Drug & supplement interaction

Jimson Weed + Digoxin

Digoxin brand names: Lanoxicaps, Lanoxin, Digitek.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Jimson Weed and Digoxin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Jimson Weed and Digoxin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Digoxin and Jimson Weed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jimson Weed safety at a glance

Jimson Weed overall Avoid Jimson Weed is toxic and can cause life-threatening poisoning even at small doses.

Pregnancy Unsafe When used orally; avoid using. Read the full pregnancy detail

Breastfeeding Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Digoxin and Jimson Weed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Digoxin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Digoxin is filed under 5 classifications — including glucuronidated drugs, p-glycoprotein substrates, oral drugs. Jimson Weed has documented interactions with 1 drug class — the most serious being anticholinergic drugs (moderate) — and none of Digoxin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jimson Weed Does Interact With Other Medications

Jimson Weed has 195 moderate known drug interactions in our database — Digoxin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 195 No known interaction 2,635 (incl. Digoxin)

Taking anything else?

Check Another of Your Medications Against Jimson Weed

Covers the 2,830 medications we’ve checked against Jimson Weed. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jimson Weed and Digoxin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 4 of them are worth acting on rather than waiting out — marked below.

Hallucinations Worth acting on Additional detail
Jimson Weed
“Orally, jimson weed can block muscarinic cholinergic neurons and cause anticholinergic side effects. Larger amounts of jimson weed intake can also lead to toxicity and anticholinergic syndrome. Central anticholinergic symptoms, which are dose-dependent, include muscle tremor and rigidity, leg cramps, hallucinations, slurred speech, psychosis, agitated delirium, seizures, coma, cardiovascular collapse, or respiratory…”

Jimson Weed · Natural Medicines adverse-effect record, reported in arrhythmia.
6 sources cited

636. Hassell LH, MacMillan MW. Acute anticholinergic syndrome following ingestion of Angel's trumpet tea. Hawaii Med J 1995;54:669-70.

57067. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.

57075. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed

57077. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.

57078. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed

57084. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed
“Orally, jimson weed can cause anticholinergic side effects such as memory loss, attention impairment, confusion, hallucinations, slurred speech, psychosis, agitated delirium, seizures, and coma.”

Jimson Weed · Natural Medicines adverse-effect record, reported in epilepsy.
6 sources cited

57067. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.

57075. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed

57077. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.

57078. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed

57084. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed

57085. Parissis, D., Mellidis, C., Boutis, A., Apostolidis, K., Ignatiadis, M., Kiosses, V., and Milonas, I. Neurological findings in a case of coma secondary to Datura stramonium poisoning. Eur J Neurol. 2003;10(6):745-746.
Digoxin

Listed in the ADVERSE REACTIONS section of the FDA label for Digoxin. Read the label on DailyMed ›
An irregular heartbeat Worth acting on Additional detail
Jimson Weed
“Orally, jimson weed can cause anticholinergic side effects such as hypertension, tachycardia, and arrhythmia.”

Jimson Weed · Natural Medicines adverse-effect record, reported in arrhythmia.
6 sources cited

57099. Matsuda, K., Morinaga, M., Okamoto, M., Miyazaki, S., Isimaru, T., Suzuki, K., and Tohyama, K. [Toxicological analysis of a case of Datura stramonium poisoning]. Rinsho Byori 2006;54(10):1003-1007.

57156. Tiongson, J. and Salen, P. Mass ingestion of Jimson Weed by eleven teenagers. Del.Med.J 1998;70(11):471-476.

57067. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.

57103. Rwiza, H. T. Jimson weed food poisoning. An epidemic at Usangi rural government hospital. Trop.Geogr.Med. 1991;43(1-2):85-90.

57151. Dewitt, M. S., Swain, R., and Gibson, L. B., Jr. The dangers of jimson weed and its abuse by teenagers in the Kanawha Valley of West Virginia. W.V.Med J 1997;93(4):182-185.

57152. Amlo, H., Haugeng, K. L., Wickstrom, E., Koss, A., Husebye, T., and Jacobsen, D. [Poisoning with Jimson weed. Five cases treated with physostigmine]. Tidsskr.Nor Laegeforen. 8-10-1997;117(18):2610-2612.
Digoxin

Listed in the ADVERSE REACTIONS section of the FDA label for Digoxin. Read the label on DailyMed ›
Confusion Worth acting on Additional detail

Jimson Weed

“Orally, jimson weed is unsafe.

Most Common Adverse Effects:

Orally: Anticholinergic effects, such as abdominal pain, altered mental status, dry eyes, dry mouth, dry skin, nausea, tachycardia, urinary retention, and vomiting.

