Apple Cider Vinegar - Lanoxin (Digoxin) Interaction

Interaction Details

Digoxin is classified as belonging to the following category: Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

Pharmacist Analysis

The supposed interaction between apple cider vinegar and digoxin, which is commonly mentioned in various online sources, is largely based on a single, isolated case documented in a 1998 issue of the journal Nephron.

The case involved a 28-year-old woman who consumed 250 ml of cider vinegar daily for a period of six years, leading to adverse health effects such as muscle cramps and hypokalemia.

The root cause of her symptoms was identified as excessive intake of acetic acid and its effect on renal excretion of bicarbonate, sodium, and potassium, causing depletion of arterial blood volume and mild hypokalemia.

It's important to note that this was an unusual situation where the individual consumed amounts of ACV far beyond normal levels and the information is only derived from a single case report, which is among the lowest level of evidence in medical literature. Case reports typically describe the experience of a single individual, and while they can provide valuable information about unusual or rare conditions, they cannot be used to establish cause-and-effect relationships or to make generalizations about a population.

Further research is required to validate the findings.

Source: Hypokalemia, Hyperreninemia and Osteoporosis in a Patient Ingesting Large Amounts of Cider Vinegar. Nephron. 1998 Oct;80(2):242-3.

References

• Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3.

Digoxin Overview

• Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate.

Apple Cider Vinegar - More Interactions

Apple Cider Vinegar interacts with 160 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.