Can You Take Sudafed And Ibuprofen Together?

In our latest question and answer, the pharmacist discusses whether or not Sudafed can be taken with ibuprofen.

Question

I have mild arthritis and will take Advil to help. Can I mix it with Sudafed?

Asked by Bill On Nov 23, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Nov 23, 2022
Last updated May 07, 2024

Key points

  • There is no drug interaction between ibuprofen and Sudafed (pseudoephedrine). They are safe to take together.
  • There are several products available over-the-counter that contain both drugs in a single tablet.

Answer

Yes, it is safe to take Sudafed (pseudoephedrine) with Advil (ibuprofen). There is no drug interaction between them.

Sudafed PE (phenylephrine) is also safe to take with Advil.

Many Products Contain Both Ibuprofen And Nasal Decongestant

You didn't specify in your question if you are referring to Sudafed, which contains pseudoephedrine, or Sudafed PE, which contains phenylephrine.

Both are nasal decongestants, but pseudoephedrine needs to be purchased at the pharmacy counter with ID (due to The Combat Methamphetamine Epidemic Act of 2005).

Regardless of which product you are talking about, both are safe to take with ibuprofen (the active ingredient in Advil).

There are a number of products available over the counter that contain both pseudoephedrine and ibuprofen in a single tablet.

These products include:

  • Advil Cold & Sinus
  • CVS Cold & Sinus Relief
  • Premier Value Ibuprofen and Pseudoephedrine
  • Wal-Profen Cold and Sinus

Similarly, phenylephrine can be found with ibuprofen in several products, including:

  • Advil Multi-Symptom Cold & Flu

Final Words

If you are suffering from a cold or the flu, experiencing symptoms like nasal congestion and a sinus headache are common.

Combining ibuprofen and a nasal decongestant (like Sudafed) often represents a good therapy choice to help alleviate some of these symptoms and fortunately, there is no drug interaction to be concerned about.

Thanks for your question and reach back out anytime!

References

  • Combat Methamphetamine Epidemic Act, DEA
  • Pseudoephedrine Monograph, PubChem
  • Ibuprofen Monograph, PubChem

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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