Medication interaction hub

What Supplements Interact with Digoxin?

Digoxin brand names: Lanoxicaps, Lanoxin, Digitek. Every interaction below applies to the brands too.

113 Interactions 18 Major 79 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Digoxin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Digoxin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Digoxin is a heart medicine with a narrow therapeutic index, meaning the gap between a helpful blood level and a harmful one is small, and few drugs give me more pause when supplements enter the picture. The most serious entries here are herbs that themselves contain digoxin-like cardiac glycosides, foxglove and lily-of-the-valley among them; adding one to a prescription is essentially double dosing. St. John's wort pulls the opposite way and can lower digoxin levels enough to weaken its effect.

Other entries work indirectly. Stimulant laxative herbs such as aloe latex can drain potassium, which leaves the heart more vulnerable to digoxin toxicity, and activated charcoal can soak up a dose before it ever absorbs, so space that sort of product well apart from your pill. Of the 113 ingredients on file, 18 rate major, 79 moderate, and 16 minor, and those 18 are where to start reading.

— , Clinical Pharmacist · July 18, 2026

Major 18 Moderate 79 Minor 16 No known interaction 1,339

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Digoxin: Top Interactions at a Glance

The Digoxin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 113 interacting ingredients — plus 1,339 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Digoxin Combinations Today

The Digoxin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Vitamin D + Digoxini

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.

Read the full interaction Moderate Likelihood Possible Lemongrass + Digoxini

Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.

Read the full interaction Moderate Likelihood Possible Cannabis + Digoxini

Theoretically, cannabis might alter levels of drugs that are substrates of P-glycoprotein (P-gp).

Read the full interaction Minor Likelihood Possible Marshmallow + Digoxini

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Read the full interaction Minor Likelihood Possible Grapefruit + Digoxini

Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Read the full interaction Moderate Likelihood Possible Calcium + Digoxini

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.

Read the full interaction
The complete list

Every Supplement Checked Against Digoxin

All 1,452 ingredients in our database, ranked by severity — 113 with a Digoxin interaction on file and 1,339 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Digoxin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin D with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.

Full Vitamin D + Digoxin answer

Can you take Lemongrass with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.

Full Lemongrass + Digoxin answer

Can you take Cannabis with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might alter levels of drugs that are substrates of P-glycoprotein (P-gp).

Full Cannabis + Digoxin answer

Can you take Marshmallow with Digoxin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Digoxin answer

Can you take Grapefruit with Digoxin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Full Grapefruit + Digoxin answer

Can you take Ginkgo with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with P-glycoprotein substrates might increase the levels and adverse effects of these substrates.

Full Ginkgo + Digoxin answer

Can you take Goli Apple Cider Vinegar Gummies with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It has been suggested that taking apple cider vinegar and digoxin at the same time may increase the likelihood of cardiac toxicity.

Full Goli Apple Cider Vinegar Gummies + Digoxin answer

Can you take Gossypol with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gossypol might increase the risk of digoxin toxicity due to the potassium-depleting effects of gossypol.

Full Gossypol + Digoxin answer

Can you take Green Tea with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea might increase the levels and adverse effects of P-glycoprotein (P-gp) substrates.

Full Green Tea + Digoxin answer

Can you take Guar Gum with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Digoxin answer

Can you take Gum Arabic with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Digoxin answer

Can you take Hawthorn with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hawthorn might potentiate the effects and adverse effects of digoxin.

Full Hawthorn + Digoxin answer

Can you take Hedge Mustard with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hedge mustard with digoxin might increase the risk of cardiac glycoside toxicity.

Full Hedge Mustard + Digoxin answer

Can you take Hesperidin with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of...

Full Hesperidin + Digoxin answer

Can you take Indian Long Pepper with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase levels of P-glycoprotein substrates.

Full Indian Long Pepper + Digoxin answer

Can you take Jalap with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Jalap has diuretic and stimulant laxative effects.

Full Jalap + Digoxin answer

Can you take Kaolin with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence is conflicting about the effect of kaolin on digoxin pharmacokinetics.

Full Kaolin + Digoxin answer

Can you take Kava with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.

Full Kava + Digoxin answer

Can you take Khella with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, khella might decrease the effectiveness of cardiac glycosides like digoxin.

Full Khella + Digoxin answer

Can you take Laminaria with Digoxin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, laminaria might increase the risk of hyperkalemia, which could increase the effects and adverse effects of digoxin.

Full Laminaria + Digoxin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Digoxin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Digoxin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Digoxin sits in 5 interaction categories. Open any one to see what the group means:

Digoxin (Lanoxin) 58 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

58 of the supplement ingredients on this page reach Digoxin through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Digoxin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Digoxin through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Digoxin through this category.

Digoxin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Digoxin through this category.

About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate.

Generic name: Digoxin  ·  Brand names: Lanoxicaps, Lanoxin, Digitek.

See the full Digoxin drug information

Related: does Digoxin deplete any nutrients?

Digoxin has 3 reported nutrient associations in the research literature — see the Digoxin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Digoxin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Digoxin.

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Pharmacist Counseling Corner

Digoxin & Supplements: Common Questions

What supplements interact with Digoxin?
In our interaction database, 113 supplement and herbal ingredients have an interaction with Digoxin on file — 18 rated major, 79 moderate, and 16 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Foxglove, Lily-of-the-valley, St. John's Wort.
Which Digoxin supplement interactions are the most serious?
Focus on the major group: Foxglove, Lily-of-the-valley, St. John's Wort, Swamp Milkweed and Uzara, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Digoxin?
That depends entirely on which supplement. The honest answer for Digoxin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Lanoxicaps have the same supplement interactions as Digoxin?
Yes — Lanoxicaps, Lanoxin, Digitek all contain Digoxin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Digoxin deplete any vitamins or nutrients?
It might — Digoxin has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Digoxin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Digoxin and my other medications?
This page covers Digoxin against supplements and herbal ingredients. Checking Digoxin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Digoxin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.