Can You Take Sudafed And Ibuprofen Together?
In our latest question and answer, the pharmacist discusses whether or not Sudafed can be taken with ibuprofen.

Question
I have mild arthritis and will take Advil to help. Can I mix it with Sudafed?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 26, 2025
Key points
- There is no drug interaction between ibuprofen and Sudafed (pseudoephedrine). They are safe to take together.
- There are several products available over-the-counter that contain both drugs in a single tablet.
Answer
Yes, it is safe to take Sudafed (pseudoephedrine) with Advil (ibuprofen). There is no drug interaction between them.
Sudafed PE (phenylephrine) is also safe to take with Advil.
Many Products Contain Both Ibuprofen And Nasal Decongestant
You didn't specify in your question if you are referring to Sudafed, which contains pseudoephedrine, or Sudafed PE, which contains phenylephrine.
Both are nasal decongestants, but pseudoephedrine needs to be purchased at the pharmacy counter with ID (due to The Combat Methamphetamine Epidemic Act of 2005).
Regardless of which product you are talking about, both are safe to take with ibuprofen (the active ingredient in Advil).
There are a number of products available over the counter that contain both pseudoephedrine and ibuprofen in a single tablet.
These products include:
- Advil Cold & Sinus
- CVS Cold & Sinus Relief
- Premier Value Ibuprofen and Pseudoephedrine
- Wal-Profen Cold and Sinus
Similarly, phenylephrine can be found with ibuprofen in several products, including:
- Advil Multi-Symptom Cold & Flu
Final Words
If you are suffering from a cold or the flu, experiencing symptoms like nasal congestion and a sinus headache are common.
Combining ibuprofen and a nasal decongestant (like Sudafed) often represents a good therapy choice to help alleviate some of these symptoms and fortunately, there is no drug interaction to be concerned about.
Thanks for your question and reach back out anytime!
-
Dr. Brian Staiger, PharmD
- 16589 views