Angel's Trumpet + Dexamethasone
Dexamethasone brand names: Decadron, Hexadrol, Dexone, Ozurdex, Dexycu, and others.
We found no known interaction between Angel's Trumpet and Dexamethasone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Angel's Trumpet and Dexamethasone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dexamethasone and Angel's Trumpet in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Angel's Trumpet safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Dexamethasone
Interactions in our licensed database are recorded against drug classes, not just single drug names. Dexamethasone is filed under 8 classifications — including corticosteroids, cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 3a4 (cyp3a4) inducers. Angel's Trumpet has documented interactions with 1 drug class — the most serious being anticholinergic drugs (moderate) — and none of Dexamethasone’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Angel's Trumpet Does Interact With Other Medications
Angel's Trumpet has 195 moderate known drug interactions in our database — Dexamethasone isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Angel's Trumpet
We haven’t checked that one against Angel's Trumpet yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Angel's Trumpet. Pick one to open its full report.
Angel's Trumpet in Pregnancy & Breastfeeding
When used orally. The entire plant is considered poisonous; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Angel's Trumpet or Dexamethasone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Angel's Trumpet or Dexamethasone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does Activated Charcoal Remove Dexamethasone From the Body? ›
- Can You Safely Use Flonase If You Have High Blood Pressure? ›
- Are Antibiotic Eye Drops Safe To Use In The Ear? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Dexamethasone
This page covers Angel's Trumpet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dexamethasone page lists 221 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).
By severity: 4 major · 182 moderate · 35 minor.
From our pharmacist’s overview on the Dexamethasone page
“People take dexamethasone for serious reasons, a chemotherapy course, an autoimmune flare, brain swelling, so I want anyone on it to give its 221 supplement interactions genuine attention, starting with the four rated major. Grapefruit and St.”
Reviewed by 2 · Jul 18, 2026
Taking Angel's Trumpet as Part of a Dietary Supplement Product? Check It for Interactions
We hold 3 real supplement products containing Angel's Trumpet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Angel's Trumpet. Even though Angel's Trumpet itself has no known interaction with Dexamethasone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Angel's Trumpet and Dexamethasone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,200 of 1,452 supplements looked up here in the last 7 days
#222 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angel's Trumpet reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Angel's Trumpet and Dexamethasone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Angel's Trumpet
What is Angel's Trumpet?
- Traditional folk medicine
- Asthma or breathing remedies (historical)
- Pain relief (traditional)
- Recreational hallucinogen (dangerous misuse)
- Ornamental garden plant
Angel's Trumpet is a highly poisonous ornamental plant that contains powerful toxins like scopolamine and atropine. There is no safe medicinal dose, and even small amounts can cause hallucinations, dangerous heart effects, coma, or death. It should not be taken as a supplement or remedy.
Brugmansia spp. · Solanaceae · Flowers, leaves, seeds, and roots (all parts are toxic) · Ornamental plant; rarely as teas, infusions, or smoked preparations (all unsafe)
An interaction check asks whether these two react with each other — it does not ask whether Angel's Trumpet is a good idea for someone in your situation. Here is what our Angel's Trumpet record says about it on its own.
Angel's Trumpet: dosing
There is no safe or established dose of Angel's Trumpet. The amount of toxin in the plant varies greatly from one plant, flower, or season to another, so even people who think they are using a "small" amount can be seriously poisoned.Because of these dangers, we cannot provide any dosing guidance, and we strongly advise against using this plant in any form.
From our Angel's Trumpet monograph — the full record covers uses, side effects and every documented interaction.
About Dexamethasone
What Is Dexamethasone Used For?
Brand names: Decadron, Hexadrol, Dexone, Ozurdex, Dexycu, Hemady, Dextenza
Dexamethasone is used to treat a wide range of conditions depending on the form and route. Oral tablets and solutions treat severe allergic reactions (such as asthma, contact dermatitis, and seasonal allergic rhinitis), inflammatory skin diseases, endocrine disorders including adrenal insufficiency and congenital adrenal hyperplasia, gastrointestinal diseases such as ulcerative colitis and regional enteritis, blood disorders, rheumatic conditions, kidney disease, and respiratory conditions including tuberculosis complications. Hemady (oral tablet) is specifically approved, in combination with other medicines, for multiple myeloma in adults. TaperDex (6-day and 12-day oral tablet packs) are used for the same broad range of allergic, inflammatory, and endocrine conditions.
Injectable forms (intramuscular and intravenous) are used when oral treatment is not possible, covering endocrine emergencies, shock, rheumatic disorders, and more. Eye-specific products treat different conditions: Dextenza (intracanalicular insert) treats eye inflammation and pain after eye surgery and itching from allergic conjunctivitis. Ozurdex (intravitreal implant) treats macular edema from retinal vein occlusion and diabetic macular edema, and non-infectious uveitis in the back of the eye. Dexycu (intraocular injection) treats inflammation after eye surgery. Maxidex (ophthalmic suspension) and dexamethasone sodium phosphate eye drops treat steroid-responsive inflammatory conditions of the eye. The ophthalmic/otic solution also treats steroid-responsive inflammation of the outer ear canal. A topical ointment (Seacall) is used for skin conditions including contact dermatitis, eczema, and neurodermatitis.
