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Hydrocortisone

Hydrocortisone is a corticosteroid used to replace missing cortisol in adrenal insufficiency and to calm inflammation, allergic reactions, skin conditions and ulcerative colitis, depending on the product.

Brand names Alkindi SprinkleCortefCortrilCortenemaScalpicin Itch Relief +11 more
Drug class Corticosteroid
Rx/OTC Forms 9
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 493 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

How we combine label and product data →
Other forms & routes:
Injection Rectal Topical
Hydrocortisone at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Hydrocortisone is the same steroid hormone as your body’s cortisol, the first choice to replace it when the adrenal glands fall short, and it calms inflammation by toning down the immune response, from ulcerative colitis to severe allergies and itchy skin depending on the product; on the market since about 1951, it is available generically. Replacement doses are usually well tolerated, but higher or longer courses bring the familiar steroid effects of bigger appetite, weight gain, fluid retention and mood changes. Watch above all for adrenal crisis, a potentially fatal cortisol shortage, so never stop oral hydrocortisone suddenly and get help fast if vomiting keeps you from taking it.

Clinical pearls

  • Tell every surgeon, dentist and emergency team you take hydrocortisone, since surgery or severe illness can trigger adrenal crisis.
  • Skip grapefruit juice, and flag drugs like clarithromycin, itraconazole, carbamazepine or rifampicin, which push hydrocortisone levels up or down.
  • With diabetes, check your blood sugar more often, because hydrocortisone can raise it and diabetes medicines may need adjusting.
  • Report blurred vision or new infections promptly, since steroids can cause cataracts or glaucoma and can hide signs of infection.
How we write & review this content — our editorial policy →
How you get itPrescription and over the counter
Comes asTopical cream, ointment or gel, Tablet, Rectal suppository +6
Earliest FDA record1951
Companies listing it with the FDA359
FDA label last updatedJun 5, 2025
FDA’s strongest warning (boxed)None on the label

Patient information guide — a plain-language walkthrough of Hydrocortisone, written from its FDA label.

What Hydrocortisone is used for

▾

Hydrocortisone is used for a wide range of conditions, depending on the product.

  • Cortef tablets: adrenal insufficiency, congenital adrenal hyperplasia, thyroiditis, high calcium from cancer, rheumatic disorders and collagen diseases such as lupus.
  • Solu-Cortef and hydrocortisone sodium succinate injections: severe allergic states, skin diseases (such as pemphigus), and adrenal insufficiency when oral therapy is not feasible.
  • Alkindi: adrenal insufficiency replacement in children.
  • Khindivi: replacement therapy in children 5 years and older with adrenocortical insufficiency. It is not approved for stress dosing.
  • Cortenema and Hydrocortisone Rectal Suspension: add-on therapy for ulcerative colitis.
  • Cortifoam: add-on therapy for ulcerative proctitis.
  • Hydrocortisone butyrate cream, ointment and solution: inflamed, itchy skin conditions, atopic dermatitis and seborrheic dermatitis (solution).
  • Hydrocortisone butyrate and Evesse lotions: mild to moderate atopic dermatitis in patients 3 months and older.
  • Hydrocortisone valerate cream and ointment: inflamed, itchy skin conditions in adults.

How Hydrocortisone works

▾

Hydrocortisone is a natural steroid hormone (glucocorticoid). It replaces cortisol when the body doesn't make enough. It also affects metabolism and changes how the immune system responds, which reduces inflammation.

For topical products used in atopic dermatitis, the exact mechanism is not known.

Hydrocortisone dosage

▾

How hydrocortisone is taken depends entirely on the product. Always follow your prescriber and the label.

  • Alkindi and Khindivi are generally taken three times daily.
  • Solu-Cortef is given by IV or intramuscular injection by a healthcare professional.
  • Cortenema is usually used nightly for about 21 days.
  • Cortifoam is given rectally with an applicator.
  • Hydrocortisone butyrate cream is applied thinly to affected skin, usually two or three times a day.

