Can you take Benadryl with Xanax?

Thanks for reaching out to us!

There is a moderate interaction between Benadryl (diphenhydramine) and Xanax (alprazolam).

In most situations, Benadryl and Xanax should not be taken together due to the additive side effects that may occur. More specifically, both can cause drowsiness and sedation. Combining both can make you feel these effects more strongly.

What Is Xanax?

Xanax is classified as a benzodiazepine and, in terms of side effects, is well known to cause sedation, central nervous depression and at high doses, respiratory depression.

It is used for a variety of indications but is commonly used for anxiety disorders.

Xanax is a controlled substance and long-term use can cause dependence.

What Is Benadryl?

Benadryl is classified as a sedating, first-generation antihistamine.

Like Xanax, it can cause sedation and central nervous system depression. It does not commonly cause respiratory depression but it has been rarely reported.

Combining Xanax And Benadryl

Due to the additive effects of both drugs, coadministration can potentiate the effects of both, potentially increasing the risk of adverse effects.

Both Benadryl and Xanax are relatively short-acting so although you shouldn't take them together, you may be able to take them the same day.

The effects of Benadryl last anywhere from 4 to 8 hours per dose while Xanax can last from 8 to 12 hours per dose. Whenever combining new medications, it is important to let your doctor know.

Lastly, if you are simply looking for an effective antihistamine that can be safely taken with Xanax, you could try a second-generation antihistamine such as Claritin or Allegra. These are non-drowsy and do not interact with Xanax.