Drug & supplement interaction

Tyramine + acetaminophen, dextromethorphan, doxylamine

acetaminophen, dextromethorphan, doxylamine brand name: NyQuil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Tyramine and acetaminophen, dextromethorphan, doxylamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Tyramine and acetaminophen, dextromethorphan, doxylamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between acetaminophen, dextromethorphan, doxylamine and Tyramine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tyramine safety at a glance

Tyramine overall Use caution Tyramine in normal foods is fine for most people, but it can be harmful for those who are sensitive or taking certain drugs.
Pregnancy Use caution Tyramine from ordinary food is generally fine, but concentrated supplemental use is not recommended and not well studied.
Breastfeeding Use caution Tyramine from a normal diet is generally fine, but deliberately taking it in supplement form is not advised due to a lack of safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining acetaminophen, dextromethorphan, doxylamine and Tyramine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for acetaminophen, dextromethorphan, doxylamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. acetaminophen, dextromethorphan, doxylamine is filed under 4 classifications — including cns depressants, oral drugs. Tyramine has documented interactions with 4 drug classes — the most serious being antihypertensive drugs (major), monoamine oxidase inhibitors (maois) (major) and alcohol (moderate) — and none of acetaminophen, dextromethorphan, doxylamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tyramine Does Interact With Other Medications

Tyramine has 181 major, 1 moderate, 171 minor known drug interactions in our database — acetaminophen, dextromethorphan, doxylamine isn’t one of them. If you take anything else, check it against the full list below.

Major 181 Moderate 1 Minor 171 No known interaction 2,477 (incl. acetaminophen, dextromethorphan, doxylamine)
Taking anything else?

Check Another of Your Medications Against Tyramine

Covers the 2,830 medications we’ve checked against Tyramine. Pick one to open its full report.

What to actually watch for

What Tyramine Itself Has Been Linked To

This is not an interaction — nothing below involves acetaminophen, dextromethorphan, doxylamine. It is the side-effect record for Tyramine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Tyramine, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Dehydration / A heart attack / Chest pain / Raised blood pressure Worth acting on Additional detail

    “Orally and intravenously, unspecified doses of tyramine have increased systolic, but not diastolic, blood pressure. Intravenous tyramine is not used clinically but is commonly used to examine safety and interaction outcomes. A single dose of oral tyramine 400 mg has been reported to cause heart palpitations and elevations in systolic blood pressure in healthy volunteers.”

    Tyramine · Natural Medicines adverse-effect record, reported in angina.

    6 sources cited
    1. 100189. VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9. DOI
    2. 100190. Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31. PubMed
    3. 101013. Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
    4. 101014. Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44. PubMed
    5. 105519. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed
    6. 101018. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
  • Blurred vision / Dry mouth / Numbness or tingling / Dizziness Additional detail

    “Orally, a single dose of tyramine 400 mg has been reported to cause dry mouth, restlessness, dizziness, and headache in healthy volunteers. In a case series, consuming foods thought to contain tyramine, including cheese, was associated with headache, dizziness, memory dysfunction, blurred vision, numbness, and tingling. However, tyramine levels of the implicated foods were not determined.”

    Tyramine · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 105519. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed
    2. 101018. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
  • A fast or pounding heartbeat Additional detail

    “In a case series, consuming foods thought to contain tyramine, including cheese, was associated with panic attacks with palpitations. However, tyramine levels of the implicated foods were not determined.”

    Tyramine · Natural Medicines adverse-effect record, reported in panic disorder.

    1 source cited
    1. 101018. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
  • Anxiety or restlessness Additional detail

    Recorded for Tyramine in the same Natural Medicines adverse-effect record shown under Blurred vision / Dry mouth / Numbness or tingling / Dizziness above.

Showing the 10 most notable of 11 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Tyramine — expand a row for the licensed statement it rests on. We haven’t matched acetaminophen, dextromethorphan, doxylamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for acetaminophen, dextromethorphan, doxylamine.

From our Q&A

Questions About Tyramine or acetaminophen, dextromethorphan, doxylamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Tyramine or acetaminophen, dextromethorphan, doxylamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With acetaminophen, dextromethorphan, doxylamine

This page covers Tyramine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the acetaminophen, dextromethorphan, doxylamine page lists 106 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 8 major · 78 moderate · 20 minor.

From our pharmacist’s overview on the acetaminophen, dextromethorphan, doxylamine page

“NyQuil (acetaminophen, dextromethorphan, doxylamine) is designed to make you drowsy, and that is exactly where most of its supplement interactions live. Seventy-eight of the 106 ingredients on this list add to its sedation, and the eight rated major, alcohol and kava among them, can push a nighttime cold remedy toward serious depressio…”

Reviewed by 2 · Jul 18, 2026

Open the acetaminophen, dextromethorphan, doxylamine interaction page

One more smart check

Taking Tyramine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing Tyramine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tyramine. Even though Tyramine itself has no known interaction with acetaminophen, dextromethorphan, doxylamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tyramine and acetaminophen, dextromethorphan, doxylamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tyramine
Steady interest

#1,172 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication acetaminophen, dextromethorphan, doxylamine
Top 5%

#77 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tyramine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tyramine and acetaminophen, dextromethorphan, doxylamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tyramine

What is Tyramine?

  • Studied for effects on blood pressure
  • Discussed in relation to migraine and headache triggers
  • Of interest in food and diet science
  • Subject of research on the nervous system

Tyramine is a natural compound formed when certain proteins break down, and it is found in aged cheeses, cured meats, fermented foods, and some other items. It is not a typical health supplement and is best known for the problems it can cause—such as dangerous spikes in blood pressure—in people taking certain medications or in those who are sensitive to it. If you have been told to follow a low-tyramine diet, talk with your pharmacist or doctor before making changes.