Dosing details from the FDA-approved label

From the Hydrocortisone prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Initial dose, adults (Solu-Cortef Sterile Powder, intravenous or intramuscular)
    • 100 mg to 500 mg, depending on the specific disease entity being treated
    • May be repeated at intervals of 2, 4, or 6 hours as indicated by the patient's response and clinical condition
    • Given intravenously over 30 seconds (e.g., 100 mg) to 10 minutes (e.g., 500 mg or more); in overwhelming, acute, life-threatening situations, dosages exceeding the usual dosages may be justified
  • Pediatric patients
    • 0.56 mg/kg/day to 8 mg/kg/day in three or four divided doses (20 mg/m2 bsa/day to 240 mg/m2 bsa/day)
    • Range of initial doses; varies depending on the specific disease entity being treated
  • Maintenance after favorable response
    • Decrease the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage that maintains an adequate clinical response is reached
    • High dose therapy usually not continued beyond 48 hours to 72 hours; withdraw gradually rather than abruptly after long-term therapy
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION The usual dose is one applicatorful once or twice daily for two or three weeks, and every second day thereafter, administered rectally. Directions for use, below and on the carton, describe how to use the aerosol container and applicator. Satisfactory response usually occurs within five to seven days marked by a decrease in symptoms. Symptomatic improvement in ulcerative proctitis should not be used as the sole criterion for evaluating efficacy. Sigmoidoscopy is also recommended to judge dosage adjustment, duration of therapy, and rate of improvement. It Should Be Emphasized that Dosage Requirements are Variable and Must Be Individualized on the Basis of the Disease Under Treatment and the Response of the Patient. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. Situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment. In this latter situation it may be necessary to increase the dosage of the corticosteroid for a period of time consistent with the patient's condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly. Directions For Use (1) Shake foam container vigorously for 5-10 seconds before each use. Do not remove container cap during use of the product. (2) Hold container upright on a level surface and gently place the tip of the applicator onto the nose of the container cap. CONTAINER MUST BE HELD UPRIGHT TO OBTAIN PROPER FLOW OF MEDICATION. (3) Pull plunger past the fill line on the applicator barrel. (4) To fill applicator barrel, press down firmly on cap flanges, hold for 1 – 2 seconds and release. Pause 5 – 10 seconds to allow foam to expand in applicator barrel. Repeat until foam reaches fill line. Remove applicator from container cap. Allow some foam to remain on the applicator tip. A burst of air may come out of container with first pump.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Hydrocortisone side effects

▾

Common side effects

  • Fluid retention
  • Changes in blood sugar (glucose tolerance)
  • Higher blood pressure
  • Mood and behavior changes
  • Increased appetite
  • Weight gain

When to get medical help

  • Get medical help right away for signs of adrenal crisis, such as severe fatigue, nausea, vomiting, low blood pressure or low blood sugar, especially after stopping hydrocortisone suddenly or during an infection or surgery.
  • Call your doctor about signs of infection, since steroids can lower your resistance and hide signs of infection.
  • Call your doctor about mood changes, severe depression, hallucinations, or unusual excitement.
  • Report blurred vision or other vision changes, which may signal cataracts or glaucoma.
  • Seek help for severe stomach pain, which can be a sign of a perforation that steroids may mask.
  • Seek emergency help for allergic reactions such as swelling or trouble breathing.
  • Report signs of Cushing's syndrome, such as a round red face, easy bruising, muscle weakness, or weight gain.
  • Children on topical steroids may be at risk of slowed growth, so report any growth concerns.

Common side effects of corticosteroids include:

  • Fluid retention
  • Changes in blood sugar
  • Higher blood pressure
  • Mood and behavior changes
  • Increased appetite
  • Weight gain

Call your doctor about signs of infection, severe mood changes, vision problems, severe stomach pain, or signs of adrenal crisis.

Hydrocortisone warnings and precautions

▾
  • Adrenal crisis: too little hydrocortisone, stopping suddenly, or stress such as infection or surgery can cause a dangerous crisis.
  • Infection risk: higher doses can weaken the immune system and mask signs of infection.
  • Long-term use: may cause Cushing's syndrome, bone thinning, eye problems and slowed growth in children.
  • Mood changes: euphoria, mania, psychosis or depression can occur.
  • Stomach problems: higher risk of perforation in certain gut conditions, and more risk with NSAIDs.
  • Injection: not for epidural or intrathecal use, and not for traumatic brain injury.

Hydrocortisone interactions

▾

Some medicines and foods can change how hydrocortisone works.

  • CYP3A4 inhibitors and grapefruit juice: can raise hydrocortisone levels.
  • CYP3A4 inducers: can lower levels and raise the risk of adrenal crisis.
  • Oral estrogens: may reduce how well Alkindi works.
  • Antidiabetic medicines: steroids can raise blood sugar.
  • Warfarin: response may change, so clotting tests are needed.
  • Cyclosporine: activity of both may increase, and convulsions have been reported.
  • NSAIDs and aspirin: raise the risk of stomach side effects.

