Does Apple Cider Vinegar Interact With Cymbalta?

In our latest question and answer, the pharmacist discusses combining Cymbalta and apple cider vinegar.


Can I take Apple Cider Vinegar while using Cymbalta for fibromyalgia?

Asked by Val On Aug 21, 2023

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Aug 28, 2023
Last updated May 15, 2024

Key points

  • There is no known interaction between Cymbalta and apple cider vinegar.


Based on the evidence available to us, there is currently no significant clinical evidence to suggest a direct interaction between Cymbalta (duloxetine) and apple cider vinegar (ACV).

It's important to note that ACV does have some documented interactions with certain drugs, such as those that impact on blood sugar levels and potassium balance. However, the available data does not indicate a notable interaction between ACV and psychotropic medications like Cymbalta.

What Is Apple Cider Vinegar (ACV) And What Does It Interact With?

Apple cider vinegar (ACV) is a liquid made from fermented apple juice. It has gained popularity for its potential health benefits, such as aiding digestion, supporting weight management, and even having antibacterial properties. ACV contains acetic acid, which gives it its characteristic sour taste and is believed to be responsible for some of its effects.

While ACV has interactions with medications like insulin and certain diuretics due to its effects on blood sugar and potassium levels, the interactions are largely related to its influence on metabolic processes.

In the case of psychotropic medications like Cymbalta, which affects neurotransmitters in the brain, there is no substantial evidence to suggest that ACV directly interferes with its mechanism of action.

What Is Cymbalta (Duloxetine)?

Cymbalta (duloxetine) is a medication classified as a serotonin-norepinephrine reuptake inhibitor (SNRI).

It's commonly prescribed to manage conditions such as major depressive disorder, generalized anxiety disorder, and chronic pain disorders.

Cymbalta works by increasing the levels of certain neurotransmitters in the brain, which can have a positive impact on mood and pain perception.

Considering Safety and Individual Factors

While the current available information suggests that there is no significant interaction between ACV and Cymbalta, it's essential to remember that individual responses to medications and substances can vary.

Factors such as overall health, underlying medical conditions, and the specific formulation of ACV can play a role in how interactions might occur.

As always, be sure to speak with your doctor before making any changes to your medication regimen. 

Final Thoughts

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  • Safety and side effects of apple vinegar intake and its effect on metabolic parameters and body weight: a systematic review, PubMed
  • The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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