Medication interaction hub

What Supplements Interact with Brentuximab Vedotin?

Brentuximab Vedotin brand name: Adcetris. Every interaction below applies to the brands too.

121 Interactions 2 Major 87 Moderate 32 Minor
Curated & coded by · Clinical Pharmacist · Updated September 16, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Brentuximab Vedotin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Brentuximab Vedotin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Every entry on this page traces back to a single enzyme. Brentuximab vedotin (Adcetris), an IV treatment for Hodgkin lymphoma and certain other lymphomas, carries a chemotherapy payload the body clears through CYP3A4, and I would treat this list with real care. Grapefruit blocks that enzyme and can let the payload build up, raising the risk of serious side effects, while St. John's wort speeds it up and can quietly weaken the treatment itself. Those two are the ones to learn first.

Most of the rest lean the same two ways, nudging drug levels up or down, though much of that evidence comes from lab research rather than patients. With a cancer treatment, both directions matter, so run any supplement past the oncology team first. Of the 121 ingredients on file, only those two rate major, with 87 moderate and 32 minor behind them.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 87 Minor 32 No known interaction 1,331

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Brentuximab Vedotin: Top Interactions at a Glance

The most significant Brentuximab Vedotin supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 121 interacting ingredients — plus 1,331 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Brentuximab Vedotin + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Brentuximab Vedotini

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable St. John's Wort + Brentuximab Vedotini

St.

Read the full interaction
The complete list

Every Supplement Checked Against Brentuximab Vedotin

All 1,452 ingredients in our database, ranked by severity — 121 with a Brentuximab Vedotin interaction on file and 1,331 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Brentuximab Vedotin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Sulforaphane with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Brentuximab Vedotin answer

Can you take Sweet Annie with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Brentuximab Vedotin answer

Can you take Syrian Rue with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Syrian Rue + Brentuximab Vedotin answer

Can you take Terminalia with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Brentuximab Vedotin answer

Can you take Thunder God Vine with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Full Thunder God Vine + Brentuximab Vedotin answer

Can you take Turmeric with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Brentuximab Vedotin answer

Can you take Uva Ursi with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Brentuximab Vedotin answer

Can you take Vitamin E with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Brentuximab Vedotin answer

Can you take White Pepper with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Brentuximab Vedotin answer

Can you take Wild Cherry with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Brentuximab Vedotin answer

Can you take Zedoary with Brentuximab Vedotin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Brentuximab Vedotin answer

Can you take Aegeline with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Brentuximab Vedotin answer

Can you take Ashwagandha with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Brentuximab Vedotin answer

Can you take Atractylodes with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might increase the levels of CYP3A4 substrates.

Full Atractylodes + Brentuximab Vedotin answer

Can you take Bael with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael and its constituents marmelosin and marmesinin inhibited cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Bael + Brentuximab Vedotin answer

Can you take Breadfruit with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more i...

Full Breadfruit + Brentuximab Vedotin answer

Can you take Cascara Sagrada with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.

Full Cascara Sagrada + Brentuximab Vedotin answer

Can you take Fucus Vesiculosus with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Brentuximab Vedotin answer

Can you take Hemp with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.

Full Hemp + Brentuximab Vedotin answer

Can you take Hibiscus Sabdariffa with Brentuximab Vedotin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Brentuximab Vedotin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Brentuximab Vedotin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Brentuximab Vedotin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Brentuximab Vedotin sits in 1 interaction category. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Brentuximab Vedotin through this category.

About Brentuximab Vedotin

Brentuximab vedotin is an antibody-drug conjugate used to treat several types of Hodgkin lymphoma, T-cell lymphomas, and large B-cell lymphoma in adults and certain pediatric patients.

Generic name: Brentuximab Vedotin  ·  Brand name: Adcetris.

See the full Brentuximab Vedotin Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Brentuximab Vedotin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Brentuximab Vedotin.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Brentuximab Vedotin & Supplements: Common Questions

What supplements interact with Brentuximab Vedotin?
Our database currently documents 121 ingredients with a known Brentuximab Vedotin interaction (2 major, 87 moderate, 32 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 121. The highest-ranked right now: Grapefruit, St. John's Wort, Cannabidiol (cbd).
Which Brentuximab Vedotin supplement interactions are the most serious?
The 2 major-rated combinations — led by Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Brentuximab Vedotin?
Plenty of supplements coexist fine with Brentuximab Vedotin; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Adcetris have the same supplement interactions as Brentuximab Vedotin?
Yes — Adcetris all contain Brentuximab Vedotin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Brentuximab Vedotin and my other medications?
This page covers Brentuximab Vedotin against supplements and herbal ingredients. Checking Brentuximab Vedotin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Brentuximab Vedotin Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 16, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.