Interactions listed in the FDA-approved label

From the Hydrocortisone prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • CYP3A4 inhibitors (anti-fungals: itraconazole, posaconazole, voriconazole; antibiotics: erythromycin and clarithromycin; antiretrovirals: ritonavir; grapefruit juice): Hydrocortisone is metabolized by CYP3A4, and inhibitors may increase serum concentrations of ALKINDI SPRINKLE and increase the risk of adverse reactions associated with excessive doses. Concomitant use may require a decrease in the ALKINDI SPRINKLE dose.
  • CYP3A4 inducers (anticonvulsants: phenytoin, carbamazepine, oxcarbazepine; antibiotics: rifampicin, rifabutin; barbiturates: phenobarbital, primidone; antiretrovirals: efavirenz, nevirapine): Inducers may decrease serum concentrations of ALKINDI SPRINKLE and increase the risk of adverse reactions, including adrenal crisis. Concomitant use may require an increase in the ALKINDI SPRINKLE dose.
  • Estrogen and estrogen-containing products: Oral estrogen and estrogen-containing oral contraceptives may increase serum cortisol-binding globulin (CBG) concentration, which may reduce the efficacy of ALKINDI SPRINKLE by binding and delaying or preventing absorption. Concomitant use may require an increase in the ALKINDI SPRINKLE dose.
  • Antidiabetic agents: Corticosteroids in supraphysiologic doses may increase blood glucose concentrations. Use of ALKINDI SPRINKLE in supraphysiologic doses may require a dose adjustment of antidiabetic agents.
  • Anticoagulant agents (warfarin): Concomitant use of warfarin and corticosteroids usually results in inhibition of response to warfarin, although there have been some conflicting reports. Monitor coagulation indices to maintain the desired anticoagulant effect.
  • Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when used concurrently; convulsions have been reported. Monitor patients receiving ALKINDI SPRINKLE and concomitant cyclosporine.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin/salicylates: Concomitant use increases the risk of gastrointestinal adverse reactions; salicylate clearance may be increased, which could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when the corticosteroid is withdrawn. Monitor patients receiving ALKINDI SPRINKLE and concomitant NSAIDs; aspirin should be used cautiously with corticosteroids in hypoprothrombinemia.
Read the label’s full interactions text

Drug Interactions Aminoglutethimide: Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression. Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents (i.e., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure. Antibiotics: Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance. Anticholinesterases: Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy. Anticoagulants, oral: Coadministration of corticosteroids and warfarin result in inhibition of response to warfarin. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect. Antidiabetics: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. Antitubercular drugs: Serum concentrations of isoniazid may be decreased. Cholestyramine: Cholestyramine may increase the clearance of corticosteroids. Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. Convulsions have been reported with this concurrent use. Digitalis glycosides: Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia. Estrogens, including oral contraceptives: Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿205 supplements and herbs with documented Hydrocortisone interactions, ranked by severity Check Hydrocortisone against a supplement or herb →

Before taking Hydrocortisone

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  • Do not use the injection with systemic fungal infections or known allergy to it.
  • Intramuscular corticosteroids are not for idiopathic thrombocytopenic purpura.
  • Tell your doctor about infections such as tuberculosis, hepatitis B or threadworm.
  • Tell your doctor if you haven't had chickenpox or measles.
  • Tell your doctor about ulcers, diverticulitis, a recent heart attack or eye herpes.
  • Khindivi is not approved under age 5.
  • Ask your doctor about breastfeeding. Steroids taken by mouth or injection appear in breast milk.
  • Children are more at risk from topical steroid absorption.

Hydrocortisone overdose

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Acute overdose is treated with supportive and symptomatic care. For chronic overdose in someone who needs continuous steroid therapy, the dose may be reduced only temporarily, or alternate-day treatment may be used.

What Hydrocortisone does in the body

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In children treated with large amounts of hydrocortisone butyrate cream or lotion three times daily, some showed lab evidence of reduced adrenal function (HPA-axis suppression). Most recovered within about a month after stopping, and none showed symptoms.

How your body processes Hydrocortisone

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Alkindi taken by mouth is about 87% absorbed compared with an IV dose, and peaks in under an hour. Over 90% of hydrocortisone in the blood is bound to proteins. It is broken down in the liver and body tissues and leaves mostly through urine. Its half-life is about 1.5 hours. Topical steroids can be absorbed through skin, especially when the skin is inflamed or covered with dressings.

How to store Hydrocortisone

▾

Hydrocortisone Butyrate Ointment, 0. Store at 20° to 25°C (68° to 77°F) .

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

205

Supplements & herbs that interact with Hydrocortisone

205 supplements and herbal products have documented interactions with Hydrocortisone in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 4
  • Moderate · 164
  • Minor · 37
ACTIVATED CHARCOAL Major GRAPEFRUIT Major LILY-OF-THE-VALLEY Major ST. JOHN'S WORT Major ACACIA RIGIDULA Moderate ACTIVE HEXOSE CORRELATED COMPOUND (AHCC) Moderate ADRAFINIL Moderate AFRICAN WILD POTATO Moderate +197 more
Every supplement checked against Hydrocortisone — ranked by severity The full interaction hub: 4 major · 164 moderate · 37 minor · every one linked to its full report. Check Hydrocortisone against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

8

Nutrient depletion considerations

Hydrocortisone has been associated with lower levels of 8 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 1
  • Moderate · 5
  • Unrated · 2
ZINC Insignificant Depletion CALCIUM Moderate Depletion CHROMIUM Moderate Depletion MAGNESIUM Moderate Depletion POTASSIUM Moderate Depletion VITAMIN D Moderate Depletion SELENIUM Insufficient Evidence STRONTIUM Insufficient Evidence
See the full Hydrocortisone nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Hydrocortisone: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Hydrocortisone — the kind of thing our pharmacy team would talk through with you at the counter.

