Medication interaction hub

What Supplements Interact with acetaminophen, dextromethorphan, doxylamine?

acetaminophen, dextromethorphan, doxylamine brand name: NyQuil. Every interaction below applies to the brands too.

106 Interactions 8 Major 78 Moderate 20 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with acetaminophen, dextromethorphan, doxylamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check acetaminophen, dextromethorphan, doxylamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

NyQuil (acetaminophen, dextromethorphan, doxylamine) is designed to make you drowsy, and that is exactly where most of its supplement interactions live. Seventy-eight of the 106 ingredients on this list add to its sedation, and the eight rated major, alcohol and kava among them, can push a nighttime cold remedy toward serious depression of breathing and the nervous system. These combinations warrant real care, and the eight major entries are the ones to understand first.

The quieter entries still matter. Grapefruit slows the breakdown of dextromethorphan and raises its levels, while charcoal products and bulky fiber supplements can trap oral medicines before they absorb, so keep them well separated from any dose. Even a daily diet heavy in certain vegetables can speed acetaminophen out of the body and blunt its effect. Of the 106 entries, 78 are moderate and 20 minor, but the sedative overlaps are where the danger concentrates.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 78 Minor 20 No known interaction 1,346

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

acetaminophen, dextromethorphan, doxylamine: Top Interactions at a Glance

The acetaminophen, dextromethorphan, doxylamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 106 interacting ingredients — plus 1,346 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked acetaminophen, dextromethorphan, doxylamine Combinations Today

The acetaminophen, dextromethorphan, doxylamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Lemon Balm + acetaminophen, dextromethorphan, doxylaminei

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Read the full interaction Moderate Likelihood Possible Ashwagandha + acetaminophen, dextromethorphan, doxylaminei

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Read the full interaction Major Likelihood Probable Kava + acetaminophen, dextromethorphan, doxylaminei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction Moderate Likelihood Possible Bay Leaf + acetaminophen, dextromethorphan, doxylaminei

Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Read the full interaction Major Likelihood Likely Beer + acetaminophen, dextromethorphan, doxylaminei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + acetaminophen, dextromethorphan, doxylaminei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against acetaminophen, dextromethorphan, doxylamine

All 1,452 ingredients in our database, ranked by severity — 106 with a acetaminophen, dextromethorphan, doxylamine interaction on file and 1,346 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With acetaminophen, dextromethorphan, doxylamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Lemon Balm with acetaminophen, dextromethorphan, doxylamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Full Lemon Balm + acetaminophen, dextromethorphan, doxylamine answer

Can you take Ashwagandha with acetaminophen, dextromethorphan, doxylamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + acetaminophen, dextromethorphan, doxylamine answer

Can you take Kava with acetaminophen, dextromethorphan, doxylamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + acetaminophen, dextromethorphan, doxylamine answer

Can you take Bay Leaf with acetaminophen, dextromethorphan, doxylamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + acetaminophen, dextromethorphan, doxylamine answer

Can you take Rhodiola with acetaminophen, dextromethorphan, doxylamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.

Full Rhodiola + acetaminophen, dextromethorphan, doxylamine answer

Can you take Xanthan Gum with acetaminophen, dextromethorphan, doxylamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + acetaminophen, dextromethorphan, doxylamine answer

Can you take Baikal Skullcap with acetaminophen, dextromethorphan, doxylamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative propert...

Full Baikal Skullcap + acetaminophen, dextromethorphan, doxylamine answer

Can you take Calendula with acetaminophen, dextromethorphan, doxylamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.

Full Calendula + acetaminophen, dextromethorphan, doxylamine answer

Can you take Gamma-aminobutyric Acid (gaba) with acetaminophen, dextromethorphan, doxylamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Full Gamma-aminobutyric Acid (gaba) + acetaminophen, dextromethorphan, doxylamine answer

Can you take Theanine with acetaminophen, dextromethorphan, doxylamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.

Full Theanine + acetaminophen, dextromethorphan, doxylamine answer

Can you take Beer with acetaminophen, dextromethorphan, doxylamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Beer + acetaminophen, dextromethorphan, doxylamine answer

Can you take Wine with acetaminophen, dextromethorphan, doxylamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Wine + acetaminophen, dextromethorphan, doxylamine answer

Can you take 1,4-butanediol with acetaminophen, dextromethorphan, doxylamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + acetaminophen, dextromethorphan, doxylamine answer

Can you take Activated Charcoal with acetaminophen, dextromethorphan, doxylamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + acetaminophen, dextromethorphan, doxylamine answer

Can you take Gamma-hydroxybutyrate (ghb) with acetaminophen, dextromethorphan, doxylamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + acetaminophen, dextromethorphan, doxylamine answer

Can you take Grapefruit with acetaminophen, dextromethorphan, doxylamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase blood levels of dextromethorphan, potentially increasing the effects and adverse effects of dextromethorphan.

Full Grapefruit + acetaminophen, dextromethorphan, doxylamine answer

Can you take L-tryptophan with acetaminophen, dextromethorphan, doxylamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.

Full L-tryptophan + acetaminophen, dextromethorphan, doxylamine answer

Can you take Brussels Sprout with acetaminophen, dextromethorphan, doxylamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. A cabbage and Brussels sprout-containing diet can increase metabolism and decrease levels of acetaminophen.

Full Brussels Sprout + acetaminophen, dextromethorphan, doxylamine answer

Can you take Cabbage with acetaminophen, dextromethorphan, doxylamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cabbage might increase clearance and reduce the effects of acetaminophen.

Full Cabbage + acetaminophen, dextromethorphan, doxylamine answer

Can you take Coffee Charcoal with acetaminophen, dextromethorphan, doxylamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + acetaminophen, dextromethorphan, doxylamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) acetaminophen, dextromethorphan, doxylamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by acetaminophen, dextromethorphan, doxylamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

acetaminophen, dextromethorphan, doxylamine sits in 4 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach acetaminophen, dextromethorphan, doxylamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach acetaminophen, dextromethorphan, doxylamine through this category.

Dextromethorphan (Robitussin Dm, Others) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach acetaminophen, dextromethorphan, doxylamine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach acetaminophen, dextromethorphan, doxylamine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against acetaminophen, dextromethorphan, doxylamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against acetaminophen, dextromethorphan, doxylamine.

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Pharmacist Counseling Corner

acetaminophen, dextromethorphan, doxylamine & Supplements: Common Questions

What supplements interact with acetaminophen, dextromethorphan, doxylamine?
More than you might expect — 106 in total, though they are far from equal: 8 are rated major, 78 moderate, and 20 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which acetaminophen, dextromethorphan, doxylamine supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on acetaminophen, dextromethorphan, doxylamine?
Usually yes — most people on acetaminophen, dextromethorphan, doxylamine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like NyQuil have the same supplement interactions as acetaminophen, dextromethorphan, doxylamine?
Yes — NyQuil all contain acetaminophen, dextromethorphan, doxylamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about acetaminophen, dextromethorphan, doxylamine and my other medications?
This page covers acetaminophen, dextromethorphan, doxylamine against supplements and herbal ingredients. Checking acetaminophen, dextromethorphan, doxylamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.