Drug & supplement interaction

Khat + acetaminophen, dextromethorphan, doxylamine

acetaminophen, dextromethorphan, doxylamine brand name: NyQuil.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Khat and acetaminophen, dextromethorphan, doxylamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Khat and acetaminophen, dextromethorphan, doxylamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between acetaminophen, dextromethorphan, doxylamine and Khat in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Khat safety at a glance

Khat overall Avoid Khat is an addictive stimulant linked to serious health harms and is illegal in many countries.

Pregnancy Possibly Unsafe When used orally. Khat has been associated with reducing maternal food intake, maternal weight, infant birth weight, and placental blood flow. It has also been... Read the full pregnancy detail

Breastfeeding Possibly Unsafe When used orally. Khat has been associated with a reduction in breast milk production. Also, khat contains compounds that are metabolized to norpseudoephedrine,... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining acetaminophen, dextromethorphan, doxylamine and Khat? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for acetaminophen, dextromethorphan, doxylamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. acetaminophen, dextromethorphan, doxylamine is filed under 4 classifications — including cns depressants, oral drugs. Khat has documented interactions with 7 drug classes — the most serious being amoxicillin (amoxil, trimox) (major), antihypertensive drugs (moderate) and antipsychotic drugs (moderate) — and none of acetaminophen, dextromethorphan, doxylamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Khat Does Interact With Other Medications

Khat has 4 major, 401 moderate known drug interactions in our database — acetaminophen, dextromethorphan, doxylamine isn’t one of them. If you take anything else, check it against the full list below.

Major 4 Moderate 401 No known interaction 2,425 (incl. acetaminophen, dextromethorphan, doxylamine)

Taking anything else?

Check Another of Your Medications Against Khat

Covers the 2,830 medications we’ve checked against Khat. Pick one to open its full report.

What to actually watch for

What Khat Itself Has Been Linked To

This is not an interaction — nothing below involves acetaminophen, dextromethorphan, doxylamine. It is the side-effect record for Khat on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Khat, this list is the first place to look. 7 entries are worth acting on rather than waiting out — marked below.

Mania or an unusually elevated mood Worth acting on Additional detail
“Orally, Khat has been associated with euphoria, excessive talkativeness, hyperactivity, aggressiveness, anxiety, elevated blood pressure, tachycardia, and manic behavior. High doses of khat have been reported to cause depressed mood, paranoia and psychosis.”

Khat · Natural Medicines adverse-effect record, reported in anxiety.
6 sources cited

10120. Randall T. Khat abuse fuels Somali conflict, drains economy. JAMA 1993;269:12-13. DOI

57391. Hassan, N. A., Gunaid, A. A., El Khally, F. M., and Murray-Lyon, I. M. The effect of chewing Khat leaves on human mood. Saudi.Med.J. 2002;23(7):850-853. DOI

57410. Granek, M., Shalev, A., and Weingarten, A. M. Khat-induced hypnagogic hallucinations. Acta Psychiatr.Scand. 1988;78(4):458-461. PubMed

57420. Jager, A. D. and Sireling, L. Natural history of Khat psychosis. Aust.N.Z.J.Psychiatry 1994;28(2):331-332. PubMed

57422. Yousef, G., Huq, Z., and Lambert, T. Khat chewing as a cause of psychosis. Br.J.Hosp.Med. 10-4-1995;54(7):322-326.

6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
“Orally, khat can cause euphoria, excessive talkativeness, hyperactivity, aggressiveness, anxiety, and manic behavior. After use, insomnia, malaise, and lack of concentration have been reported (6). Khat has been reported to cause migraine and cerebral hemorrhage (6).

Rarely, khat has been associated with encephalopathy, intraparenchymal brain hemorrhage, and reversible cerebral vasoconstriction syndrome (RCVS).”