What is hydrocortisone used for?

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It depends on the product. Tablets and oral granules are used for adrenal insufficiency, among other conditions. Injections are used for severe allergic states and skin diseases. Rectal products treat ulcerative colitis, and creams and lotions treat inflamed, itchy skin and atopic dermatitis.

Can I stop taking it if I feel better?

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Don't stop it suddenly if you take it for adrenal insufficiency. Stopping abruptly can cause adrenal crisis, which can be fatal. Talk to your prescriber before making any changes.

What side effects should I expect?

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Common ones are fluid retention, higher blood pressure, changes in blood sugar, mood changes, bigger appetite and weight gain. Call your doctor for signs of infection, vision changes, severe mood changes or severe stomach pain.

Are there medicines or foods I should avoid?

▾
Grapefruit juice and some antifungals and antibiotics can raise hydrocortisone levels. Some seizure medicines and rifampicin can lower them. Tell me about any diabetes medicines, warfarin, NSAIDs, aspirin, cyclosporine or estrogen products you use.

What if I get sick or have surgery while taking it?

▾
Stress like infection or surgery can trigger adrenal crisis if you take it for adrenal insufficiency. You may need a higher dose or a different product. If you're vomiting or can't keep your medicine down, get medical help right away, as you may need an injection.

Is Hydrocortisone available over the counter?

▾
Both. Some Hydrocortisone products are sold over the counter and others need a prescription. According to their FDA listings, the topical cream, ointment or gel, topical solution and inhaler forms are sold both ways, at different strengths or package sizes, the topical spray, rectal topical and skin patch forms are sold over the counter and the tablet, rectal suppository, injection, oral powder, enema and oral solution forms need a prescription. The package says which kind you have. Your pharmacist can tell you which product is right for you.

When was Hydrocortisone first available?

▾
The earliest FDA record we hold for Hydrocortisone is from 1951: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Hydrocortisone was first used.

Who makes Hydrocortisone?

▾
359 companies list Hydrocortisone products in the FDA's NDC Directory, including Bryant Ranch Prepack, Chattem, Inc., A-S Medication Solutions. That count includes repackagers and distributors as well as manufacturers, so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Hydrocortisone on HelloPharmacist

📊Hydrocortisone supplement interactions205 checked — ranked by severity 🌿Drug & Supplement CheckerHydrocortisone vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Hydrocortisone NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Hydrocortisone Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Hydrocortisone forms and strengths (how it comes)

Hydrocortisone is available in 9 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Topical cream, ointment or gel

On the skin
Brands Aquanil HC
How this form is used
What it may be used for
  • Hydrocortisone Butyrate cream is used for itchy, inflamed skin conditions in adults and for mild to moderate atopic dermatitis in children 3 months and older.
  • Hydrocortisone Valerate cream and ointment are medium potency steroids used for inflamed, itchy skin conditions in adults.
  • Evesse lotion is used for mild to moderate atopic dermatitis in patients 3 months and older.
Important instructions
  • Hydrocortisone Butyrate cream is applied as a thin layer and rubbed in gently, and is not for oral, eye or vaginal use.
  • Hydrocortisone Butyrate cream should be stopped when control is achieved.
Available strengths 27 strengths
0.025 mg/2.5 mL 0.45 mg/45 mL 1 mg/100 g 1 mg/100 mg 1 mg/g 1 mg/mL
Show 21 more strengths Show fewer strengths
2 mg/g 5 mg/g 0.01 g/g 10 mg/g 10 mg/mL 10.2 mg/g 10.2 mg/mL 0.0102 g/g 20 mg/g 20 mg/mL 25 mg/g 25 mg/mL 30 mg/30 g 0.1 g/g 0.5 g/100 g 1 g/100 g 1 g/g 1.02 g/100 g 1.12 g/100 g 2 g/100 g 100 g
998 FDA-listed product records ⓘ

Tablet

By mouth
Brands Cortef
How this form is used
What it may be used for
  • Cortef tablets are used for endocrine disorders such as adrenocortical insufficiency and congenital adrenal hyperplasia.
  • Cortef tablets are also used as short-term add-on therapy for rheumatic disorders such as rheumatoid arthritis and gout flares.
  • Cortef tablets are used for collagen diseases such as systemic lupus erythematosus.
Available strengths 3 strengths
5 mg 10 mg 20 mg
106 FDA-listed product records ⓘ

Rectal suppository

Rectal
Brands Anucort-hc Anusol HC Proctocort
Available strengths 2 strengths
25 mg 30 mg
66 FDA-listed product records ⓘ

