Drug & supplement interaction

Ash + acetaminophen, dextromethorphan, doxylamine

acetaminophen, dextromethorphan, doxylamine brand name: NyQuil.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Ash and acetaminophen, dextromethorphan, doxylamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ash and acetaminophen, dextromethorphan, doxylamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between acetaminophen, dextromethorphan, doxylamine and Ash in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ash safety at a glance

Ash overall Use caution Likely fine in food amounts, but medicinal use lacks strong safety data.

Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.

Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining acetaminophen, dextromethorphan, doxylamine and Ash? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for acetaminophen, dextromethorphan, doxylamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. acetaminophen, dextromethorphan, doxylamine is filed under 4 classifications — including cns depressants, oral drugs. Ash has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of acetaminophen, dextromethorphan, doxylamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ash Does Interact With Other Medications

Ash has 258 moderate known drug interactions in our database — acetaminophen, dextromethorphan, doxylamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 258 No known interaction 2,572 (incl. acetaminophen, dextromethorphan, doxylamine)

Taking anything else?

Check Another of Your Medications Against Ash

Covers the 2,830 medications we’ve checked against Ash. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With acetaminophen, dextromethorphan, doxylamine

This page covers Ash only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the acetaminophen, dextromethorphan, doxylamine page lists 106 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 8 major · 78 moderate · 20 minor.

From our pharmacist’s overview on the acetaminophen, dextromethorphan, doxylamine page

“NyQuil (acetaminophen, dextromethorphan, doxylamine) is designed to make you drowsy, and that is exactly where most of its supplement interactions live. Seventy-eight of the 106 ingredients on this list add to its sedation, and the eight rated major, alcohol and kava among them, can push a nighttime cold remedy toward serious depressio…”

Reviewed by 2 · Jul 18, 2026

Open the acetaminophen, dextromethorphan, doxylamine interaction page

One more smart check

Taking Ash as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Ash, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ash. Even though Ash itself has no known interaction with acetaminophen, dextromethorphan, doxylamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ash and acetaminophen, dextromethorphan, doxylamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ash

Steady interest

#840 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication acetaminophen, dextromethorphan, doxylamine

Top 5%

#77 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ash reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ash and acetaminophen, dextromethorphan, doxylamine records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Ash

What is Ash?

Joint pain and arthritis
Fever
Constipation
Fluid retention (diuretic)
Bladder and urinary complaints
Weight management and blood sugar

Ash (Fraxinus excelsior and related species) is a tree whose leaves, bark, and seeds have a long history in folk medicine for arthritis, fever, and fluid retention. Solid human evidence is limited for nearly all of these uses, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Fraxinus excelsior · Oleaceae · Leaves, bark, and seeds · Tea, dried leaf, capsules, tinctures, extracts

An interaction check asks whether these two react with each other — it does not ask whether Ash is a good idea for someone in your situation. Here is what our Ash record says about it on its own.

Ash: dosing

There is no well-established standard dose for ash. Amounts vary widely between teas, tinctures, capsules, and extracts.If you choose to use an ash product, follow the directions on the label and do not exceed them.

From our Ash monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ash monograph & all interactions

Keep checking

Other Drugs & Ash

Browse every other medication we’ve checked against Ash — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

258Moderate

0Minor

2,571No known interaction

258 Moderate 2,571 No interaction

Moderate

258 interactions

Showing 60 of 258 moderate interactions — see all 258 on the Ash page.

No interaction 2,571 drugs checked — show the list

We also checked Ash against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Ash list.

See the full Ash interactions page

See every supplement checked against acetaminophen, dextromethorphan, doxylamine, ranked by severity

Evidence & sources

Ash References

The 3 references that drive our Ash monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Zulet MA, Navas-Carretero S, Lara y Sánchez D, et al. A Fraxinus excelsior L. seeds/fruits extract benefits glucose homeostasis and adiposity related markers in elderly overweight/obese subjects: a longitudinal, randomized, crossover, double-blind,
Montó F, Arce C, Noguera MA, et al. Action of an extract from the seeds of Fraxinus excelsior L. on metabolic disorders in hypertensive and obese animal models. Food Funct. 2014;5(4):786-96. PubMed
Visen P, Saraswat B, Visen A, et al. Acute effects of Fraxinus excelsior L. seed extract on postprandial glycemia and insulin secretion on healthy volunteers. J Ethnopharmacol. 2009;126(2):226-32. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ash and acetaminophen, dextromethorphan, doxylamine Together: Common Questions

Is it safe to take Ash with acetaminophen, dextromethorphan, doxylamine?

We do not list a known interaction between Ash and acetaminophen, dextromethorphan, doxylamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Ash and acetaminophen, dextromethorphan, doxylamine combination checked?

Interactions in our licensed database are recorded against drug classes. acetaminophen, dextromethorphan, doxylamine is filed under 4 classifications, and Ash has documented interactions with 2 drug classes — none of acetaminophen, dextromethorphan, doxylamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Ash interact with any other medications?

Yes. Ash has 258 documented drug interactions in our database — acetaminophen, dextromethorphan, doxylamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does acetaminophen, dextromethorphan, doxylamine interact with any supplements?

Yes. acetaminophen, dextromethorphan, doxylamine has documented interactions with 106 supplements in our database — Ash is not one of them. The acetaminophen, dextromethorphan, doxylamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ash monograph Uses, safety profile, and every drug interaction in one place acetaminophen, dextromethorphan, doxylamine supplement interactions Every supplement checked against acetaminophen, dextromethorphan, doxylamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About acetaminophen, dextromethorphan, doxylamine and Ash?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.