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Dietary supplement

Lily of the Valley & Blessed Thistle Ingredients & Drug Interactions

by Pure Herbs

Lily of the Valley & Blessed Thistle label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lily of the Valley & Blessed Thistle against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Lily of the Valley & Blessed Thistle is a dietary supplement by Pure Herbs with 2 active ingredients. Its ingredients are commonly taken for digestive upset and poor appetite, boosting bile flow, general bitter tonic.Based on those ingredients, 192 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lily of the Valley Root Extract, Blessed Thistle Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lily of the Valley & Blessed Thistle by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Lily of the Valley & Blessed Thistle by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lily of the Valley & Blessed Thistle by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,876 mg) without saying how much of each component you get.

This liquid contains 2 active ingredients: blessed thistle aerial parts extract and lily-of-the-valley root extract, blended together. The product has no inactive ingredients listed.

Blessed thistle is traditionally used to support digestion, though the evidence for that is not established in our data. Lily-of-the-valley contains cardiac glycosides—naturally occurring compounds that affect the heart—and has been used in herbal medicine, but again, reliable evidence for its effectiveness is not in the data we hold.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: heart health and brain function memory concentration.
  • We looked for evidence on: Arrhythmia, Heart failure, cognitive decline, cardiovascular health.
  • The closest evidence on file: Lily-of-the-valley is rated "Insufficient Reliable Evidence To Rate" for Arrhythmia (Natural Medicines).
  • Also on file: Lily-of-the-valley is rated "Insufficient Reliable Evidence To Rate" for Heart failure.

The data we have does not establish reliable evidence for either ingredient. Blessed thistle is listed as having insufficient reliable evidence to rate for indigestion (dyspepsia).

Lily-of-the-valley is listed as having insufficient reliable evidence to rate for arrhythmia or heart failure. If you're considering this product for a specific health concern, talk with your doctor about whether the evidence supports its use.

The evidence, ingredient by ingredient Blessed Thistle Lily-of-the-valley

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This product carries serious safety concerns. Lily-of-the-valley is described in the safety data as poisonous and unsafe for oral use without professional medical supervision; it can cause life-threatening heart problems, including abnormal heart rhythms, even in small amounts like 2 sprigs.

It should not be used during pregnancy or while breastfeeding. Blessed thistle is generally well tolerated in small amounts, but human safety data are limited; large doses (more than 5 grams per cup of tea) can cause stomach irritation and vomiting.

Blessed thistle is traditionally thought to affect the uterus and should be avoided during pregnancy. It has been used to support milk supply, but safety has not been well studied in breastfeeding, so you'd need to check with your doctor first.

Both ingredients can cause allergic reactions in people sensitive to the ragweed and daisy family of plants.

Side effects, ingredient by ingredient Blessed Thistle Lily-of-the-valley

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Blessed Thistle, Lily-of-the-valley.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 192 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any of these: digoxin or other heart medications, corticosteroids (especially long-term), quinine, water pills (diuretics), lithium, stimulant laxatives, or antibiotics such as macrolides (azithromycin, clarithromycin, erythromycin) or tetracyclines (doxycycline, minocycline). Additionally, check if you use H2-blockers (like famotidine), antacids, or PPIs for acid reflux.

The product's interactions span 192 medications total, so run your exact prescriptions through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product contains lily-of-the-valley, which carries Major-severity interactions with heart medications and serious safety risks. If you take digoxin, corticosteroids long-term, quinine, diuretics, lithium, stimulant laxatives, or antibiotics like macrolides or tetracyclines, do not use this product without talking to your doctor or pharmacist first.

Because of the cardiac glycoside content and toxicity risks, your own healthcare provider needs to weigh whether this product is appropriate for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lily of the Valley & Blessed Thistle, straight from the product label.

Brand Pure Herbs
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 281361
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lily of the Valley & Blessed Thistle by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
60
IngredientAmount% DV
Proprietary Blend1876 mg--
Blessed Thistle Aerial Parts Extract0 NP--
Lily of the Valley Root Extract0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial for maintaining a healthy heart and blood vessels. Promotes and enhances brain function. Strengthens memory recall, concentration and overall cognitive ability.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lily of the Valley & Blessed Thistle by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lily of the Valley & Blessed Thistle label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lily of the Valley & Blessed Thistle by Pure Herbs

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1876 mg per serving

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lily of the Valley & Blessed Thistle by Pure Herbs Drug Interactions

Want to check YOUR meds against Lily of the Valley & Blessed Thistle?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
192Drugs
26 Major 131 Moderate 35 Minor

Ingredients driving the most interactions

Lily of the Valley Root Extract 157
Blessed Thistle Aerial Parts Extract 36

Individual Drug Interactions

The ingredients in Lily of the Valley & Blessed Thistle interact with 192 drugs. Click any drug to see the details.

2 of the 2 ingredients in Lily of the Valley & Blessed Thistle interact with drugs. Each result below shows which ingredient is responsible. Lily of the Valley Root Extract Blessed Thistle Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lily of the Valley & Blessed Thistle with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lily of the Valley Root Extract8 drug types · 157 drugs

Corticosteroids

Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Concomitant, long-term corticosteroid use can increase the risk of cardiac glycoside toxicity due to potassium depletion and electrolyte imbalance.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Using lily-of-the-valley with digoxin can cause cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Use of the cardiac glycoside digoxin and lily-of-the-valley concomitantly increases the risk of cardiac glycoside toxicity.