Injection

Into a muscle · Into a vein
Brands Solu-Cortef
How this form is used
What it may be used for
  • Solu-Cortef is used when oral therapy is not feasible, for severe allergic states, skin diseases and adrenal insufficiency.
  • Hydrocortisone sodium succinate is used under the same circumstances.
Important instructions
  • Solu-Cortef can be given by IV injection, IV infusion or intramuscular injection, and should not be mixed with other solutions.
  • Hydrocortisone sodium succinate is preferably given by IV injection for initial emergency use.
Available strengths 4 strengths
100 mg/2 mL 250 mg/2 mL 500 mg/4 mL 1000 mg/8 mL
29 FDA-listed product records ⓘ

Topical solution

On the skin
Brands Hydrocortisone Butyrate
How this form is used
What it may be used for
  • Hydrocortisone Butyrate topical solution 0.1% is used for seborrheic dermatitis.
Available strengths 4 strengths
1 mg/mL 10 mg/mL 25 mg/mL 1 g/100 mL
21 FDA-listed product records ⓘ

Topical spray

On the skin
Available strengths 3 strengths
10 mg/g 10 mg/mL 1 g/100 g
13 FDA-listed product records ⓘ

Inhaler

On the skin
Brands Cortifoam
How this form is used
What it may be used for
  • Cortifoam is used as add-on therapy for ulcerative proctitis of the distal rectum in patients who cannot retain corticosteroid enemas.
Important instructions
  • Cortifoam is given rectally with an applicator, usually once or twice daily for two or three weeks, then every second day.
  • Cortifoam response usually occurs within five to seven days.
Available strengths 2 strengths
10 mg/g 1.13 g/113 g
8 FDA-listed product records ⓘ

Oral powder

By mouth
Brands Alkindi
How this form is used
What it may be used for
  • Alkindi is used as replacement therapy in children with adrenocortical insufficiency.
Important instructions
  • Alkindi granules come in capsules. Do not swallow the capsule.
  • Alkindi is generally divided into three doses a day.
Available strengths 4 strengths
0.5 mg 1 mg 2 mg 5 mg
8 FDA-listed product records ⓘ

Enema

Rectal
Brands Cortenema
How this form is used
What it may be used for
  • Cortenema is used as add-on therapy for ulcerative colitis, especially distal forms such as ulcerative proctitis.
  • Hydrocortisone Rectal Suspension (Retention) is used as add-on therapy for ulcerative colitis, including left-sided disease.
Important instructions
  • Cortenema is usually used nightly for 21 days or until remission.
  • Cortenema is stopped gradually after 21 days by reducing to every other night for 2 or 3 weeks.
  • Hydrocortisone Rectal Suspension (Retention) symptoms usually improve within 3 to 5 days.
Available strengths 1 strength
100 mg/60 mL
6 FDA-listed product records ⓘ

Hydrocortisone on the U.S. market: products, makers and brands

How Hydrocortisone appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

359 companies list 1,393 Hydrocortisone product records with the FDA, mostly as topical cream, ointment or gel, tablet, rectal suppository; the earliest marketing or approval year on record is 1951. Brand names on the directory include Alkindi Sprinkle, Cortef, Cortril and 13 more; the rest are generics.

9
Dose forms ⓘ
359
Labelers (makers, repackagers, distributors)
40
Brand names
1,393
FDA-listed product records ⓘ
1951
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (65) · Kit (4) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack12%
Chattem, Inc.8%
A-S Medication Solutions5%
Pharmacia & Upjohn Company LLC5%
Trifecta Pharmaceuticals Usa Llc4%
NuCare Pharmaceuticals,Inc.4%
Other makers61%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Hydrocortisone is used (Medicaid data)

A general measure of how commonly Hydrocortisone is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Hydrocortisone is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

3,162,599
Medicaid prescriptions filled (Q1–Q4 2025)
$87.3M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Hydrocortisone prescribed? Of the 1,601 medications we measure, Hydrocortisone ranks #68 by Medicaid prescriptions — more than 96% of them.

Where Hydrocortisone ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #68 of 1,601
#63 Budesonide / Formotero... 3,326,951 Rx #64 Meloxicam 3,321,801 Rx #65 Folic Acid 3,298,551 Rx #66 Metronidazole 3,247,421 Rx #67 Hydrochlorothiazide 3,216,975 Rx #68 Hydrocortisone 3,162,599 Rx #69 Divalproex 3,122,967 Rx #70 Tirzepatide injection 3,083,095 Rx #71 Tirzepatide 3,083,095 Rx #72 Levetiracetam 3,055,070 Rx #73 Oxycodone 3,037,434 Rx

Utilization by Hydrocortisone product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 25 mg/mL topical cream is the most-dispensed Hydrocortisone product — about 41% of these Medicaid prescriptions.

