Alpha-linolenic Acid (ala) + Dolutegravir
Dolutegravir brand name: Tivicay.
We found no known interaction between Alpha-linolenic Acid (ala) and Dolutegravir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Alpha-linolenic Acid (ala) and Dolutegravir
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dolutegravir and Alpha-linolenic Acid (ala) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Alpha-linolenic Acid (ala) at all — not against Dolutegravir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Alpha-linolenic Acid (ala) safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Alpha-linolenic Acid (ala) in Pregnancy & Breastfeeding
When used orally in amounts typically found in foods. There is insufficient reliable information available about the safety of alpha-linolenic acid during pregnancy and lactation when used in larger, medicinal amounts; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Dolutegravir Is Prescribed For, and What Alpha-linolenic Acid (ala) Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Dolutegravir is a prescription medicine with approved uses on its FDA label. Alpha-linolenic Acid (ala) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Dolutegravir is prescribed for: Tivicay and Tivicay PD are used to treat HIV-1 infection. They are always taken in combination with other antiretroviral medicines — they are not used alone. Both products are approved for adults (whether new to treatment or previously treated) and for children who have not previously been treated with an integrase inhibitor (INSTI). Tivicay (the standard tablet) has an additional use: it can be combined with rilpivirine as a complete two-drug regimen for adults whose HIV is already well controlled (virologically suppressed) on a stable treatment plan for at least 6 months, with no history of treatment failure or known resistance to either drug.
Alpha-linolenic Acid (ala) has been studied for:
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Cancer studied, not established Alpha-linolenic Acid (ala) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Alpha-linolenic Acid (ala) for cancer
It is unclear if increased dietary intake of alpha-linolenic acid affects mortality in patients with cancer.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Dolutegravir on your own; if you are taking Alpha-linolenic Acid (ala) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Dolutegravir
This page covers Alpha-linolenic Acid (ala) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dolutegravir page lists 65 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Calcium (major), St. John's Wort (major), Bitter Melon (moderate) and Black Pepper (moderate).
By severity: 3 major · 46 moderate · 16 minor.
From our pharmacist’s overview on the Dolutegravir page
“Dolutegravir (Tivicay) works only when its blood level stays high enough to keep HIV suppressed, so a supplement that drags that level down can let the virus rebound, and this list warrants genuine care. Three of the 65 entries are rated major.”
Reviewed by 2 · Jul 18, 2026
Where Alpha-linolenic Acid (ala) and Dolutegravir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,382 of 1,452 supplements looked up here in the last 7 days
#1,895 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-linolenic Acid (ala) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Alpha-linolenic Acid (ala) and Dolutegravir records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Alpha-linolenic Acid (ala)
What is Alpha-linolenic Acid (ala)?
- Heart health
- Source of omega-3 fats
- General wellness
- Inflammation
- Plant-based omega-3 alternative to fish oil
Alpha-linolenic acid (ALA) is an essential plant-based omega-3 fatty acid your body cannot make, so you must get it from food. It is found in flaxseed, walnuts, and certain vegetable oils, and most people benefit from including these foods as part of a balanced diet. ALA is generally safe from food, but talk to a pharmacist or doctor before taking high-dose supplements.
Seeds, nuts, and vegetable oils (dietary source) · Flaxseed oil, capsules, softgels, flaxseed, walnuts, canola and soybean oils
An interaction check asks whether these two react with each other — it does not ask whether Alpha-linolenic Acid (ala) is a good idea for someone in your situation. Here is what our Alpha-linolenic Acid (ala) record says about it on its own.
Alpha-linolenic Acid (ala): dosing
There is no single official supplement dose of ALA for treating health conditions.
From our Alpha-linolenic Acid (ala) monograph — the full record covers uses, side effects and every documented interaction.
About Dolutegravir
What Is Dolutegravir Used For?
Brand name: Tivicay
Tivicay and Tivicay PD are used to treat HIV-1 infection. They are always taken in combination with other antiretroviral medicines — they are not used alone. Both products are approved for adults (whether new to treatment or previously treated) and for children who have not previously been treated with an integrase inhibitor (INSTI).
Tivicay (the standard tablet) has an additional use: it can be combined with rilpivirine as a complete two-drug regimen for adults whose HIV is already well controlled (virologically suppressed) on a stable treatment plan for at least 6 months, with no history of treatment failure or known resistance to either drug.
Most-Reported Side Effects for Dolutegravir
From FAERS, the FDA’s public side-effect reporting system (19,465 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Alpha-linolenic Acid (ala)
Browse every other medication we’ve checked against Alpha-linolenic Acid (ala) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Alpha-linolenic Acid (ala) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Lisinopril ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Alpha-linolenic Acid (ala) list.
Alpha-linolenic Acid (ala) References
The 12 references that drive our Alpha-linolenic Acid (ala) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
- Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
- Crawford M, Galli C, Visioli F, et al. Role of Plant-Derived Omega-3 Fatty Acids in Human Nutrition. Ann Nutr Metab 2000;44:263-5. PubMed
- Connor WE. Alpha-linolenic acid in health and disease. Am J Clin Nutr 1999;69:827-8. PubMed
- Gibson RA, Makrides M. n-3 polyunsaturated fatty acid requirements of term infants. Am J Clin Nutr 2000;71:251S-5S. PubMed
- De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
- Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
- Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
- Leitzmann MF, Stampfer MJ, Michaud DS, et al. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr 2004;80:204-16. PubMed
- Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
- Chavarro JE, Stampfer MJ, Li H, et al. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2007;16:1364-70. PubMed
- Brouwer IA, Geleijnse JM, Klaasen VM, Smit LA, Giltay EJ, de Goede J, Heijboer AC, Kromhout D, Katan MB. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. PLoS One. 2013 Dec 11;8(1 PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Alpha-linolenic Acid (ala) and Dolutegravir Together: Common Questions
Is it safe to take Alpha-linolenic Acid (ala) with Dolutegravir?
Are Alpha-linolenic Acid (ala) and Dolutegravir used for the same thing?
Does Dolutegravir interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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