Lactoferrin + Digoxin
Digoxin brand names: Lanoxicaps, Lanoxin, Digitek.
We found no known interaction between Lactoferrin and Digoxin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Lactoferrin and Digoxin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Digoxin and Lactoferrin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Lactoferrin at all — not against Digoxin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Lactoferrin safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Lactoferrin in Pregnancy & Breastfeeding
When used orally in amounts commonly found in foods. Lactoferrin has Generally Regarded as Safe (GRAS) status in the US.
When used orally in medicinal amounts. Lactoferrin has been used with apparent safety during the second or third trimester of pregnancy at doses of up to 250 mg daily for up to 8 weeks. Also, bovine lactoferrin has been used with apparent safety throughout all trimesters of pregnancy at doses of up to 200 mg daily. There is insufficient reliable information available about the safety of intravaginal lactoferrin during pregnancy and lactation; avoid using.
When used orally in amounts commonly found in foods. Lactoferrin has Generally Regarded as Safe (GRAS) status in the US. There is insufficient reliable information available about the safety of lactoferrin when used medicinally during lactation; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Lactoferrin or Digoxin
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lactoferrin or Digoxin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Digoxin
This page covers Lactoferrin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Digoxin page lists 113 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Aloe (major), Blue Flag (major), Danshen (major) and European Buckthorn (major).
By severity: 18 major · 79 moderate · 16 minor.
From our pharmacist’s overview on the Digoxin page
“Digoxin is a heart medicine with a narrow therapeutic index, meaning the gap between a helpful blood level and a harmful one is small, and few drugs give me more pause when supplements enter the picture. The most serious entries here are herbs that themselves contain digoxin-like cardiac glycosides, foxglove and lily-of-the-valley amon…”
Reviewed by 2 · Jul 18, 2026
Taking Lactoferrin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 292 real supplement products containing Lactoferrin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lactoferrin. Even though Lactoferrin itself has no known interaction with Digoxin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Lactoferrin and Digoxin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#522 of 1,452 supplements looked up here in the last 7 days
#337 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lactoferrin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Lactoferrin and Digoxin records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Lactoferrin
What is Lactoferrin?
- Iron deficiency and anemia support
- Immune support
- Gut health
- Stomach (H. pylori) infection
- Acne
- Diarrhea prevention in infants
Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is being studied for immune support, iron levels, gut health, and infections, but the evidence is still limited and mixed for most uses. It is generally well tolerated, but talk with a pharmacist or doctor before starting it.
Protein from milk (colostrum), or made with recombinant technology · Capsules, tablets, powders; also added to some infant formulas and functional foods
An interaction check asks whether these two react with each other — it does not ask whether Lactoferrin is a good idea for someone in your situation. Here is what our Lactoferrin record says about it on its own.
Lactoferrin: dosing
There is no official standardized dose of lactoferrin, and the right amount can depend on the product, the form, and the reason for use. Doses used in research have varied widely.The best approach is to follow the directions on the product label and not exceed the recommended amount.
From our Lactoferrin monograph — the full record covers uses, side effects and every documented interaction.
About Digoxin
What Is Digoxin Used For?
Brand names: Lanoxicaps, Lanoxin, Digitek
Digoxin treats mild to moderate heart failure in adults. It improves heart failure symptoms and exercise capacity, and it reduces heart failure-related hospitalizations and emergency care. It does not change survival.
It also helps control the resting heart rate in adults with chronic atrial fibrillation (an irregular heartbeat). In children with heart failure, the tablet, oral solution and most injection products are used to increase the heart’s pumping strength (myocardial contractility). Some older injection labels list only the adult uses. Digoxin Oral Solution should not be used for multifocal atrial tachycardia.
Other Drugs & Lactoferrin
Browse every other medication we’ve checked against Lactoferrin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Lactoferrin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Sertraline ›
- Rosuvastatin ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Levothyroxine, Liothyronine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Amlodipine Besylate ›
- Docusate ›
- Metformin ›
- Prednisone ›
- Methamphetamine ›
- Amitriptyline ›
- Tadalafil ›
- Lisdexamfetamine ›
- Semaglutide ›
- Amphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Propranolol ›
- Sumatriptan ›
- Lisinopril ›
- Amoxicillin ›
- Methotrexate ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Doxycycline ›
- Acetaminophen, Aspirin, Caffeine ›
- Pregabalin ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Naproxen ›
- Bendamustine ›
- Quetiapine ›
- Clonazepam ›
- Acyclovir ›
- Buspirone ›
- Duloxetine ›
- Omeprazole ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lactoferrin list.
Lactoferrin References
The 6 references that drive our Lactoferrin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Food and Drug Administration, CFSAN/Office of Food Additive Safety. Agency Response Letter GRAS Notice No. GRN 000130. 2003. Available at: http://www.cfsan.fda.gov/~rdb/opa-g130.html (Accessed 29 June 2005).
- Okada S, Tanaka K, Sato T, et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res 2002;93:1063-9. PubMed
- Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017;219:45-52. PubMed
- Tarnow-Mordi WO, Abdel-Latif ME, Martin A, et al. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. Lancet Child Adolesc Health. 2020 Jun PubMed
- ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019 Feb 2;393(10170):423-433. doi: 10.1016/S0140-6736(18)32221-9.
- Lepanto MS, Rosa L, Cutone A, Conte MP, Paesano R, Valenti P. Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: An interventional study. Front Immunol. 2018 Sep 21;9:2123. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Digoxin Is Linked to Lower Levels of One Nutrient
Natural Medicines records Digoxin as a medicine that can lower these. This is not an interaction with Lactoferrin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Digoxin nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Lactoferrin and Digoxin Together: Common Questions
Is it safe to take Lactoferrin with Digoxin?
Do Lactoferrin and Digoxin have any of the same side effects?
Does Digoxin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Digoxin and Lactoferrin?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.