Drug & supplement interaction

Jimson Weed + Brentuximab Vedotin

Brentuximab Vedotin brand name: Adcetris.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Jimson Weed and Brentuximab Vedotin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Jimson Weed and Brentuximab Vedotin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Brentuximab Vedotin and Jimson Weed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jimson Weed safety at a glance

Jimson Weed overall Avoid Jimson Weed is toxic and can cause life-threatening poisoning even at small doses.
Pregnancy Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Brentuximab Vedotin and Jimson Weed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Brentuximab Vedotin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Brentuximab Vedotin is filed under a single classification — cytochrome p450 3a4 (cyp3a4) substrates. Jimson Weed has documented interactions with 1 drug class — the most serious being anticholinergic drugs (moderate) — and none of Brentuximab Vedotin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jimson Weed Does Interact With Other Medications

Jimson Weed has 195 moderate known drug interactions in our database — Brentuximab Vedotin isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Jimson Weed

Covers the 2,830 medications we’ve checked against Jimson Weed. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jimson Weed and Brentuximab Vedotin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • A low platelet count Worth acting on Additional detail

    Jimson Weed

    “Orally, jimson weed has been reported to cause thrombocytopenia in one patient.”

    Jimson Weed · Natural Medicines adverse-effect record, reported in thrombocytopenia.

    1 source cited
    1. 109502. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.

    Brentuximab Vedotin

    Listed in the ADVERSE REACTIONS section of the FDA label for Brentuximab Vedotin. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Jimson Weed

    “Orally, jimson weed can cause hepatotoxic events, including fulminant hepatitis.”

    Jimson Weed · Natural Medicines adverse-effect record, reported in hepatitis.

    1 source cited
    1. 57091. Ertekin, V., Selimoglu, M. A., and Altinkaynak, S. A combination of unusual presentations of Datura stramonium intoxication in a child: rhabdomyolysis and fulminant hepatitius. J Emerg.Med. 2005;28(2):227-228. PubMed

    Brentuximab Vedotin

    Listed in the ADVERSE REACTIONS section of the FDA label for Brentuximab Vedotin. Read the label on DailyMed ›

  • Fever reported in 14.1% of FDA reports for Brentuximab Vedotin Additional detail

    Jimson Weed

    “Orally, jimson weed can block muscarinic cholinergic neurons and cause anticholinergic side effects. Larger amounts of jimson weed intake can also lead to toxicity and anticholinergic syndrome. Central anticholinergic symptoms, which are dose-dependent, include muscle tremor and rigidity, leg cramps, hallucinations, slurred speech, psychosis, agitated delirium, seizures, coma, cardiovascular collapse, or respiratory…”

    Jimson Weed · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 636. Hassell LH, MacMillan MW. Acute anticholinergic syndrome following ingestion of Angel's trumpet tea. Hawaii Med J 1995;54:669-70.
    2. 57067. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
    3. 57075. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed
    4. 57077. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
    5. 57078. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed
    6. 57084. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed

    Brentuximab Vedotin

    Listed in the ADVERSE REACTIONS section of the FDA label for Brentuximab Vedotin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Stomach pain / Vomiting / Nausea Additional detail

    Jimson Weed

    “Orally, jimson weed can cause anticholinergic side effects such as abdominal pain, nausea and vomiting, decreased bowel sounds, and difficulty swallowing (13,18,5623,109502,113142).”

    Jimson Weed · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    5 sources cited
    1. 13. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 5623. Anon. Jimson weed poisoning- Texas, New York, and California, 1994. MMWR Morb Mortal Wkly Rep 1995;44:41-4.
    4. 109502. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
    5. 113142. Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604. PubMed

    Brentuximab Vedotin

    Listed in the ADVERSE REACTIONS section of the FDA label for Brentuximab Vedotin. Read the label on DailyMed ›

Reported for Jimson Weed but not commonly for Brentuximab Vedotin: trouble swallowing, confusion, trouble passing urine and hallucinations.

Effects for Brentuximab Vedotin come from the ADVERSE REACTIONS section of its FDA label; effects for Jimson Weed come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 10,190 voluntary FDA FAERS reports for Brentuximab Vedotin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Jimson Weed in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Brentuximab Vedotin

This page covers Jimson Weed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Brentuximab Vedotin page lists 121 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 87 moderate · 32 minor.

From our pharmacist’s overview on the Brentuximab Vedotin page

“Every entry on this page traces back to a single enzyme. Brentuximab vedotin (Adcetris), an IV treatment for Hodgkin lymphoma and certain other lymphomas, carries a chemotherapy payload the body clears through CYP3A4, and I would treat this list with real care.”

Reviewed by 2 · Jul 18, 2026

Open the Brentuximab Vedotin interaction page

One more smart check

Taking Jimson Weed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Jimson Weed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jimson Weed. Even though Jimson Weed itself has no known interaction with Brentuximab Vedotin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jimson Weed and Brentuximab Vedotin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jimson Weed
Steady interest

#998 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Brentuximab Vedotin
Top 25%

#628 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jimson Weed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Jimson Weed and Brentuximab Vedotin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jimson Weed

What is Jimson Weed?

