Perphenazine

71 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Fentanyl Transdermal Patch Lenvatinib Histrelin Implant Moxifloxacin
2 Contraindicated 67 Major 2 Moderate
All (71) Contraindicated (2) Major (67) Moderate (2)

Contraindicated

Perphenazine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Perphenazine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Perphenazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Perphenazine Sertraline Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Perphenazine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Perphenazine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Perphenazine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Perphenazine Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Perphenazine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Perphenazine Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Perphenazine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Perphenazine Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Perphenazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Perphenazine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Perphenazine Anagrelide Agrylin Increased risk of QT interval prolongation Details Perphenazine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Perphenazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Perphenazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Perphenazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Perphenazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Perphenazine Chloroquine Aralen® Increased risk of QT-interval prolongation Details Perphenazine Dasatinib Phyrago An increased risk of QT interval prolongation Details Perphenazine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Perphenazine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Perphenazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Perphenazine Diazepam Rectal Diastat Increased risk of CNS depression Details Perphenazine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Perphenazine Encorafenib Braftovi Increased risk of QT interval prolongation Details Perphenazine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Perphenazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Perphenazine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Perphenazine Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Perphenazine Fostemsavir Rukobia Increased risk of torsade de pointes Details Perphenazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Perphenazine Glasdegib Daurismo Increased risk of QT interval prolongation Details Perphenazine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Perphenazine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Perphenazine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Perphenazine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Perphenazine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.