Khat · Natural Medicines adverse-effect record, reported in anxiety.
4 sources cited

6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

95230. Baharith H, Zarrin A. Khat - a new precipitating factor for reversible cerebral vasoconstriction syndrome: a case report. J Med Case Rep. 2016;10(1):351. PubMed

95240. Tuladhar AM, Boogaarts HD, de Leeuw FE, van Dijk E. Reversible cerebral vasoconstriction syndrome after chewing khat leaves. Cerebrovasc Dis. 2013;36(2):158-9. PubMed

98511. Bede P, El-Kininy N, O'Hara F, Menon P, Finegan E, Healy D. 'Khatatonia' - cathinone-induced hypertensive encephalopathy. Neth J Med. 2017;75(10):448-450.
Dependence or withdrawal symptoms / Hallucinations / Low mood Worth acting on Additional detail
“Orally, khat has been reported to cause mood swings and depressed mood. High doses of khat have been reported to cause paranoia and psychosis, including strange experiences and hallucinations. In one cross-sectional study, such symptoms occurred more frequently in female and younger khat chewers.”

Khat · Natural Medicines adverse-effect record, reported in depression.
6 sources cited

57391. Hassan, N. A., Gunaid, A. A., El Khally, F. M., and Murray-Lyon, I. M. The effect of chewing Khat leaves on human mood. Saudi.Med.J. 2002;23(7):850-853. DOI

10120. Randall T. Khat abuse fuels Somali conflict, drains economy. JAMA 1993;269:12-13. DOI

57410. Granek, M., Shalev, A., and Weingarten, A. M. Khat-induced hypnagogic hallucinations. Acta Psychiatr.Scand. 1988;78(4):458-461. PubMed

57420. Jager, A. D. and Sireling, L. Natural history of Khat psychosis. Aust.N.Z.J.Psychiatry 1994;28(2):331-332. PubMed

57422. Yousef, G., Huq, Z., and Lambert, T. Khat chewing as a cause of psychosis. Br.J.Hosp.Med. 10-4-1995;54(7):322-326.

106449. Ongeri L, Kirui F, Muniu E, et al. Khat use and psychotic symptoms in a rural Khat growing population in Kenya: a household survey. BMC Psychiatry 2019;19(1):137. PubMed
Thoughts of self-harm Worth acting on Additional detail

Recorded for Khat in the same Natural Medicines adverse-effect record shown under Dependence or withdrawal symptoms / Hallucinations / Low mood above.
Trouble passing urine Worth acting on Additional detail
“Orally, chewing khat has been reported to cause an initial increase in male libido followed by loss of sexual drive, spermatorrhea, and impotence (6). Khat has also been reported to cause urinary retention.”

Khat · Natural Medicines adverse-effect record, reported in erectile dysfunction (ed).
2 sources cited

6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

95237. McLean AS, Kot MB. Cardiac collapse associated with the ingestion of khat. Intern Med J. 2011;41(7):579-81. PubMed
A heart attack / Raised blood pressure Worth acting on Additional detail
“Orally, khat has been reported to cause tachycardia, palpitations, and increased blood pressure; however, tolerance to these effects seems to develop with continued use. Chewing khat for at least 6 hours per day has been associated with an approximately 39-fold increased risk for myocardial infarction (MI).”

Khat · Natural Medicines adverse-effect record, reported in myocardial infarction (mi).
6 sources cited

57388. Hassan, N. A., Gunaid, A. A., Abdo-Rabbo, A. A., Abdel-Kader, Z. Y., al Mansoob, M. A., Awad, A. Y., and Murray-Lyon, I. M. The effect of Qat chewing on blood pressure and heart rate in healthy volunteers. Trop.Doct. 2000;30(2):107-108. PubMed

57403. Hassan, N. A., Gunaid, A. A., El Khally, F. M., Al Noami, M. Y., and Murray-Lyon, I. M. Khat chewing and arterial blood pressure. A randomized controlled clinical trial of alpha-1 and selective beta-1 adrenoceptor blockade. Saudi.Med J 2005;26(4):537-541 DOI

57412. Nencini, P., Ahmed, A. M., Amiconi, G., and Elmi, A. S. Tolerance develops to sympathetic effects of khat in humans. Pharmacology 1984;28(3):150-154. PubMed

98510. Sallam MA, Sheikh KA, Baxendale R, Azam MN, Hossain AM, El-Setouhy M. The physiological and ergogenic effects of khat (Catha edulis Forsk) extract. Subst Use Misuse. 2018;53(1):94-100.

