Medication interaction hub

What Supplements Interact with Dolutegravir?

Dolutegravir brand name: Tivicay. Every interaction below applies to the brands too.

65 Interactions 3 Major 46 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dolutegravir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dolutegravir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Dolutegravir (Tivicay) works only when its blood level stays high enough to keep HIV suppressed, so a supplement that drags that level down can let the virus rebound, and this list warrants genuine care. Three of the 65 entries are rated major. Calcium and activated charcoal can block the drug from being absorbed, and St. John's wort pushes it out of the body faster through a transporter called P-glycoprotein.

That transporter explains much of the rest, since 37 ingredients touch P-glycoprotein in some way, though nearly all sit in the moderate column (46 entries, plus 16 minor). Another 17, mostly charcoals and bulking fibers, can blunt absorption of anything swallowed, and a dozen affect glucuronidation, the breakdown route this drug relies on. The calcium interaction comes with a specific fix, taking dolutegravir 2 hours before or 6 hours after the supplement, and iron deserves the same spacing.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 46 Minor 16 No known interaction 1,387

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Dolutegravir: Top Interactions at a Glance

The most significant Dolutegravir supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 65 interacting ingredients — plus 1,387 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Dolutegravir + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Dolutegraviri

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Calcium + Dolutegraviri

Calcium seems to reduce levels of dolutegravir.

Read the full interaction Major Likelihood Probable St. John's Wort + Dolutegraviri

St.

Read the full interaction
The complete list

Every Supplement Checked Against Dolutegravir

All 1,452 ingredients in our database, ranked by severity — 65 with a Dolutegravir interaction on file and 1,387 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dolutegravir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Dolutegravir?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Calcium seems to reduce levels of dolutegravir.

Full Calcium + Dolutegravir answer

Can you take Iron with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Iron might decrease dolutegravir levels by reducing its absorption.

Full Iron + Dolutegravir answer

Can you take Algin with Dolutegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Dolutegravir answer

Can you take Gum Arabic with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Dolutegravir answer

Can you take Hesperidin with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of...

Full Hesperidin + Dolutegravir answer

Can you take Indian Long Pepper with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase levels of P-glycoprotein substrates.

Full Indian Long Pepper + Dolutegravir answer

Can you take Kava with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.

Full Kava + Dolutegravir answer

Can you take Lemongrass with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.

Full Lemongrass + Dolutegravir answer

Can you take Licorice with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.

Full Licorice + Dolutegravir answer

Can you take Methoxylated Flavones with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that some methoxylated flavones including tangeretin, nobiletin, and heptamethoxyflavone, inhibit P-glycoprotein.

Full Methoxylated Flavones + Dolutegravir answer

Can you take Milk Thistle with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Full Milk Thistle + Dolutegravir answer

Can you take Moringa with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Moringa + Dolutegravir answer

Can you take Neem with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Neem + Dolutegravir answer

Can you take Oregon Grape with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.

Full Oregon Grape + Dolutegravir answer

Can you take Quercetin with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of P-glycoprotein substrates.

Full Quercetin + Dolutegravir answer

Can you take Rabdosia Rubescens with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Rabdosia rubescens might increase levels of p-glycoprotein substrates.

Full Rabdosia Rubescens + Dolutegravir answer

Can you take Rhodiola with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Full Rhodiola + Dolutegravir answer

Can you take Sage with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase levels of drugs transported by P-glycoprotein.

Full Sage + Dolutegravir answer

Can you take Schisandra with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Full Schisandra + Dolutegravir answer

Can you take Slippery Elm with Dolutegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Dolutegravir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dolutegravir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dolutegravir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dolutegravir sits in 4 interaction categories. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Dolutegravir through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Dolutegravir through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Dolutegravir through this category.

Dolutegravir (Tivicay) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Dolutegravir through this category.

About Dolutegravir

Dolutegravir is an antiretroviral medicine used to treat HIV-1 infection in adults and eligible children, available as Tivicay and Tivicay PD.

Generic name: Dolutegravir  ·  Brand name: Tivicay.

See the full Dolutegravir drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dolutegravir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dolutegravir.

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Pharmacist Counseling Corner

Dolutegravir & Supplements: Common Questions

What supplements interact with Dolutegravir?
Our database currently documents 65 ingredients with a known Dolutegravir interaction (3 major, 46 moderate, 16 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 65. The highest-ranked right now: Activated Charcoal, Calcium, St. John's Wort.
Which Dolutegravir supplement interactions are the most serious?
The 3 major-rated combinations — led by Activated Charcoal, Calcium and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Dolutegravir?
Plenty of supplements coexist fine with Dolutegravir; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tivicay have the same supplement interactions as Dolutegravir?
Yes — Tivicay all contain Dolutegravir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Dolutegravir and my other medications?
This page covers Dolutegravir against supplements and herbal ingredients. Checking Dolutegravir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Dolutegravir drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.