Likelihood Likely Evidence D
Quinine

Theoretically, using lily-of-the-valley with quinine can increase the risk of cardiac glycoside toxicity.
Quinine may reduce the clearance of oral digoxin. Theoretically, concomitant use of quinine with lily-of-the-valley might reduce the clearance of cardiac glycosides found in lily-of-the-valley and increase the risk of toxicity.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, using lily-of-the-valley with diuretics can increase the risk of cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. Concomitant use of potassium depleting diuretics and lily-of-the-valley can increase the risk of cardiac glycoside toxicity due to potassium depletion and electrolyte imbalance.

Likelihood Possible Evidence D
Lithium

Theoretically, lily-of-the-valley can increase levels of lithium and increase toxicity.
Lily-of-the-valley is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lily-of-the-valley might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Macrolide Antibiotics

Theoretically, using lily-of-the-valley with macrolide antibiotics can increase the risk of cardiac glycoside toxicity.
Macrolide antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of macrolide antibiotics might increase the absorption of the cardiac glycosides found in lily-of-the-valley.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, using lily-of-the-valley with stimulant laxatives can increase the risk of cardiac glycoside toxicity.
Lily-of-the-valley contains cardiac glycosides. The overuse of stimulant laxatives can increase the risk of cardiac glycoside toxicity with lily-of-the-valley due to potassium depletion.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, using lily-of-the-valley with tetracycline antibiotics might increase the risk of cardiac glycoside toxicity.
Tetracycline antibiotics appear to increase the gastrointestinal absorption of oral digoxin, a cardiac glycoside. Theoretically, concomitant use of tetracycline antibiotics might increase the absorption of the cardiac glycosides found in lily-of-the-valley.

Likelihood Possible Evidence D
Lily of the Valley Root Extract full monograph & interactions

Blessed Thistle Aerial Parts Extract3 drug types · 36 drugs

Antacids

Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Blessed Thistle Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lily of the Valley & Blessed Thistle, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Lily of the Valley & Blessed Thistle by Pure Herbs: Common Questions

Does Lily of the Valley & Blessed Thistle by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Lily of the Valley & Blessed Thistle has a known interaction with 192 medications, including 26 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lily of the Valley & Blessed Thistle contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I'm pregnant or breastfeeding?
No. Lily-of-the-valley is rated as likely unsafe during both pregnancy and breastfeeding. Blessed thistle is also thought to be unsafe in pregnancy because it's traditionally believed to affect the uterus, and while it's been used to support milk supply, its safety in breastfeeding hasn't been well studied. Talk with your doctor or pharmacist for personalized advice if you're considering using this product while pregnant or nursing.
Is blessed thistle safe to take in large amounts?
No. While blessed thistle is generally well tolerated in small amounts, the data show that doses larger than 5 grams per cup of tea can cause stomach irritation and vomiting. Human safety data for blessed thistle are also limited overall, so stick to small doses and talk with your pharmacist if you're unsure about the right amount.
Does this product work for indigestion or heart problems?
The data we have don't establish reliable evidence that either ingredient works for these purposes. Blessed thistle and lily-of-the-valley are both listed as having insufficient reliable evidence to rate. If you're using this for a specific health concern, talk with your doctor about options with stronger evidence behind them.
What's in lily-of-the-valley that makes it risky with medications?
Lily-of-the-valley contains cardiac glycosides—compounds that affect your heart. When combined with certain medications like digoxin, water pills, or antibiotics, these compounds can build up to dangerous levels in your body and cause heart rhythm problems or other toxicity. That's why it's so important to check with your doctor before using this product if you take any heart or blood-pressure medication.
Can I get an allergic reaction from this product?
Yes, if you're sensitive to the ragweed and daisy plant family (which includes chrysanthemums, marigolds, and daisies). Blessed thistle can cause dermatitis or other allergic reactions when applied to the skin, and both ingredients may trigger sensitivity in people allergic to that plant family. If you have known allergies to ragweed or related plants, avoid this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lily of the Valley & Blessed Thistle is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lily of the Valley & Blessed Thistle label
Go deeper

The Full Monographs Behind Lily of the Valley & Blessed Thistle’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blessed Thistle

Interacts with 36 drugs

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...

Read the full Blessed Thistle monograph → Herb & supplement monograph

Lily-of-the-valley

Interacts with 157 drugs

Lily-of-the-valley is a poisonous plant that contains powerful heart-affecting compounds called cardiac glycosides, similar to the drug digoxin. While it was used historically for heart cond...

Read the full Lily-of-the-valley monograph →
Sources

Sources & How We Checked

Lily of the Valley & Blessed Thistle's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blessed Thistle 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Blessed Thistle monograph →

Lily-of-the-valley 7 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  7. Alexandre J, Foucault A, Coutance G, et al. Digitalis intoxication induced by an acute accidental poisoning by lily of the valley. Circulation 2012 Feb 28;125(8):1053-5. PubMed

See these in context on the Lily-of-the-valley monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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