hydrocortisone 25 MG/ML Topical Cream Most dispensed

1,308,098 Medicaid prescriptions (Q1–Q4 2025) 41% of Hydrocortisone prescriptions shown $15.7M gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 11 of 69 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310891

hydrocortisone 0.025 MG/MG Topical Ointment

892,566 Medicaid prescriptions (Q1–Q4 2025) 28% of Hydrocortisone prescriptions shown $10.7M gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 4 of 15 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 103401

hydrocortisone 10 MG/ML Topical Cream

419,091 Medicaid prescriptions (Q1–Q4 2025) 13% of Hydrocortisone prescriptions shown $5.5M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 24 of 491 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 106258

hydrocortisone 0.01 MG/MG Topical Ointment

192,661 Medicaid prescriptions (Q1–Q4 2025) 6% of Hydrocortisone prescriptions shown $2.6M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 7 of 77 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 203105

hydrocortisone 5 MG Oral Tablet

116,759 Medicaid prescriptions (Q1–Q4 2025) 4% of Hydrocortisone prescriptions shown $2.9M gross reimbursement (before rebates) ≈ $25 per prescription (gross)

Summed across the 7 of 36 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197787

hydrocortisone 10 MG Oral Tablet

69,349 Medicaid prescriptions (Q1–Q4 2025) 2% of Hydrocortisone prescriptions shown $1.8M gross reimbursement (before rebates) ≈ $25 per prescription (gross)

Summed across the 7 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197782

hydrocortisone 25 MG/ML Topical Lotion

44,028 Medicaid prescriptions (Q1–Q4 2025) 1% of Hydrocortisone prescriptions shown $1M gross reimbursement (before rebates) ≈ $24 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197785

hydrocortisone 5 MG/ML Topical Cream

23,745 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $189,563 gross reimbursement (before rebates) ≈ $7.98 per prescription (gross)

Summed across the 2 of 19 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198707

hydrocortisone butyrate 1 MG/ML Topical Solution

21,784 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $2.4M gross reimbursement (before rebates) ≈ $111 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1370767

hydrocortisone 20 MG Oral Tablet

14,634 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $354,823 gross reimbursement (before rebates) ≈ $24 per prescription (gross)

Summed across the 5 of 20 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197783

hydrocortisone 100 MG Injection

14,215 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $896,589 gross reimbursement (before rebates) ≈ $63 per prescription (gross)

Summed across the 3 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 238755

hydrocortisone 0.02 MG/MG Topical Gel

12,314 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $27.4M gross reimbursement (before rebates) ≈ $2,224 per prescription (gross)

Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 604449

hydrocortisone 25 MG/ML Topical Solution

7,660 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $5.7M gross reimbursement (before rebates) ≈ $738 per prescription (gross)

Summed across the 2 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197786

hydrocortisone butyrate 1 MG/ML Topical Cream

5,046 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $897,126 gross reimbursement (before rebates) ≈ $178 per prescription (gross)

Summed across the 2 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1370770

hydrocortisone valerate 2 MG/ML Topical Cream

4,431 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $100,610 gross reimbursement (before rebates) ≈ $23 per prescription (gross)

Summed across the 10 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1370754

hydrocortisone valerate 0.002 MG/MG Topical Ointment

3,029 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $260,064 gross reimbursement (before rebates) ≈ $86 per prescription (gross)

Summed across the 3 of 14 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1370750

hydrocortisone butyrate 1 MG/ML Topical Lotion

2,800 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $804,932 gross reimbursement (before rebates) ≈ $287 per prescription (gross)

Summed across the 4 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1370763

hydrocortisone acetate 0.01 MG/MG Topical Ointment

2,716 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $30,418 gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 2 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1440184

hydrocortisone 1.67 MG/ML Enema

1,721 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $299,826 gross reimbursement (before rebates) ≈ $174 per prescription (gross)

Summed across the 1 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310878

hydrocortisone butyrate 0.001 MG/MG Topical Ointment

1,251 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $148,093 gross reimbursement (before rebates) ≈ $118 per prescription (gross)

Summed across the 2 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1370758

hydrocortisone acetate 25 MG Rectal Suppository

1,111 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $112,790 gross reimbursement (before rebates) ≈ $102 per prescription (gross)

Summed across the 8 of 69 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1291082

hydrocortisone 2 MG Oral Granules

864 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $3.2M gross reimbursement (before rebates) ≈ $3,725 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2399656

hydrocortisone acetate 100 MG/ML Rectal Foam

845 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $505,603 gross reimbursement (before rebates) ≈ $598 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1545172

hydrocortisone 1 MG Oral Granules

804 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $1.5M gross reimbursement (before rebates) ≈ $1,817 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2399652

hydrocortisone 0.5 MG Oral Granules

381 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $334,017 gross reimbursement (before rebates) ≈ $877 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2399644

hydrocortisone 250 MG Injection

310 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $22,929 gross reimbursement (before rebates) ≈ $74 per prescription (gross)

Summed across the 2 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1738590

hydrocortisone 5 MG Oral Granules

281 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $1.9M gross reimbursement (before rebates) ≈ $6,805 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2399659

hydrocortisone 1000 MG Injection

105 Medicaid prescriptions (Q1–Q4 2025) <1% of Hydrocortisone prescriptions shown $23,424 gross reimbursement (before rebates) ≈ $223 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1738586

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Hydrocortisone, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 116 of 953 listed Hydrocortisone NDCs with Medicaid activity.

