Drug & supplement interaction

Ash + ADO-Trastuzumab Emtansine

ADO-Trastuzumab Emtansine brand name: Kadcyla.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Ash and ADO-Trastuzumab Emtansine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ash and ADO-Trastuzumab Emtansine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between ADO-Trastuzumab Emtansine and Ash in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ash safety at a glance

Ash overall Use caution Likely fine in food amounts, but medicinal use lacks strong safety data.

Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.

Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining ADO-Trastuzumab Emtansine and Ash? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for ADO-Trastuzumab Emtansine

Interactions in our licensed database are recorded against drug classes, not just single drug names. ADO-Trastuzumab Emtansine is filed under a single classification — cytochrome p450 3a4 (cyp3a4) substrates. Ash has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of ADO-Trastuzumab Emtansine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ash Does Interact With Other Medications

Ash has 258 moderate known drug interactions in our database — ADO-Trastuzumab Emtansine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 258 No known interaction 2,572 (incl. ADO-Trastuzumab Emtansine)

Taking anything else?

Check Another of Your Medications Against Ash

Covers the 2,830 medications we’ve checked against Ash. Pick one to open its full report.

What to actually watch for

What ADO-Trastuzumab Emtansine’s Own FDA Label Lists

This is not an interaction — none of it involves Ash. These are the most notable effects listed in the ADVERSE REACTIONS section of ADO-Trastuzumab Emtansine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

Low potassium Worth acting on
Yellowing of the skin or eyes Worth acting on
A low platelet count Worth acting on mentioned in 5.7% of FDA reports for ADO-Trastuzumab Emtansine
Chest pain Worth acting on
Anemia Worth acting on
Raised blood pressure Worth acting on
Shortness of breath Worth acting on
A low white blood cell count Worth acting on
Liver problems Worth acting on
Bleeding or bruising Worth acting on

Showing the 10 most notable of 39 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for ADO-Trastuzumab Emtansine. Read the label on DailyMed › Where a percentage is shown, it is the share of 8,277 voluntary FDA FAERS reports for ADO-Trastuzumab Emtansine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Ash’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Ash side to compare — that is a limit of the record, not a statement that Ash has no side effects.

Everything else you take

See Every Supplement That Interacts With ADO-Trastuzumab Emtansine

This page covers Ash only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the ADO-Trastuzumab Emtansine page lists 121 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 87 moderate · 32 minor.

From our pharmacist’s overview on the ADO-Trastuzumab Emtansine page

“If you're taking ado-trastuzumab emtansine (Kadcyla) for HER2-positive breast cancer, treat this list as one to check carefully, not casually. Every one of the 121 flagged ingredients affects the same enzyme, CYP3A4, which your body uses to clear part of this medicine.”

Reviewed by 2 · Jul 18, 2026

Open the ADO-Trastuzumab Emtansine interaction page

One more smart check

Taking Ash as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Ash, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ash. Even though Ash itself has no known interaction with ADO-Trastuzumab Emtansine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ash and ADO-Trastuzumab Emtansine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ash

Steady interest

#831 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication ADO-Trastuzumab Emtansine

Steady interest

#1,707 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ash reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ash and ADO-Trastuzumab Emtansine records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Ash

What is Ash?

Joint pain and arthritis
Fever
Constipation
Fluid retention (diuretic)
Bladder and urinary complaints
Weight management and blood sugar

Ash (Fraxinus excelsior and related species) is a tree whose leaves, bark, and seeds have a long history in folk medicine for arthritis, fever, and fluid retention. Solid human evidence is limited for nearly all of these uses, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Fraxinus excelsior · Oleaceae · Leaves, bark, and seeds · Tea, dried leaf, capsules, tinctures, extracts

An interaction check asks whether these two react with each other — it does not ask whether Ash is a good idea for someone in your situation. Here is what our Ash record says about it on its own.

Ash: dosing

There is no well-established standard dose for ash. Amounts vary widely between teas, tinctures, capsules, and extracts.If you choose to use an ash product, follow the directions on the label and do not exceed them.

From our Ash monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ash monograph & all interactions

Medication

About Ado-trastuzumab Emtansine Injection

What Is Ado-trastuzumab Emtansine Injection Used For?

Brand name: Kadcyla

Kadcyla (ado-trastuzumab emtansine) is used to treat two types of HER2-positive breast cancer. In metastatic breast cancer — cancer that has spread to other parts of the body — it is used when patients have already received trastuzumab and a taxane chemotherapy, either together or separately.

Kadcyla is also used as an adjuvant (post-surgery) treatment for HER2-positive early breast cancer in patients who still had remaining invasive cancer after receiving neoadjuvant (pre-surgery) taxane- and trastuzumab-based treatment. Patients must be selected based on an FDA-authorized HER2 test before starting Kadcyla.

Most-Reported Side Effects for ADO-Trastuzumab Emtansine

From FAERS, the FDA’s public side-effect reporting system (8,277 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 781 reports

Fatigue 751 reports

Nausea 732 reports

Diarrhea 594 reports

Thrombocytopenia 468 reports

See full Ado-trastuzumab Emtansine Injection drug information

Keep checking

Other Drugs & Ash

Browse every other medication we’ve checked against Ash — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

258Moderate

0Minor

2,571No known interaction

258 Moderate 2,571 No interaction

Moderate

258 interactions

Showing 60 of 258 moderate interactions — see all 258 on the Ash page.

No interaction 2,571 drugs checked — show the list

We also checked Ash against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Ash list.

See the full Ash interactions page

See every supplement checked against ADO-Trastuzumab Emtansine, ranked by severity

Evidence & sources

Ash References

The 3 references that drive our Ash monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Zulet MA, Navas-Carretero S, Lara y Sánchez D, et al. A Fraxinus excelsior L. seeds/fruits extract benefits glucose homeostasis and adiposity related markers in elderly overweight/obese subjects: a longitudinal, randomized, crossover, double-blind,
Montó F, Arce C, Noguera MA, et al. Action of an extract from the seeds of Fraxinus excelsior L. on metabolic disorders in hypertensive and obese animal models. Food Funct. 2014;5(4):786-96. PubMed
Visen P, Saraswat B, Visen A, et al. Acute effects of Fraxinus excelsior L. seed extract on postprandial glycemia and insulin secretion on healthy volunteers. J Ethnopharmacol. 2009;126(2):226-32. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ash and ADO-Trastuzumab Emtansine Together: Common Questions

Is it safe to take Ash with ADO-Trastuzumab Emtansine?

We do not list a known interaction between Ash and ADO-Trastuzumab Emtansine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Ash and ADO-Trastuzumab Emtansine combination checked?

Interactions in our licensed database are recorded against drug classes. ADO-Trastuzumab Emtansine is filed under 1 classification, and Ash has documented interactions with 2 drug classes — none of ADO-Trastuzumab Emtansine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Ash interact with any other medications?

Yes. Ash has 258 documented drug interactions in our database — ADO-Trastuzumab Emtansine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does ADO-Trastuzumab Emtansine interact with any supplements?

Yes. ADO-Trastuzumab Emtansine has documented interactions with 121 supplements in our database — Ash is not one of them. The ADO-Trastuzumab Emtansine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ash monograph Uses, safety profile, and every drug interaction in one place Ado-trastuzumab Emtansine Injection drug information The full plain-English guide to this medication ADO-Trastuzumab Emtansine supplement interactions Every supplement checked against ADO-Trastuzumab Emtansine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About ADO-Trastuzumab Emtansine and Ash?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.