Jimson Weed - Diclegis (Doxylamine Succinate, Pyridoxine Hydrochloride) Interaction

Interaction Details

Doxylamine Succinate, Pyridoxine Hydrochloride is classified as belonging to the following category: Anticholinergic Drugs

Theoretically, jimson weed may increase anticholinergic effects and adverse effects.
Jimson weed contains alkaloids with anticholinergic effects, such as atropine and scopolamine. Use with other anticholinergic drugs may cause additive effects.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
• Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
• Sasaki, T., Yamazaki, K., Yamori, T., and Endo, T. Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin. Br.J Cancer 10-7-2002;87(8):918-923.
• Al Shaikh, A. M. and Sablay, Z. M. Hallucinogenic plant poisoning in children. Saudi.Med.J 2005;26(1):118-121.
• Pavlov, A., Berkov, S., Weber, J., and Bley, T. Hyoscyamine Biosynthesis in Datura stramonium Hairy Root In Vitro Systems with Different Ploidy Levels. Appl Biochem Biotechnol 5-29-2008;
• Nogue, S., Pujol, L., Sanz, P., and de la, Torre R. Datura stramonium poisoning. Identification of tropane alkaloids in urine by gas chromatography-mass spectrometry. J Int Med.Res. 1995;23(2):132-137.
• Roblot, F., Montaz, L., Delcoustal, M., Gaboriau, E., Chavagnat, J. J., Morichaud, G., Pourrat, O., Scepi, M., and Patte, D. [Datura stramonium poisoning: the diagnosis is clinical, treatment is symptomatic]. Rev.Med.Interne 1995;16(3):187-190.

Doxylamine Succinate, Pyridoxine Hydrochloride Overview

• The combination of doxylamine and pyridoxine is used to treat nausea and vomiting in pregnant women whose symptoms have not improved after changing their diet or using other non-medicine treatments. Doxylamine is in a class of medications called antihistamines. It works by blocking the action of certain natural substances in the body that may contribute to nausea and vomiting. Pyridoxine (vitamin B₆) is a vitamin. It is given because a lack of pyridoxine in the body may also be a factor in causing nausea and vomiting during pregnancy.

Jimson Weed - More Interactions

Jimson Weed interacts with 193 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.