Not a plant part; tyramine is a naturally occurring compound found in many foods · Naturally present in aged and fermented foods; not commonly sold as a stand-alone supplement

An interaction check asks whether these two react with each other — it does not ask whether Tyramine is a good idea for someone in your situation. Here is what our Tyramine record says about it on its own.

Tyramine: dosing

There is no recommended supplement dose for tyramine, because it is not meant to be taken as a health product. Instead, the main guidance is about how much tyramine to allow in the diet for people who are sensitive to it.If you have been placed on a low-tyramine diet, the goal is usually to limit aged, fermented, cured, or spoiled foods rather than to count exact milligrams. Your pharmacist or doctor can give you a food list suited to your situation.Do not try to take tyramine on purpose.

From our Tyramine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tyramine monograph & all interactions
Keep checking

Other Drugs & Tyramine

Browse every other medication we’ve checked against Tyramine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

181Major
1Moderate
171Minor
2,476No known interaction
181 Major 1 Moderate 171 Minor 2,476 No interaction
Major

181 interactions

Showing 60 of 181 major interactions — see all 181 on the Tyramine page.

Moderate

1 interaction

Minor

171 interactions

Showing 60 of 171 minor interactions — see all 171 on the Tyramine page.

No interaction 2,476 drugs checked — show the list

We also checked Tyramine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,476 medications checked with no known interaction — see the full Tyramine list.

See the full Tyramine interactions page
See every supplement checked against acetaminophen, dextromethorphan, doxylamine, ranked by severity
Evidence & sources

Tyramine References

The 15 references that drive our Tyramine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
  2. Smedema JP, Müller GJ. Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine. S Afr Med J. 2008;98(5):372-3.
  3. Gilliam LK, Palmer JP, Taborsky GJ Jr. Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humans. J Clin Endocrinol Metab. 2007;92(10):4035-8. PubMed
  4. VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9. DOI
  5. Meck JV, Martin DS, D'Aunno DS, Waters WW. Pressor response to intravenous tyramine is a marker of cardiac, but not vascular, adrenergic function. J Cardiovasc Pharmacol. 2003;41(1):126-31. PubMed
  6. Peet M, Yates RA, Carroll JA, Middlemiss DN. The interaction of tyramine with a single dose of tranylcypromine in healthy volunteers. Br J Clin Pharmacol. 1981;11(2):212-4. PubMed
  7. Del Rio B, Redruello B, Linares DM, et al. The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture. Food Chem. 2017;218:249-255. PubMed
  8. Linares DM, del Rio B, Redruello B, et al. Comparative analysis of the in vitro cytotoxicity of the dietary biogenic amines tyramine and histamine. Food Chem. 2016;197(Pt A):658-63. PubMed
  9. National Institutes of Health. Dietary Supplement Label Database. http://www.dsld.nlm.nih.gov/dsld/rptQSearch.jsp?item=tyramine&db=adsld. Accessed October 23, 2019.
  10. Rapaport MH. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: the state of the art. J Clin Psychiatry. 2007;68 Suppl 8:42-6.
  11. Colombo F, Porro T, del Rosso G, Bertalero P, Orlandi L, Libretti A. Cardiovascular responses to physical exercise and tyramine infusion in hypertensive and normotensive subjects. J Hum Hypertens. 1989;3(4):245-9.
  12. Pace DG, Reele SB, Rozik LM, Rogers-Phillips CA, Dabice JA, Givens SV. Evaluation of methods of administering tyramine to raise systolic blood pressure. Clin Pharmacol Ther. 1988;44(2):137-44. PubMed
  13. Caston JC, Eaton CL, Gheorghiu BP, Ware LL. Tyramine induced hypertensive episodes and panic attacks in hereditary deficient monoamine oxidase patients: case reports. J S C Med Assoc. 2002;98(4):187-92.
  14. European Food Safety Authority. Scientific opinion on risk based control of biogenic amine formation in fermented foods. EFSA Journal. 2011;9(10):2393. DOI
  15. Rafehi M, Faltraco F, Matthaei J, et al. Highly variable pharmacokinetics of tyramine in humans and polymorphisms in OCT1, CYP2D6, and MAO-A. Front Pharmacol. 2019 Oct 30;10:1297. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tyramine and acetaminophen, dextromethorphan, doxylamine Together: Common Questions

Is it safe to take Tyramine with acetaminophen, dextromethorphan, doxylamine?
We do not list a known interaction between Tyramine and acetaminophen, dextromethorphan, doxylamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Tyramine and acetaminophen, dextromethorphan, doxylamine combination checked?
Interactions in our licensed database are recorded against drug classes. acetaminophen, dextromethorphan, doxylamine is filed under 4 classifications, and Tyramine has documented interactions with 4 drug classes — none of acetaminophen, dextromethorphan, doxylamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tyramine interact with any other medications?
Yes. Tyramine has 353 documented drug interactions in our database — acetaminophen, dextromethorphan, doxylamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does acetaminophen, dextromethorphan, doxylamine interact with any supplements?
Yes. acetaminophen, dextromethorphan, doxylamine has documented interactions with 106 supplements in our database — Tyramine is not one of them. The acetaminophen, dextromethorphan, doxylamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tyramine monograph Uses, safety profile, and every drug interaction in one place acetaminophen, dextromethorphan, doxylamine supplement interactions Every supplement checked against acetaminophen, dextromethorphan, doxylamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About acetaminophen, dextromethorphan, doxylamine and Tyramine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.