Serious Adverse Effects (Rare):

Orally: Anticholinergic toxicity, death.”

Jimson Weed · Natural Medicines adverse-effect record, reported in dry eye.

Digoxin

Listed in the ADVERSE REACTIONS section of the FDA label for Digoxin. Read the label on DailyMed ›
A low platelet count Worth acting on Additional detail
Jimson Weed
“Orally, jimson weed has been reported to cause thrombocytopenia in one patient.”

Jimson Weed · Natural Medicines adverse-effect record, reported in thrombocytopenia.
1 source cited

109502. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
Digoxin

Listed in the ADVERSE REACTIONS section of the FDA label for Digoxin. Read the label on DailyMed ›
Blurred vision Additional detail

Jimson Weed

Recorded for Jimson Weed in the same Natural Medicines adverse-effect record shown under Hallucinations above.

Digoxin

Listed in the ADVERSE REACTIONS section of the FDA label for Digoxin. Read the label on DailyMed ›
A fast or pounding heartbeat Additional detail

Jimson Weed

Recorded for Jimson Weed in the same Natural Medicines adverse-effect record shown under Confusion above.

Digoxin

Listed in the ADVERSE REACTIONS section of the FDA label for Digoxin. Read the label on DailyMed ›
Stomach pain / Vomiting / Nausea Additional detail
Jimson Weed
“Orally, jimson weed can cause anticholinergic side effects such as abdominal pain, nausea and vomiting, decreased bowel sounds, and difficulty swallowing (13,18,5623,109502,113142).”

Jimson Weed · Natural Medicines adverse-effect record, reported in nausea and vomiting.
5 sources cited

13. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

5623. Anon. Jimson weed poisoning- Texas, New York, and California, 1994. MMWR Morb Mortal Wkly Rep 1995;44:41-4.

109502. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.

113142. Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604. PubMed
Digoxin

Listed in the ADVERSE REACTIONS section of the FDA label for Digoxin. Read the label on DailyMed ›

Reported for Jimson Weed but not commonly for Digoxin: trouble swallowing, trouble passing urine, severe muscle breakdown and raised blood pressure.

Effects for Digoxin come from the ADVERSE REACTIONS section of its FDA label; effects for Jimson Weed come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Jimson Weed in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Jimson Weed or Digoxin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Jimson Weed or Digoxin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Digoxin

This page covers Jimson Weed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Digoxin page lists 113 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Aloe (major), Blue Flag (major), Danshen (major) and European Buckthorn (major).

By severity: 18 major · 79 moderate · 16 minor.

From our pharmacist’s overview on the Digoxin page

“Digoxin is a heart medicine with a narrow therapeutic index, meaning the gap between a helpful blood level and a harmful one is small, and few drugs give me more pause when supplements enter the picture. The most serious entries here are herbs that themselves contain digoxin-like cardiac glycosides, foxglove and lily-of-the-valley amon…”

Reviewed by 2 · Jul 18, 2026

Open the Digoxin interaction page

One more smart check

Taking Jimson Weed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Jimson Weed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jimson Weed. Even though Jimson Weed itself has no known interaction with Digoxin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jimson Weed and Digoxin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jimson Weed

Steady interest

#1,354 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Digoxin

Top 25%

#511 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jimson Weed reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Jimson Weed and Digoxin records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Jimson Weed

What is Jimson Weed?

Asthma and breathing problems (historical/folk use)
Pain relief
Recreational hallucinogen (highly dangerous misuse)
Muscle spasms
Skin conditions (traditional topical use)

Jimson Weed is a highly poisonous plant that contains powerful nerve-affecting compounds, and even small amounts can cause severe poisoning, hallucinations, or death. It is not a safe supplement, and there is no reliable evidence supporting its use for any health condition. Do not use Jimson Weed in any form.

Datura stramonium · Solanaceae · Leaves, seeds, flowers, and roots · Dried plant material, smoked preparations, teas, and folk extracts (none are recommended for self-use)

An interaction check asks whether these two react with each other — it does not ask whether Jimson Weed is a good idea for someone in your situation. Here is what our Jimson Weed record says about it on its own.

Jimson Weed: dosing

There is no safe or established dose of Jimson Weed. The amount of toxic alkaloids varies widely from plant to plant, season to season, and even between different parts of the same plant, so there is no way to take a predictable amount.Because of this, no responsible pharmacist or doctor recommends using it.

From our Jimson Weed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jimson Weed monograph & all interactions

Medication

About Digoxin

What Is Digoxin Used For?

