Medication interaction hub

What Supplements Interact with Butabarbital Sodium?

Butabarbital Sodium brand names: Butisol Sodium, Sarisol #2. Every interaction below applies to the brands too.

97 Interactions 7 Major 74 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Butabarbital Sodium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Butabarbital Sodium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Butabarbital sodium (Butisol Sodium) is a barbiturate, an older sedative prescribed for sleep and anxiety, and this class of drug leaves little margin once sedation stacks, so its list of 97 interacting supplements deserves genuine respect. The dominant theme, covering 78 of the ingredients, is added nervous system depression: anything that makes you drowsy on its own can deepen a barbiturate's effects, sometimes to the point of slowed breathing. Alcohol stands out most; beer and wine both carry major ratings backed by solid human evidence, and kava sits in the same major tier.

Seven of the 97 entries rate major and 74 moderate, and most of the majors are sedation-related. The exception is activated charcoal, one of 17 ingredients that can blunt how much of an oral dose your body absorbs; keep those well separated from the medication and let your pharmacist help with the specifics.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 74 Minor 16 No known interaction 1,355

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Butabarbital Sodium: Top Interactions at a Glance

The most significant Butabarbital Sodium supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 97 interacting ingredients — plus 1,355 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Butabarbital Sodium + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Butabarbital Sodiumi

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Butabarbital Sodiumi

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Butabarbital Sodiumi

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Butabarbital Sodiumi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Butabarbital Sodiumi

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Butabarbital Sodiumi

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Butabarbital Sodium

All 1,452 ingredients in our database, ranked by severity — 97 with a Butabarbital Sodium interaction on file and 1,355 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Butabarbital Sodium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Kava with Butabarbital Sodium?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Butabarbital Sodium answer

Can you take Tarragon with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Butabarbital Sodium answer

Can you take Gamma-aminobutyric Acid (gaba) with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Full Gamma-aminobutyric Acid (gaba) + Butabarbital Sodium answer

Can you take Theacrine with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Butabarbital Sodium answer

Can you take Tianeptine with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Butabarbital Sodium answer

Can you take Tragacanth with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Butabarbital Sodium answer

Can you take Tree Turmeric with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.

Full Tree Turmeric + Butabarbital Sodium answer

Can you take Valerian with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.

Full Valerian + Butabarbital Sodium answer

Can you take Wild Lettuce with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Full Wild Lettuce + Butabarbital Sodium answer

Can you take Yin Chen with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.

Full Yin Chen + Butabarbital Sodium answer

Can you take Zizyphus with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.

Full Zizyphus + Butabarbital Sodium answer

Can you take Lavender with Butabarbital Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.

Full Lavender + Butabarbital Sodium answer

Can you take Thyroid Extract with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Butabarbital Sodium answer

Can you take Agar with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Butabarbital Sodium answer

Can you take Algin with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Butabarbital Sodium answer

Can you take Black Psyllium with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Butabarbital Sodium answer

Can you take Blond Psyllium with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Butabarbital Sodium answer

Can you take Calea Zacatechichi with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.

Full Calea Zacatechichi + Butabarbital Sodium answer

Can you take Carob with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Butabarbital Sodium answer

Can you take Karaya Gum with Butabarbital Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Butabarbital Sodium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Butabarbital Sodium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Butabarbital Sodium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Butabarbital Sodium sits in 3 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Butabarbital Sodium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Butabarbital Sodium through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Butabarbital Sodium through this category.

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Take a Supplement Product? Check the Whole Bottle Against Butabarbital Sodium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Butabarbital Sodium.

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Pharmacist Counseling Corner

Butabarbital Sodium & Supplements: Common Questions

What supplements interact with Butabarbital Sodium?
In our interaction database, 97 supplement and herbal ingredients have an interaction with Butabarbital Sodium on file — 7 rated major, 74 moderate, and 16 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Butabarbital Sodium supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Butabarbital Sodium?
That depends entirely on which supplement. The honest answer for Butabarbital Sodium is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Butisol Sodium have the same supplement interactions as Butabarbital Sodium?
Yes — Butisol Sodium, Sarisol #2 all contain Butabarbital Sodium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Butabarbital Sodium and my other medications?
This page covers Butabarbital Sodium against supplements and herbal ingredients. Checking Butabarbital Sodium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.