Most-Reported Side Effects for Dexamethasone
From FAERS, the FDA’s public side-effect reporting system (308,307 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Angel's Trumpet
Browse every other medication we’ve checked against Angel's Trumpet — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
195 interactions
- Diphenhydramine ›
- Glycopyrrolate ›
- Oxybutynin ›
- Ipratropium ›
- Procainamide ›
- Dimenhydrinate ›
- Lofepramine ›
- Nortriptyline ›
- Procyclidine ›
- Amantadine ›
- Desipramine ›
- Fluphenazine ›
- Hydroxyzine ›
- Hyoscyamine ›
- Meclizine ›
- Phenobarbital ›
- Scopolamine ›
- Trihexyphenidyl ›
- Trospium ›
- Atropine Sulfate ›
- Benztropine ›
- Biperiden ›
- Chlorpheniramine ›
- Chlorpromazine ›
- Clomipramine ›
- Clozapine ›
- Dexchlorpheniramine ›
- Disopyramide Phosphate ›
- Hyoscine Butylbromide ›
- Imipramine ›
- Loperamide ›
- Loxapine ›
- Prochlorperazine ›
- Propantheline ›
- Tolterodine ›
- Tripelennamine ›
- Acepromazine ›
- Aclidinium Bromide ›
- Aminoglutethimide ›
- Amitriptyline ›
- Atropine ›
- Belladonna Alkaloids (prescription Drug) ›
- Bromodiphenhydramine ›
- Buclizine ›
- Carbinoxamine Maleate ›
- Carphenazine ›
- Chlordiazepoxide ›
- Chlormezanone ›
- Chlorprothixene ›
- Clemastine ›
- Cyclizine ›
- Cyproheptadine ›
- Darifenacin ›
- Diphenylpyraline ›
- Doxylamine Succinate ›
- Ethopropazine ›
- Glutethimide ›
- Glycopyrronium Tosylate ›
- Hydrocodone/chlorpheniramine ›
- Letibotulinumtoxina-wlbg ›
Showing 60 of 195 moderate interactions — see all 195 on the Angel's Trumpet page.
No interaction 2,634 drugs checked — show the list
We also checked Angel's Trumpet against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Semaglutide ›
- Sumatriptan ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,634 medications checked with no known interaction — see the full Angel's Trumpet list.
Angel's Trumpet References
The 18 references that drive our Angel's Trumpet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
- McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
- Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4. PubMed
- Greene GS, Patterson SG, Warner E. Ingestion of angel's trumpet: an increasingly common source of toxicity. South Med J 1996;89:365-9. PubMed
- Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5. PubMed
- Gopel, C., Laufer, C., and Marcus, A. Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers. Nord.J.Psychiatry 2002;56(1):49-52. PubMed
- Havelius, U. and Asman, P. Accidental mydriasis from exposure to Angel's trumpet (Datura suaveolens). Acta Ophthalmol.Scand. 2002;80(3):332-335.
- Mobus, U., Demmler, G., and Schulz, K. [Accidental drowning due to tropane alkaloid abuse]. Arch Kriminol. 2002;210(1-2):16-21.
- Isbister, G. K., Oakley, P., Dawson, A. H., and Whyte, I. M. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg.Med.(Fremantle.) 2003;15(4):376-382.
- Marneros, A., Gutmann, P., and Uhlmann, F. Self-amputation of penis and tongue after use of Angel's Trumpet. Eur.Arch.Psychiatry Clin.Neurosci. 2006;256(7):458-459. PubMed
- Smith, E. A., Meloan, C. E., Pickell, J. A., and Oehme, F. W. Scopolamine poisoning from homemade 'moon flower' wine. J Anal.Toxicol 1991;15(4):216-219. DOI
- Hayman, J. Datura poisoning--the Angel's Trumpet. Pathology 1985;17(3):465-466. PubMed
- McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
- Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.
- Zhang HL, Wang XF. Angel's trumpet-associated polyneuropathy-is it Guillain-Barré syndrome? Pediatr Neurol. 2011 Jul;45(1):63; author reply 63-4. PubMed
- Sevketoglu E, Tatli B, Tugcu B, Demirelli Y, Hatipoglu S. An unusual cause of fulminant Guillain-Barré syndrome: angel's trumpet. Pediatr Neurol. 2010;43(5):368-70. PubMed
- Serin HM, Ozen B, Yilmaz S. A rare cause of acute anisocoria in a child: The angel's trumpet plant. J Pediatr Ophthalmol Strabismus. 2018;55:e33-e35. PubMed
- Colosimo E, Clodomiro A, Pirritano D, et al. Ischemic stroke and provoked seizure as a manifestation of Brugmansia suaveolens (angel's trumpet) acute intoxication: a detailed clinical, electroencephalogram, and magnetic resonance imaging description and 5
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Dexamethasone Is Linked to Lower Levels of 8 Nutrients
Natural Medicines records Dexamethasone as a medicine that can lower these. This is not an interaction with Angel's Trumpet — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Dexamethasone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Angel's Trumpet and Dexamethasone Together: Common Questions
Is it safe to take Angel's Trumpet with Dexamethasone?
Do Angel's Trumpet and Dexamethasone have any of the same side effects?
How was the Angel's Trumpet and Dexamethasone combination checked?
Does Angel's Trumpet interact with any other medications?
Does Dexamethasone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Dexamethasone and Angel's Trumpet?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.