Can You Take Claritin And Benzonatate Together?

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Claritin and benzonatate together.


Can Claritin be taken with benzonatate?

Asked by EIleen On Mar 07, 2023

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Mar 15, 2023
Last updated Mar 15, 2023

Key points

  • There is no known interaction between the antihistamine Claritin (loratadine) and benzonatate.
  • Benzonatate has no known clinically significant drug interactions.

Quick Answer

There is no known interaction between Claritin (loratadine) and benzonatate. They are considered safe to take together.

Detailed Answer

Hello and thanks for contacting us!

Claritin (loratadine), a second-generation antihistamine, and benzonatate (generic for Tessalon), a cough suppressant, are typically considered safe to take together.

These drugs have different mechanisms of action and do not interact with each other in a way that can cause adverse effects, as far as is known.

In fact, benzonatate has no reported drug interactions listed in the FDA-approved prescribing information for the drug.

The lack of drug interactions with benzonatate is likely due to the fact that it does not affect CYP metabolizing enzymes in the liver, does not affect the absorption of other drugs, and is generally very well-tolerated at the usually prescribed dosages. It isn't thought to have any sort of additive effects when combined with Claritin.

If benzonatate has been prescribed to you and you are taking Claritin to help prevent allergies, you can feel safe using them together.

Final Words

Thanks so much for reaching out to us!

It's always a good idea to check into potential interactions, especially when OTC medications, like Claritin, are involved.

Fortunately, in this situation, there is no interaction to be concerned about.


  • Tessalon Prescribing Information, AccessFDA

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Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

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