57402. Al Motarreb, A., Briancon, S., Al Jaber, N., Al Adhi, B., Al Jailani, F., Salek, M. S., and Broadley, K. J. Khat chewing is a risk factor for acute myocardial infarction: a case-control study. Br J Clin Pharmacol 2005;59(5):574-581. PubMed

95237. McLean AS, Kot MB. Cardiac collapse associated with the ingestion of khat. Intern Med J. 2011;41(7):579-81. PubMed
Yellowing of the skin or eyes Worth acting on Additional detail
“Orally, chewing khat has been reported to cause livery injury in at least a few dozen cases, with symptoms including jaundice, fatigue, pruritus, anorexia, abdominal pain, and dark urine. In some cases, liver injury has resolved after discontinuation of khat consumption.”

Khat · Natural Medicines adverse-effect record, reported in anorexia.
6 sources cited

95228. Alhaddad OM, Elsabaawy MM, Rewisha EA, et al. Khat-induced liver injuries: A report of two cases. Arab J Gastroenterol. 2016;17(1):45-8. PubMed

95231. Chapman MH, Kajihara M, Borges G, et al. Severe, acute liver injury and khat leaves. N Engl J Med. 2010;362(17):1642-4. PubMed

95234. Forbes MP, Raj AS, Martin J, Lampe G, Powell EE. Khat-associated hepatitis. Med J Aust. 2013;199(7):498-9. PubMed

95238. Peevers CG, Moorghen M, Collins PL, Gordon FH, McCune CA. Liver disease and cirrhosis because of Khat chewing in UK Somali men: a case series. Liver Int. 2010;30(8):1242-3. PubMed

95239. Roelandt P, George C, d'Heygere F, et al. Acute liver failure secondary to khat (Catha edulis)-induced necrotic hepatitis requiring liver transplantation: case report. Transplant Proc. 2011;43(9):3493-5. PubMed

106452. Palacios Argueta P, Attar B, Sikavi C, Alagiozian-Angelova V, Mishra S. Drug-Induced Liver Injury Caused by "Khat," an Herbal Stimulant. ACG Case Rep J 2020;7(11):e00480. PubMed
“Orally, chewing khat has been reported to cause infection from Fasciola hepatica and campylobacter fetus. There are multiple reports of acute liver disease due to fascioliasis, or liver flute infection, in Somalian males living in the Netherlands. Fascioliasis symptoms include abdominal pain, eosinophilia, jaundice, and pruritus and typically resolve after treatment.”

Khat · Natural Medicines adverse-effect record, reported in cirrhosis.
3 sources cited

6464. Cats A, Scholten P, Meuwissen SGM, et al. Acute Fasciola hepatica infection attributed to chewing khat. Gut 2000;47:584-5.

95233. de Bree LC, Bodelier AG, Verburg GP. Fasciola hepatica as a cause of jaundice after chewing khat: a case report. Neth J Med. 2013;71(9):478-9.

95236. Martínez-Balzano C, Kohlitz PJ, Chaudhary P, Hegazy H. Campylobacter fetus bacteremia in a young healthy adult transmitted by khat chewing. J Infect. 2013;66(2):184-6. PubMed
Liver problems Worth acting on Additional detail

Recorded for Khat in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

Showing the 10 most notable of 33 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Khat — expand a row for the licensed statement it rests on. We haven’t matched acetaminophen, dextromethorphan, doxylamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for acetaminophen, dextromethorphan, doxylamine.

Special populations

Khat in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Khat has been associated with reducing maternal food intake, maternal weight, infant birth weight, and placental blood flow. It has also been associated with an increased risk for chest pain, elevated heart rate, and high blood pressure during pregnancy.

Lactation Possibly Unsafe

When used orally. Khat has been associated with a reduction in breast milk production. Also, khat contains compounds that are metabolized to norpseudoephedrine, which passes into breast milk; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With acetaminophen, dextromethorphan, doxylamine

This page covers Khat only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the acetaminophen, dextromethorphan, doxylamine page lists 106 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 8 major · 78 moderate · 20 minor.

From our pharmacist’s overview on the acetaminophen, dextromethorphan, doxylamine page

“NyQuil (acetaminophen, dextromethorphan, doxylamine) is designed to make you drowsy, and that is exactly where most of its supplement interactions live. Seventy-eight of the 106 ingredients on this list add to its sedation, and the eight rated major, alcohol and kava among them, can push a nighttime cold remedy toward serious depressio…”

Reviewed by 2 · Jul 18, 2026

Open the acetaminophen, dextromethorphan, doxylamine interaction page

How much people look this up

Where Khat and acetaminophen, dextromethorphan, doxylamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Khat

Top half

#466 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication acetaminophen, dextromethorphan, doxylamine

Top 5%

#79 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Khat reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Khat and acetaminophen, dextromethorphan, doxylamine records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Khat

What is Khat?

