Medication interaction hub

What Supplements Interact with Brentuximab Vedotin?

Brentuximab Vedotin brand name: Adcetris. Every interaction below applies to the brands too.

121 Interactions 2 Major 87 Moderate 32 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Brentuximab Vedotin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Brentuximab Vedotin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Every entry on this page traces back to a single enzyme. Brentuximab vedotin (Adcetris), an IV treatment for Hodgkin lymphoma and certain other lymphomas, carries a chemotherapy payload the body clears through CYP3A4, and I would treat this list with real care. Grapefruit blocks that enzyme and can let the payload build up, raising the risk of serious side effects, while St. John's wort speeds it up and can quietly weaken the treatment itself. Those two are the ones to learn first.

Most of the rest lean the same two ways, nudging drug levels up or down, though much of that evidence comes from lab research rather than patients. With a cancer treatment, both directions matter, so run any supplement past the oncology team first. Of the 121 ingredients on file, only those two rate major, with 87 moderate and 32 minor behind them.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 87 Minor 32 No known interaction 1,331

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Brentuximab Vedotin: Top Interactions at a Glance

The Brentuximab Vedotin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 121 interacting ingredients — plus 1,331 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Brentuximab Vedotin Combinations Today

The Brentuximab Vedotin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Licorice + Brentuximab Vedotini

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Vitamin E + Brentuximab Vedotini

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Danshen + Brentuximab Vedotini

Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Rhodiola + Brentuximab Vedotini

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Kava + Brentuximab Vedotini

It is unclear if kava inhibits CYP3AA; research is conflicting.

Read the full interaction Major Likelihood Likely Grapefruit + Brentuximab Vedotini

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Brentuximab Vedotin

All 1,452 ingredients in our database, ranked by severity — 121 with a Brentuximab Vedotin interaction on file and 1,331 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Brentuximab Vedotin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Licorice with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Brentuximab Vedotin answer

Can you take Vitamin E with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Brentuximab Vedotin answer

Can you take Danshen with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Brentuximab Vedotin answer

Can you take Rhodiola with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Full Rhodiola + Brentuximab Vedotin answer

Can you take Kava with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP3AA; research is conflicting.

Full Kava + Brentuximab Vedotin answer

Can you take Milk Thistle with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Brentuximab Vedotin answer

Can you take Mommy's Bliss Gripe Water with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Brentuximab Vedotin answer

Can you take Polypodium Leucotomos with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Brentuximab Vedotin answer

Can you take Pomegranate with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Brentuximab Vedotin answer

Can you take Red Clover with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Brentuximab Vedotin answer

Can you take Tangerine with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Brentuximab Vedotin answer

Can you take Grapefruit with Brentuximab Vedotin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Brentuximab Vedotin answer

Can you take St. John's Wort with Brentuximab Vedotin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Brentuximab Vedotin answer

Can you take Cannabidiol (cbd) with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Full Cannabidiol (cbd) + Brentuximab Vedotin answer

Can you take Guggul with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Brentuximab Vedotin answer

Can you take Schisandra with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Brentuximab Vedotin answer

Can you take Tree Turmeric with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Brentuximab Vedotin answer

Can you take Acacia Rigidula with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Brentuximab Vedotin answer

Can you take Adrafinil with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafanil might reduce levels and clinical effects of CYP3A4 substrates.

Full Adrafinil + Brentuximab Vedotin answer

Can you take African Wild Potato with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Full African Wild Potato + Brentuximab Vedotin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Brentuximab Vedotin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Brentuximab Vedotin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Brentuximab Vedotin sits in 1 interaction category. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Brentuximab Vedotin through this category.

About Brentuximab Vedotin

Brentuximab vedotin injection is a targeted cancer medicine given by IV infusion to treat CD30-positive lymphomas, including classical Hodgkin lymphoma, certain T-cell lymphomas and large B-cell lymphoma.

Generic name: Brentuximab Vedotin  ·  Brand name: Adcetris.

See the full Brentuximab Vedotin Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Brentuximab Vedotin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Brentuximab Vedotin.

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Pharmacist Counseling Corner

Brentuximab Vedotin & Supplements: Common Questions

What supplements interact with Brentuximab Vedotin?
Our database currently documents 121 ingredients with a known Brentuximab Vedotin interaction (2 major, 87 moderate, 32 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 121. The highest-ranked right now: Grapefruit, St. John's Wort, Cannabidiol (cbd).
Which Brentuximab Vedotin supplement interactions are the most serious?
The 2 major-rated combinations — led by Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Brentuximab Vedotin?
Plenty of supplements coexist fine with Brentuximab Vedotin; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Adcetris have the same supplement interactions as Brentuximab Vedotin?
Yes — Adcetris all contain Brentuximab Vedotin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Brentuximab Vedotin and my other medications?
This page covers Brentuximab Vedotin against supplements and herbal ingredients. Checking Brentuximab Vedotin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Brentuximab Vedotin Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.