Compare Hydrocortisone products

A representative set of FDA-listed product records for Hydrocortisone — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 1,393 products — FDA National Drug Code Directory. See every product, package size and price: browse all 1,393 Hydrocortisone NDCs →

Hydrocortisone recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Hydrocortisone recalls since July 2021. None of them is still listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Class II Apr 24, 2025 · Terminated · KENIL HEALTHCARE PRIVATE LIMITED
CGMP Deviations
  • Rapidol Maximum Strength, Hydrocortisone 1% Anti-Itch Cream, NET WT 2 oz (60g) Tube, Distributed by: Pharmadel LLC, New Castle, DE, 19720, NDC 55758-420-02, UPC 8 10096 77158 2. Lots: Lot SP26A, Exp: 09/30/2026 FDA record D-0428-2025 →
Class II Apr 13, 2022 · Terminated · Mckesson Medical-Surgical Inc. Corporate Office
cGMP deviations: Temperature abuse
  • Hydrocortisone Ointment USP, 2.5%, NET WT 28.35 g (1 oz) tube, Rx only, MFG: Sandoz Pharma, NDC 0168-0146-30 Lots: McKesson Medical-Surgical (MMS) is not able to identify the particular lot number received by a particular consignee for the recalled prescription products. Each letter includes the date it was distributed to customers and the dates that i… FDA record D-1045-2022 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Hydrocortisone RxCUI 5492 26 dose forms · 66 strengths
  1. Dose form (SCDF) Enema RxCUI 372421 In current FDA listings
    Clinical drug / strength (SCD) 1.67 MG/ML RxCUI 310878
  2. Dose form (SCDF) Injectable Solution RxCUI 370648 In current FDA listings
    Clinical drug / strength (SCD) sodium phosphate 50 MG/ML RxCUI 1037338 100 MG/ML RxCUI 250788
  3. Dose form (SCDF) Injectable Suspension RxCUI 378635 In current FDA listings
    Clinical drug / strength (SCD) 25 MG/ML RxCUI 238754
  4. Dose form (SCDF) Injection RxCUI 1738585 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 238755 250 MG RxCUI 1738590 500 MG RxCUI 1738594 1000 MG RxCUI 1738586
  5. Dose form (SCDF) Medicated Shampoo RxCUI 900410 In current FDA listings
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 1926571
  6. Dose form (SCDF) Ophthalmic Ointment RxCUI 108133 No current FDA listing
    Clinical drug / strength (SCD) acetate 0.005 MG/MG RxCUI 1542920 acetate 0.01 MG/MG RxCUI 1542921 acetate 0.025 MG/MG RxCUI 1542922
  7. Dose form (SCDF) Ophthalmic Solution RxCUI 372417 No current FDA listing
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 250804
  8. Dose form (SCDF) Oral Granules RxCUI 2399643 In current FDA listings
    Clinical drug / strength (SCD) 0.5 MG RxCUI 2399644 1 MG RxCUI 2399652 2 MG RxCUI 2399656 5 MG RxCUI 2399659
  9. Dose form (SCDF) Oral Lozenge RxCUI 372422 No current FDA listing
    Clinical drug / strength (SCD) 2.5 MG RxCUI 251452
  10. Dose form (SCDF) Oral Solution RxCUI 2716549 No current FDA listing
    Clinical drug / strength (SCD) 1 MG/ML RxCUI 2716550
  11. Dose form (SCDF) Oral Suspension RxCUI 370647 No current FDA listing
    Clinical drug / strength (SCD) 2 MG/ML RxCUI 310899
  12. Dose form (SCDF) Oral Tablet RxCUI 370649 In current FDA listings
    Clinical drug / strength (SCD) 5 MG RxCUI 197787 10 MG RxCUI 197782 20 MG RxCUI 197783
  13. Dose form (SCDF) Otic Solution RxCUI 372423 No current FDA listing
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 240749
  14. Dose form (SCDF) Rectal Cream RxCUI 377723 No current FDA listing
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 310868 25 MG/ML RxCUI 310879
  15. Dose form (SCDF) Rectal Foam RxCUI 376828 No current FDA listing
    Clinical drug / strength (SCD) acetate 100 MG/ML RxCUI 1545172
  16. Dose form (SCDF) Rectal Ointment RxCUI 372418 No current FDA listing
    Clinical drug / strength (SCD) 0.01 MG/MG RxCUI 260192
  17. Dose form (SCDF) Rectal Suppository RxCUI 370645 In current FDA listings
    Clinical drug / strength (SCD) acetate 25 MG RxCUI 1291082 acetate 30 MG RxCUI 1291085
  18. Dose form (SCDF) Topical Cream RxCUI 377712 In current FDA listings
    Clinical drug / strength (SCD) acetate 10 MG/ML RxCUI 1043690 acetate 20 MG/ML RxCUI 251224 acetate 25 MG/ML RxCUI 1809843 acetate 5 MG/ML RxCUI 1250490 butyrate 1 MG/ML RxCUI 1370770 probutate 1 MG/ML RxCUI 1370746 valerate 2 MG/ML RxCUI 1370754 1 MG/ML RxCUI 106248 5 MG/ML RxCUI 198707 10 MG/ML RxCUI 106258 20 MG/ML RxCUI 2677688 25 MG/ML RxCUI 310891
  19. Dose form (SCDF) Topical Foam RxCUI 832710 In current FDA listings
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 832711
  20. Dose form (SCDF) Topical Gel RxCUI 377961 In current FDA listings
    Clinical drug / strength (SCD) 0.01 MG/MG RxCUI 198706 0.02 MG/MG RxCUI 604449
  21. Dose form (SCDF) Topical Lotion RxCUI 377713 In current FDA listings
    Clinical drug / strength (SCD) acetate 5 MG/ML RxCUI 1489372 butyrate 1 MG/ML RxCUI 1370763 5 MG/ML RxCUI 244492 10 MG/ML RxCUI 103403 20 MG/ML RxCUI 197784 25 MG/ML RxCUI 197785
  23. Dose form (SCDF) Topical Powder RxCUI 376507 No current FDA listing
    Clinical drug / strength (SCD) 1 MG/MG RxCUI 310877
  24. Dose form (SCDF) Topical Solution RxCUI 370646 In current FDA listings
    Clinical drug / strength (SCD) butyrate 1 MG/ML RxCUI 1370767 10 MG/ML RxCUI 310869 25 MG/ML RxCUI 197786
  25. Dose form (SCDF) Topical Spray RxCUI 377305 In current FDA listings
    Clinical drug / strength (SCD) 5 MG/ML RxCUI 310858 10 MG/ML RxCUI 317564
  26. Dose form (SCDF) Vaginal Cream RxCUI 1039348 No current FDA listing
    Clinical drug / strength (SCD) acetate 10 MG/ML RxCUI 1039349 10 MG/ML RxCUI 1494032