  • Asthma and breathing problems (historical/folk use)
  • Pain relief
  • Recreational hallucinogen (highly dangerous misuse)
  • Muscle spasms
  • Skin conditions (traditional topical use)

Jimson Weed is a highly poisonous plant that contains powerful nerve-affecting compounds, and even small amounts can cause severe poisoning, hallucinations, or death. It is not a safe supplement, and there is no reliable evidence supporting its use for any health condition. Do not use Jimson Weed in any form.

Datura stramonium · Solanaceae · Leaves, seeds, flowers, and roots · Dried plant material, smoked preparations, teas, and folk extracts (none are recommended for self-use)

An interaction check asks whether these two react with each other — it does not ask whether Jimson Weed is a good idea for someone in your situation. Here is what our Jimson Weed record says about it on its own.

Jimson Weed: dosing

There is no safe or established dose of Jimson Weed. The amount of toxic alkaloids varies widely from plant to plant, season to season, and even between different parts of the same plant, so there is no way to take a predictable amount.Because of this, no responsible pharmacist or doctor recommends using it.

From our Jimson Weed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jimson Weed monograph & all interactions
Medication

About Brentuximab Vedotin Injection

What Is Brentuximab Vedotin Injection Used For?

Brand name: Adcetris

Adcetris (brentuximab vedotin) is used to treat classical Hodgkin lymphoma (cHL) in adults — including newly diagnosed advanced-stage disease, as consolidation therapy after a stem cell transplant, and in relapsed or refractory cases. It is also approved for pediatric patients aged 2 and older with previously untreated high-risk classical Hodgkin lymphoma, given in combination with chemotherapy.

Adcetris is also used for several T-cell lymphomas — including systemic anaplastic large cell lymphoma (sALCL), peripheral T-cell lymphomas (PTCL), primary cutaneous anaplastic large cell lymphoma (pcALCL), and CD30-expressing mycosis fungoides (MF). Additionally, Adcetris is used in combination with lenalidomide and a rituximab product for adults with relapsed or refractory large B-cell lymphoma (LBCL) who are not candidates for a stem cell transplant or CAR T-cell therapy.

Most-Reported Side Effects for Brentuximab Vedotin

From FAERS, the FDA’s public side-effect reporting system (10,190 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Febrile neutropenia 758 reports
Neuropathy peripheral 711 reports
Fever 682 reports
Neutropenia 586 reports
Hodgkin^s disease 459 reports
See full Brentuximab Vedotin Injection drug information
Keep checking

Other Drugs & Jimson Weed

Browse every other medication we’ve checked against Jimson Weed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
195Moderate
0Minor
2,634No known interaction
Moderate

195 interactions

Showing 60 of 195 moderate interactions — see all 195 on the Jimson Weed page.

No interaction 2,634 drugs checked — show the list
Evidence & sources

Jimson Weed References

The 43 references that drive our Jimson Weed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Hassell LH, MacMillan MW. Acute anticholinergic syndrome following ingestion of Angel's trumpet tea. Hawaii Med J 1995;54:669-70.
  6. Urich RW, Bowerman DL, Levisky JA, Pflug JL. Datura stramonium: a fatal poisoning. J Forensic Sci 1982;27:948-54.
  7. Anon. Jimson weed poisoning- Texas, New York, and California, 1994. MMWR Morb Mortal Wkly Rep 1995;44:41-4.
  8. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
  9. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed
  10. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
  11. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed
  12. Sasaki, T., Yamazaki, K., Yamori, T., and Endo, T. Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin. Br.J Cancer 10-7-2002;87(8):918-923. PubMed
  13. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed
  14. Parissis, D., Mellidis, C., Boutis, A., Apostolidis, K., Ignatiadis, M., Kiosses, V., and Milonas, I. Neurological findings in a case of coma secondary to Datura stramonium poisoning. Eur J Neurol. 2003;10(6):745-746.
  15. Boumba, V. A., Mitselou, A., and Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Vet.Hum.Toxicol. 2004;46(2):81-82.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jimson Weed and Brentuximab Vedotin Together: Common Questions

Is it safe to take Jimson Weed with Brentuximab Vedotin?
We do not list a known interaction between Jimson Weed and Brentuximab Vedotin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jimson Weed and Brentuximab Vedotin have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Jimson Weed and Brentuximab Vedotin combination checked?
Interactions in our licensed database are recorded against drug classes. Brentuximab Vedotin is filed under 1 classification, and Jimson Weed has documented interactions with 1 drug class — none of Brentuximab Vedotin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jimson Weed interact with any other medications?
Yes. Jimson Weed has 195 documented drug interactions in our database — Brentuximab Vedotin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Brentuximab Vedotin interact with any supplements?
Yes. Brentuximab Vedotin has documented interactions with 121 supplements in our database — Jimson Weed is not one of them. The Brentuximab Vedotin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Brentuximab Vedotin and Jimson Weed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.