Drug & supplement interaction

Black Root + Digoxin

Digoxin brand names: Lanoxicaps, Lanoxin, Digitek.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Black Root has a moderate interaction with Digoxin. Theoretically, the overuse or abuse of black root can increase the risk of adverse effects of cardiac glycoside drugs.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Black Root and Digoxin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

DIGOXIN (Lanoxin)

Theoretically, the overuse or abuse of black root can increase the risk of adverse effects of cardiac glycoside drugs. Black root chemically binds with the glycosides while in the gastrointestinal (GI) tract, which may reduce their effectiveness if used concomitantly.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing about pairing Black Root with your digoxin. This herb is a strong laxative, and that matters in two ways. First, because it speeds things through your gut, your body may absorb less of your digoxin dose, so you could get less of the heart-steadying benefit you count on. On top of that, the plant compounds in Black Root may actually bind to the digoxin in your stomach and intestines, again pulling down how much gets into your system.

I'll be honest, this is a theoretical concern based on how the herb behaves, not solid human studies. But digoxin is a narrow-margin drug where small swings matter, so watch for a faster or more irregular heartbeat or returning heart-failure symptoms. Please check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Black Root Also Interacts With Other Medications

Black Root has 77 moderate known drug interactions in our database — the Digoxin one above is one of them. If you take anything else, check it against the full list below.

Moderate 77 No known interaction 2,753 (incl. Digoxin)
Taking anything else?

Check Another of Your Medications Against Black Root

Covers the 2,830 medications we’ve checked against Black Root. Pick one to open its full report.

From our Q&A

Questions About Black Root or Digoxin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Black Root or Digoxin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Digoxin

This page covers Black Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Digoxin page lists 113 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Aloe (major), Blue Flag (major), Danshen (major) and European Buckthorn (major).

By severity: 18 major · 79 moderate · 16 minor.

From our pharmacist’s overview on the Digoxin page

“Digoxin is a heart medicine with a narrow therapeutic index, meaning the gap between a helpful blood level and a harmful one is small, and few drugs give me more pause when supplements enter the picture. The most serious entries here are herbs that themselves contain digoxin-like cardiac glycosides, foxglove and lily-of-the-valley amon…”

Reviewed by 2 · Jul 18, 2026

Open the Digoxin interaction page

One more smart check

Taking Black Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 41 real supplement products containing Black Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Root. Your product may carry other ingredients that interact with Digoxin too, on top of Black Root — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Black Root and Digoxin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Root
Top half

#656 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Digoxin
Top 25%

#517 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Black Root

What is Black Root?

  • Constipation
  • Liver and gallbladder complaints
  • Digestive upset
  • Stimulating bile flow

Black Root is a traditional North American herb that was historically used as a strong laxative and to support digestion and liver function. There is very little modern scientific evidence to support these uses, and the fresh root can be toxic, so it should be used cautiously, if at all, and never during pregnancy or breastfeeding.

Read the full Black Root monograph & all interactions
Medication

About Digoxin

What Is Digoxin Used For?

Brand names: Lanoxicaps, Lanoxin, Digitek

Digoxin treats mild to moderate heart failure in adults. It improves heart failure symptoms and exercise capacity, and it reduces heart failure-related hospitalizations and emergency care. It does not change survival.

It also helps control the resting heart rate in adults with chronic atrial fibrillation (an irregular heartbeat). In children with heart failure, the tablet, oral solution and most injection products are used to increase the heart’s pumping strength (myocardial contractility). Some older injection labels list only the adult uses. Digoxin Oral Solution should not be used for multifocal atrial tachycardia.

See full Digoxin drug information
Keep checking

Other Drugs & Black Root

Browse every other medication we’ve checked against Black Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
77Moderate
0Minor
2,752No known interaction
77 Moderate 2,752 No interaction
Moderate

77 interactions

Showing 60 of 77 moderate interactions — see all 77 on the Black Root page.

No interaction 2,752 drugs checked — show the list

We also checked Black Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,752 medications checked with no known interaction — see the full Black Root list.

See the full Black Root interactions page
See every supplement checked against Digoxin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Black Root monograph › Uses, safety, and every drug interaction in one place Digoxin supplement interactions › Every supplement checked against Digoxin, ranked by severity Digoxin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Black Root and Digoxin Together: Common Questions

Can you take Black Root with Digoxin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Black Root and Digoxin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Digoxin and Black Root?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.