Look up RxCUI 5492 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Hydrocortisone brand names

Hydrocortisone is sold under 16 brand names in the FDA directory — Alkindi Sprinkle, Cortef, Cortril, Cortenema and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Alkindi Sprinkle Cortef Cortril Cortenema Scalpicin Itch Relief Cortizone Vagisil Satin Aquanil HC Beta-HC Solu-Cortef Hemril Proctocort Anucort-HC Anusol HC Proctosol Kera-HC

Who makes Hydrocortisone: manufacturers and labelers

40 companies list Hydrocortisone products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Chattem, Inc., A-S Medication Solutions. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 75 Chattem, Inc. 50 A-S Medication Solutions 33 Pharmacia & Upjohn Company LLC 29 Trifecta Pharmaceuticals Usa Llc 27 NuCare Pharmaceuticals,Inc. 26 CVS Pharmacy 19 Taro Pharmaceuticals U.S.A., Inc. 17 Unifirst First Aid Corporation 17 Proficient Rx LP 15 Topco Associates LLC 15 Padagis Israel Pharmaceuticals Ltd 14 Walgreens 14 Sun Pharmaceutical Industries, Inc. 14 Crown Laboratories 14 Eton Pharmaceuticals, Inc. 13 Safeway 12 Target Corporation 12 ANI Pharmaceuticals, Inc. 12 Strategic Sourcing Services LLC 12 Rite Aid Corporation 11 Opmx Llc 10 Preferred Pharmaceuticals Inc. 10 Orazen Inc 10

…and 16 more on the FDA NDC directory.

Hydrocortisone drug class (RxNorm)

Hydrocortisone belongs to the Corticosteroid class.

Pharmacologic class Corticosteroid
Drug family (ATC) Corticosteroids, moderately potent (group II), Corticosteroids, potent (group III), Corticosteroids for local oral treatment
How it works Corticosteroid Hormone Receptor Agonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Hydrocortisone page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jun 5, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Hydrocortisone.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Hydrocortisone after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
493
NDC products indexed
1,393
Distinct labelers/manufacturers represented
359
Linked representative label ⓘ
Oceanside Pharmaceuticals
Linked label effective
Jun 5, 2025
Composite sections available
24
Linked SPL Set ID
ddf699f4-1ae0-48c3-8d2a-56aa1a2c5bc1
Linked SPL Document ID
36d82d8e-8303-bf39-e063-6394a90a2fab
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Oceanside Pharmaceuticals is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →