Can You Take Claritin And Benzonatate Together?
In our latest question and answer, the pharmacist discusses whether or not it is safe to take Claritin and benzonatate together.

Question
Can Claritin be taken with benzonatate?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 18, 2025
Key points
- There is no known interaction between the antihistamine Claritin (loratadine) and benzonatate.
- Benzonatate has no known clinically significant drug interactions.
Quick Answer
There is no known interaction between Claritin (loratadine) and benzonatate. They are considered safe to take together.
Detailed Answer
Hello and thanks for contacting us!
Claritin (loratadine), a second-generation antihistamine, and benzonatate (generic for Tessalon), a cough suppressant, are typically considered safe to take together.
These drugs have different mechanisms of action and do not interact with each other in a way that can cause adverse effects, as far as is known.
In fact, benzonatate has no reported drug interactions listed in the FDA-approved prescribing information for the drug.
The lack of drug interactions with benzonatate is likely due to the fact that it does not affect CYP metabolizing enzymes in the liver, does not affect the absorption of other drugs, and is generally very well-tolerated at the usually prescribed dosages. It isn't thought to have any sort of additive effects when combined with Claritin.
If benzonatate has been prescribed to you and you are taking Claritin to help prevent allergies, you can feel safe using them together.
Final Words
Thanks so much for reaching out to us!
It's always a good idea to check into potential interactions, especially when OTC medications, like Claritin, are involved.
Fortunately, in this situation, there is no interaction to be concerned about.
References
- Tessalon Prescribing Information, AccessFDA
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Dr. Brian Staiger, PharmD
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