Brand names: Lanoxicaps, Lanoxin, Digitek

Digoxin treats mild to moderate heart failure in adults. It improves heart failure symptoms and exercise capacity, and it reduces heart failure-related hospitalizations and emergency care. It does not change survival.

It also helps control the resting heart rate in adults with chronic atrial fibrillation (an irregular heartbeat). In children with heart failure, the tablet, oral solution and most injection products are used to increase the heart’s pumping strength (myocardial contractility). Some older injection labels list only the adult uses. Digoxin Oral Solution should not be used for multifocal atrial tachycardia.

See full Digoxin drug information

Keep checking

Other Drugs & Jimson Weed

Browse every other medication we’ve checked against Jimson Weed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

195Moderate

0Minor

2,634No known interaction

195 Moderate 2,634 No interaction

Moderate

195 interactions

Showing 60 of 195 moderate interactions — see all 195 on the Jimson Weed page.

No interaction 2,634 drugs checked — show the list

We also checked Jimson Weed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,634 medications checked with no known interaction — see the full Jimson Weed list.

See the full Jimson Weed interactions page

See every supplement checked against Digoxin, ranked by severity

Evidence & sources

Jimson Weed References

The 43 references that drive our Jimson Weed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
Hassell LH, MacMillan MW. Acute anticholinergic syndrome following ingestion of Angel's trumpet tea. Hawaii Med J 1995;54:669-70.
Urich RW, Bowerman DL, Levisky JA, Pflug JL. Datura stramonium: a fatal poisoning. J Forensic Sci 1982;27:948-54.
Anon. Jimson weed poisoning- Texas, New York, and California, 1994. MMWR Morb Mortal Wkly Rep 1995;44:41-4.
Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed
Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed
Sasaki, T., Yamazaki, K., Yamori, T., and Endo, T. Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin. Br.J Cancer 10-7-2002;87(8):918-923. PubMed
Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed
Parissis, D., Mellidis, C., Boutis, A., Apostolidis, K., Ignatiadis, M., Kiosses, V., and Milonas, I. Neurological findings in a case of coma secondary to Datura stramonium poisoning. Eur J Neurol. 2003;10(6):745-746.
Boumba, V. A., Mitselou, A., and Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Vet.Hum.Toxicol. 2004;46(2):81-82.
Steenkamp, P. A., Harding, N. M., van Heerden, F. R., and van Wyk, B. E. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci.Int 10-4-2004;145(1):31 PubMed
DeFrates, L. J., Hoehns, J. D., Sakornbut, E. L., Glascock, D. G., and Tew, A. R. Antimuscarinic intoxication resulting from the ingestion of moonflower seeds. Ann.Pharmacother. 2005;39(1):173-176. PubMed
Ertekin, V., Selimoglu, M. A., and Altinkaynak, S. A combination of unusual presentations of Datura stramonium intoxication in a child: rhabdomyolysis and fulminant hepatitius. J Emerg.Med. 2005;28(2):227-228. PubMed
Al Shaikh, A. M. and Sablay, Z. M. Hallucinogenic plant poisoning in children. Saudi.Med.J 2005;26(1):118-121. DOI
Forrester, M. B. Jimsonweed (Datura stramonium) exposures in Texas, 1998-2004. J Toxicol.Environ.Health A 2006;69(19):1757-1762.
Matsuda, K., Morinaga, M., Okamoto, M., Miyazaki, S., Isimaru, T., Suzuki, K., and Tohyama, K. [Toxicological analysis of a case of Datura stramonium poisoning]. Rinsho Byori 2006;54(10):1003-1007.
Rwiza, H. T. Jimson weed food poisoning. An epidemic at Usangi rural government hospital. Trop.Geogr.Med. 1991;43(1-2):85-90.
Diker, D., Markovitz, D., Rothman, M., and Sendovski, U. Coma as a presenting sign of Datura stramonium seed tea poisoning. Eur J Intern.Med. 2007;18(4):336-338. PubMed
Spina, S. P. and Taddei, A. Teenagers with Jimson weed (Datura stramonium) poisoning. CJEM. 2007;9(6):467-468. PubMed
Germond-Burquier, V., Narring, F., and Broers, B. [Intentional datura stramonium intoxication and circumstances of use in two adolescents]. Presse Med. 2008;37(6 Pt 1):982-985.
Pavlov, A., Berkov, S., Weber, J., and Bley, T. Hyoscyamine Biosynthesis in Datura stramonium Hairy Root In Vitro Systems with Different Ploidy Levels. Appl Biochem Biotechnol 5-29-2008; PubMed
Shervette, R. E., III, Schydlower, M., Lampe, R. M., and Fearnow, R. G. Jimson "loco" weed abuse in adolescents. Pediatrics 1979;63(4):520-523. DOI