Stimulant for energy and alertness
Euphoria and mood elevation
Reducing fatigue
Appetite suppression
Social and traditional ceremonies

Khat is a plant chewed for its amphetamine-like stimulant effects, but it carries serious risks including high blood pressure, heart problems, mental health effects, and dependence. It is a controlled substance and illegal in the United States and many other countries, so it should not be used.

Catha edulis · Celastraceae · Leaves and young shoots · Fresh leaves for chewing, dried leaves, tea; sometimes smoked

An interaction check asks whether these two react with each other — it does not ask whether Khat is a good idea for someone in your situation. Here is what our Khat record says about it on its own.

Khat: dosing

There is no safe or established dose of khat. It is not a regulated supplement, and the amount of active compounds varies widely depending on the freshness and source of the leaves.Because khat is illegal in the United States and many other countries and carries real health risks, no dosing recommendation can be given.

From our Khat monograph — the full record covers uses, side effects and every documented interaction.

Read the full Khat monograph & all interactions

Keep checking

Other Drugs & Khat

Browse every other medication we’ve checked against Khat — both the ones with a known interaction and the ones without. Select any drug for the full detail.

4Major

401Moderate

0Minor

2,424No known interaction

4 Major 401 Moderate 2,424 No interaction

Major

4 interactions

Moderate

401 interactions

Showing 60 of 401 moderate interactions — see all 401 on the Khat page.

No interaction 2,424 drugs checked — show the list

We also checked Khat against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,424 medications checked with no known interaction — see the full Khat list.

See the full Khat interactions page

See every supplement checked against acetaminophen, dextromethorphan, doxylamine, ranked by severity

