Medication interaction hub

What Supplements Interact with ADO-Trastuzumab Emtansine?

ADO-Trastuzumab Emtansine brand name: Kadcyla. Every interaction below applies to the brands too.

121 Interactions 2 Major 87 Moderate 32 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with ADO-Trastuzumab Emtansine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check ADO-Trastuzumab Emtansine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you're taking ado-trastuzumab emtansine (Kadcyla) for HER2-positive breast cancer, treat this list as one to check carefully, not casually. Every one of the 121 flagged ingredients affects the same enzyme, CYP3A4, which your body uses to clear part of this medicine. Two carry major ratings: grapefruit, which can drive drug levels up and raise the risk of side effects, and St. John's wort, which can pull levels down and blunt the treatment itself.

The remaining 87 moderate and 32 minor entries work through that same pathway, just with weaker or less certain evidence behind them. Some may raise levels while others may lower them, and with a cancer therapy both directions matter, since more drug means more toxicity and less drug means less benefit. Skip grapefruit outright, and run your full supplement list past your oncology pharmacist before adding a product.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 87 Minor 32 No known interaction 1,331

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

ADO-Trastuzumab Emtansine: Top Interactions at a Glance

The ADO-Trastuzumab Emtansine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 121 interacting ingredients — plus 1,331 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked ADO-Trastuzumab Emtansine Combinations Today

The ADO-Trastuzumab Emtansine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Goldenseal + ADO-Trastuzumab Emtansinei

Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Passion Flower + ADO-Trastuzumab Emtansinei

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Boswellia Serrata + ADO-Trastuzumab Emtansinei

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Unlikely Pomegranate + ADO-Trastuzumab Emtansinei

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically signif...

Read the full interaction Moderate Likelihood Possible False Unicorn + ADO-Trastuzumab Emtansinei

In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Read the full interaction Major Likelihood Likely Grapefruit + ADO-Trastuzumab Emtansinei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against ADO-Trastuzumab Emtansine

All 1,452 ingredients in our database, ranked by severity — 121 with a ADO-Trastuzumab Emtansine interaction on file and 1,331 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With ADO-Trastuzumab Emtansine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Goldenseal with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + ADO-Trastuzumab Emtansine answer

Can you take Passion Flower with ADO-Trastuzumab Emtansine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + ADO-Trastuzumab Emtansine answer

Can you take Boswellia Serrata with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + ADO-Trastuzumab Emtansine answer

Can you take Pomegranate with ADO-Trastuzumab Emtansine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + ADO-Trastuzumab Emtansine answer

Can you take False Unicorn with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + ADO-Trastuzumab Emtansine answer

Can you take Bishop's Weed with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + ADO-Trastuzumab Emtansine answer

Can you take Bitter Orange with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + ADO-Trastuzumab Emtansine answer

Can you take Black Pepper with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + ADO-Trastuzumab Emtansine answer

Can you take Bog Labrador Tea with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + ADO-Trastuzumab Emtansine answer

Can you take Bulbine Natalensis with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + ADO-Trastuzumab Emtansine answer

Can you take Calamus with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + ADO-Trastuzumab Emtansine answer

Can you take Cannabis with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + ADO-Trastuzumab Emtansine answer

Can you take Cat's Claw with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + ADO-Trastuzumab Emtansine answer

Can you take Ceylon Leadwort with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + ADO-Trastuzumab Emtansine answer

Can you take Chanca Piedra with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + ADO-Trastuzumab Emtansine answer

Can you take Chokeberry with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + ADO-Trastuzumab Emtansine answer

Can you take Clove with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + ADO-Trastuzumab Emtansine answer

Can you take Coleus with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + ADO-Trastuzumab Emtansine answer

Can you take Corydalis Yanhusuo with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + ADO-Trastuzumab Emtansine answer

Can you take Cranberry with ADO-Trastuzumab Emtansine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + ADO-Trastuzumab Emtansine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) ADO-Trastuzumab Emtansine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by ADO-Trastuzumab Emtansine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

ADO-Trastuzumab Emtansine sits in 1 interaction category. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach ADO-Trastuzumab Emtansine through this category.

About ADO-Trastuzumab Emtansine

Ado-trastuzumab emtansine is a targeted cancer medicine used to treat HER2-positive metastatic breast cancer and HER2-positive early breast cancer.

Generic name: ADO-Trastuzumab Emtansine  ·  Brand name: Kadcyla.

See the full Ado-trastuzumab Emtansine Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against ADO-Trastuzumab Emtansine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against ADO-Trastuzumab Emtansine.

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Pharmacist Counseling Corner

ADO-Trastuzumab Emtansine & Supplements: Common Questions

What supplements interact with ADO-Trastuzumab Emtansine?
More than you might expect — 121 in total, though they are far from equal: 2 are rated major, 87 moderate, and 32 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, St. John's Wort, Cannabidiol (cbd).
Which ADO-Trastuzumab Emtansine supplement interactions are the most serious?
The 2 major-rated combinations — led by Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on ADO-Trastuzumab Emtansine?
Usually yes — most people on ADO-Trastuzumab Emtansine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Kadcyla have the same supplement interactions as ADO-Trastuzumab Emtansine?
Yes — Kadcyla all contain ADO-Trastuzumab Emtansine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about ADO-Trastuzumab Emtansine and my other medications?
This page covers ADO-Trastuzumab Emtansine against supplements and herbal ingredients. Checking ADO-Trastuzumab Emtansine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ado-trastuzumab Emtansine Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.