaceae · Aerial parts (leaves, stems, and flowering tops); sometimes the whole plant · Tea, tincture, liquid extract, dried herb, and topical preparations
An interaction check asks whether these two react with each other — it does not ask whether Smartweed is a good idea for someone in your situation. Here is what our Smartweed record says about it on its own.
Smartweed: dosing
There is no well-established or standardized dose for smartweed. Because it has not been carefully studied in people, experts cannot recommend a safe and effective amount.If you choose to use a product, follow the directions on the label and do not exceed them.
From our Smartweed monograph — the full record covers uses, side effects and every documented interaction.
About Perphenazine
What Is Perphenazine Used For?
Brand name: Trilafon
Perphenazine tablets are approved to treat schizophrenia in adults. They are also used to control severe nausea and vomiting in adults when other measures are not enough.
Perphenazine has not been shown effective for managing behavioral problems in patients with intellectual disabilities, and it is not approved for dementia-related psychosis in elderly patients.
Other Drugs & Smartweed
Browse every other medication we’ve checked against Smartweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Smartweed against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Lisinopril ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Smartweed list.
Smartweed References
The 2 references that drive our Smartweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Smartweed and Perphenazine Together: Common Questions
Is it safe to take Smartweed with Perphenazine?
How was the Smartweed and Perphenazine combination checked?
Does Smartweed interact with any other medications?
Does Perphenazine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.