Evidence & sources

Khat References

The 47 references that drive our Khat monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
Cats A, Scholten P, Meuwissen SGM, et al. Acute Fasciola hepatica infection attributed to chewing khat. Gut 2000;47:584-5.
Randall T. Khat abuse fuels Somali conflict, drains economy. JAMA 1993;269:12-13. DOI
Attef, O. A., Ali, A. A., and Ali, H. M. Effect of Khat chewing on the bioavailability of ampicillin and amoxycillin. J.Antimicrob.Chemother. 1997;39(4):523-525. PubMed
Hassan, N. A., Gunaid, A. A., Abdo-Rabbo, A. A., Abdel-Kader, Z. Y., al Mansoob, M. A., Awad, A. Y., and Murray-Lyon, I. M. The effect of Qat chewing on blood pressure and heart rate in healthy volunteers. Trop.Doct. 2000;30(2):107-108. PubMed
Al Hadrani, A. M. Khat induced hemorrhoidal disease in Yemen. Saudi.Med.J. 2000;21(5):475-477. DOI
Giannini, A. J. and Nakoneczie, A. M. Treatment of Khat Addiction with Bromocriptine Mesylate: A Case Report and Review of Cocaine- and Amphetamine-Like Effects. Am J Ther 1995;2(7):487-489. PubMed
Hassan, N. A., Gunaid, A. A., El Khally, F. M., and Murray-Lyon, I. M. The effect of chewing Khat leaves on human mood. Saudi.Med.J. 2002;23(7):850-853. DOI
Giannini, A. J., Miller, N. S., and Turner, C. E. Treatment of khat addiction. J.Subst.Abuse Treat. 1992;9(4):379-382. PubMed
Al Motarreb, A., Briancon, S., Al Jaber, N., Al Adhi, B., Al Jailani, F., Salek, M. S., and Broadley, K. J. Khat chewing is a risk factor for acute myocardial infarction: a case-control study. Br J Clin Pharmacol 2005;59(5):574-581. PubMed
Hassan, N. A., Gunaid, A. A., El Khally, F. M., Al Noami, M. Y., and Murray-Lyon, I. M. Khat chewing and arterial blood pressure. A randomized controlled clinical trial of alpha-1 and selective beta-1 adrenoceptor blockade. Saudi.Med J 2005;26(4):537-541 DOI
Brenneisen, R., Fisch, H. U., Koelbing, U., Geisshusler, S., and Kalix, P. Amphetamine-like effects in humans of the khat alkaloid cathinone. Br.J.Clin.Pharmacol. 1990;30(6):825-828. PubMed
Granek, M., Shalev, A., and Weingarten, A. M. Khat-induced hypnagogic hallucinations. Acta Psychiatr.Scand. 1988;78(4):458-461. PubMed
Nencini, P., Ahmed, A. M., Amiconi, G., and Elmi, A. S. Tolerance develops to sympathetic effects of khat in humans. Pharmacology 1984;28(3):150-154. PubMed
Jager, A. D. and Sireling, L. Natural history of Khat psychosis. Aust.N.Z.J.Psychiatry 1994;28(2):331-332. PubMed
Yousef, G., Huq, Z., and Lambert, T. Khat chewing as a cause of psychosis. Br.J.Hosp.Med. 10-4-1995;54(7):322-326.
Griffiths, P., Gossop, M., Wickenden, S., Dunworth, J., Harris, K., and Lloyd, C. A transcultural pattern of drug use: qat (khat) in the UK. Br.J.Psychiatry 1997;170:281-284. PubMed
Alhaddad OM, Elsabaawy MM, Rewisha EA, et al. Khat-induced liver injuries: A report of two cases. Arab J Gastroenterol. 2016;17(1):45-8. PubMed
Alsalahi A, Alshawsh MA, Mohamed R, et al. Conflicting reports on the role of the glycemic effect of Catha edulis (Khat): A systematic review and meta-analysis. J Ethnopharmacol. 2016;186:30-43.
Baharith H, Zarrin A. Khat - a new precipitating factor for reversible cerebral vasoconstriction syndrome: a case report. J Med Case Rep. 2016;10(1):351. PubMed
Chapman MH, Kajihara M, Borges G, et al. Severe, acute liver injury and khat leaves. N Engl J Med. 2010;362(17):1642-4. PubMed
Coton T, Simon F, Oliver M, Kraemer P. Hepatotoxicity of khat chewing. Liver Int. 2011;31(3):434. PubMed
de Bree LC, Bodelier AG, Verburg GP. Fasciola hepatica as a cause of jaundice after chewing khat: a case report. Neth J Med. 2013;71(9):478-9.
Forbes MP, Raj AS, Martin J, Lampe G, Powell EE. Khat-associated hepatitis. Med J Aust. 2013;199(7):498-9. PubMed
Kassim S, Croucher R, al'Absi M. Khat dependence syndrome: a cross sectional preliminary evaluation amongst UK-resident Yemeni khat chewers. J Ethnopharmacol. 2013;146(3):835-41. PubMed
Martínez-Balzano C, Kohlitz PJ, Chaudhary P, Hegazy H. Campylobacter fetus bacteremia in a young healthy adult transmitted by khat chewing. J Infect. 2013;66(2):184-6. PubMed
McLean AS, Kot MB. Cardiac collapse associated with the ingestion of khat. Intern Med J. 2011;41(7):579-81. PubMed
Peevers CG, Moorghen M, Collins PL, Gordon FH, McCune CA. Liver disease and cirrhosis because of Khat chewing in UK Somali men: a case series. Liver Int. 2010;30(8):1242-3. PubMed
Roelandt P, George C, d'Heygere F, et al. Acute liver failure secondary to khat (Catha edulis)-induced necrotic hepatitis requiring liver transplantation: case report. Transplant Proc. 2011;43(9):3493-5. PubMed