O'Grady, T. C., Brown, J., and Jacamo, J. Outbreak of Jimson Weed abuse among Marine Corps personnel at Camp Pendleton. Mil.Med. 1983;148(9):732-734. DOI
Taha, S. A. and Mahdi, A. H. Datura intoxication in Riyadh. Trans.R.Soc.Trop.Med.Hyg. 1984;78(1):134-135. PubMed
Nogue, S., Pujol, L., Sanz, P., and de la, Torre R. Datura stramonium poisoning. Identification of tropane alkaloids in urine by gas chromatography-mass spectrometry. J Int Med.Res. 1995;23(2):132-137.
Roblot, F., Montaz, L., Delcoustal, M., Gaboriau, E., Chavagnat, J. J., Morichaud, G., Pourrat, O., Scepi, M., and Patte, D. [Datura stramonium poisoning: the diagnosis is clinical, treatment is symptomatic]. Rev.Med.Interne 1995;16(3):187-190.
Suda, K., Komatsu, K., and Hashimoto, K. A histopathological study on the islets of Langerhans and ductal epithelial metaplasia in atrophic lobuli of pancreas. Acta Pathol.Jpn. 1976;26(5):561-572. PubMed
Dewitt, M. S., Swain, R., and Gibson, L. B., Jr. The dangers of jimson weed and its abuse by teenagers in the Kanawha Valley of West Virginia. W.V.Med J 1997;93(4):182-185.
Amlo, H., Haugeng, K. L., Wickstrom, E., Koss, A., Husebye, T., and Jacobsen, D. [Poisoning with Jimson weed. Five cases treated with physostigmine]. Tidsskr.Nor Laegeforen. 8-10-1997;117(18):2610-2612.
Tiongson, J. and Salen, P. Mass ingestion of Jimson Weed by eleven teenagers. Del.Med.J 1998;70(11):471-476.
Adegoke SA, Alo LA. Datura stramonium poisoning in children. Niger J Clin Pract. 2013;16(1):116-8. PubMed
Melvin K, Hourani D. Datura stramonium toxicity mistakenly diagnosed as "bath salt" intoxication: a case report. W V Med J. 2014;110(1):22-5.
Özkaya AK, Güler E, Karabel N, Namli AR, Göksügür Y. Datura stramonium poisoning in a child. Turk J Pediatr. 2015;57(1):82-4.
Ricard F, Abe E, Duverneuil-Mayer C, Charlier P, de la Grandmaison G, Alvarez JC. Measurement of atropine and scopolamine in hair by LC-MS/MS after Datura stramonium chronic exposure. Forensic Sci Int. 2012;223(1-3):256-60. PubMed
Sanlidag B, Derinöz O, Yildiz N. A case of pediatric age anticholinergic intoxication due to accidental Datura stramonium ingestion admitting with visual hallucination. Turk J Pediatr. 2014;56(3):313-5.
Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
Mutebi RR, Ario AR, Nabatanzi M, et al. Large outbreak of Jimsonweed (Datura stramonium) poisoning due to consumption of contaminated humanitarian relief food: Uganda, March-April 2019. BMC Public Health 2022;22(1):623. PubMed
Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Digoxin Is Linked to Lower Levels of One Nutrient

Natural Medicines records Digoxin as a medicine that can lower these. This is not an interaction with Jimson Weed — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

MAGNESIUM›

Read the full Digoxin nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Jimson Weed and Digoxin Together: Common Questions

Is it safe to take Jimson Weed with Digoxin?

We do not list a known interaction between Jimson Weed and Digoxin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Jimson Weed and Digoxin have any of the same side effects?

Yes — our sources link each of them separately to 9 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Jimson Weed and Digoxin combination checked?

Interactions in our licensed database are recorded against drug classes. Digoxin is filed under 5 classifications, and Jimson Weed has documented interactions with 1 drug class — none of Digoxin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Jimson Weed interact with any other medications?

Yes. Jimson Weed has 195 documented drug interactions in our database — Digoxin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Digoxin interact with any supplements?

Yes. Digoxin has documented interactions with 113 supplements in our database — Jimson Weed is not one of them. The Digoxin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jimson Weed monograph Uses, safety profile, and every drug interaction in one place Digoxin drug information The full plain-English guide to this medication Digoxin supplement interactions Every supplement checked against Digoxin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 43 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Digoxin and Jimson Weed?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.