Tuladhar AM, Boogaarts HD, de Leeuw FE, van Dijk E. Reversible cerebral vasoconstriction syndrome after chewing khat leaves. Cerebrovasc Dis. 2013;36(2):158-9. PubMed
Manzar MD, Salahuddin M, Sony P, et al. Sleep disturbances and memory impairment among pregnant women consuming khat: An under-recognized problem. Ann Thorac Med. 2017;12(4):247-251. PubMed
Al-Maweri SA, AlAkhali M. Oral hygiene and periodontal health status among khat chewers. A case-control study. J Clin Exp Dent. 2017;9(5):e629-e634. PubMed
Issa FH, Al-Habori M, Chance ML. Effect of Khat (Catha edulis) Use on the Bioavailability, Plasma Levels and Antimalarial Activity of Chloroquine. Sultan Qaboos Univ Med J. 2016;16(2):e182-8. PubMed
Kalakonda B, Al-Maweri SA, Al-Shamiri HM, Ijaz A, Gamal S, Dhaifullah E. Is Khat (Catha edulis) chewing a risk factor for periodontal diseases? A systematic review. J Clin Exp Dent. 2017;9(10):e1264-e1270. PubMed
Al-Akhali MS, Al-Moraissi EA. Khat chewing habit produces a significant adverse effect on periodontal, oral health: A systematic review and meta-analysis. J Periodontal Res. 2017;52(6):937-945. PubMed
Sallam MA, Sheikh KA, Baxendale R, Azam MN, Hossain AM, El-Setouhy M. The physiological and ergogenic effects of khat (Catha edulis Forsk) extract. Subst Use Misuse. 2018;53(1):94-100.
Bede P, El-Kininy N, O'Hara F, Menon P, Finegan E, Healy D. 'Khatatonia' - cathinone-induced hypertensive encephalopathy. Neth J Med. 2017;75(10):448-450.
Woldeamanuel GG, Geta TG. Impact of chronic khat (Catha edulis Forsk) chewing on pulmonary function test and oxygen saturation in humans: A comparative study. SAGE Open Med 2019;7:2050312118824616.
Abdulwadoud Alshoabi S, Noman Aljaber N, Omer Hussain A, Mohammed Aloufi K, Gafar Salih S. Khat Chewing Effect on the International Normalized Ratio in Patients with Mechanical Heart Valves under Warfarin Therapy. Pak J Biol Sci 2020;23(11):1487-1491. PubMed
Badedi M, Darraj H, Hummadi A, et al. Khat Chewing and Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes 2020;13:307-312.
Hakami T, Mahmoud M, Mohammed B, El-Setouhy M. Effects of khat use on response to antipsychotic medications in patients with newly diagnosed schizophrenia: a retrospective study. East Mediterr Health J 2021;27(4):353-360. PubMed
Ongeri L, Kirui F, Muniu E, et al. Khat use and psychotic symptoms in a rural Khat growing population in Kenya: a household survey. BMC Psychiatry 2019;19(1):137. PubMed
Mekuriaw B, Zegeye A, Molla A, Hussen R, Yimer S, Belayneh Z. Prevalence of Common Mental Disorder and Its Association with Khat Chewing among Ethiopian College Students: A Systematic Review and Meta-Analysis. Psychiatry J 2020;2020:1462141. PubMed
Tesfaye E, Krahl W, Alemayehu S. Khat induced psychotic disorder: case report. Subst Abuse Treat Prev Policy 2020;15(1):27. PubMed
Palacios Argueta P, Attar B, Sikavi C, Alagiozian-Angelova V, Mishra S. Drug-Induced Liver Injury Caused by "Khat," an Herbal Stimulant. ACG Case Rep J 2020;7(11):e00480. PubMed
Waters M, Oxner A, Krajden S, Sultanian R. Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male. Case Reports Hepatol 2018;2018:2816907. PubMed
Patel H, Kumar K, Essrani RK, Niazi M, Makker J, Nayudu SK. Acute Hepatitis in a Yemeni Immigrant Associated with Khat: A "Biological Amphetamine" Carried in Cultures. Clin Pract 2021;11(1):167-173. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Khat and acetaminophen, dextromethorphan, doxylamine Together: Common Questions

Is it safe to take Khat with acetaminophen, dextromethorphan, doxylamine?

We do not list a known interaction between Khat and acetaminophen, dextromethorphan, doxylamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Khat and acetaminophen, dextromethorphan, doxylamine combination checked?

Interactions in our licensed database are recorded against drug classes. acetaminophen, dextromethorphan, doxylamine is filed under 4 classifications, and Khat has documented interactions with 7 drug classes — none of acetaminophen, dextromethorphan, doxylamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Khat interact with any other medications?

Yes. Khat has 405 documented drug interactions in our database — acetaminophen, dextromethorphan, doxylamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does acetaminophen, dextromethorphan, doxylamine interact with any supplements?

Yes. acetaminophen, dextromethorphan, doxylamine has documented interactions with 106 supplements in our database — Khat is not one of them. The acetaminophen, dextromethorphan, doxylamine interaction page linked on this page lists every one, ranked by severity.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.