Drug & supplement interaction

Cnidium + Butabarbital Sodium

Butabarbital Sodium brand names: Butisol Sodium, Sarisol #2.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cnidium has a moderate interaction with Butabarbital Sodium. In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cnidium and Butabarbital Sodium

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Butabarbital Sodium

Butabarbital Sodium falls under CNS DEPRESSANTS — the group Cnidium interacts with.

In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins. Theoretically, cnidium may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Butabarbital is a barbiturate sleep and anxiety medicine, and it already does a good job of slowing down the brain and nervous system. Here's the concern with cnidium: in lab and animal studies, some of its natural coumarins (like osthole) seem to have their own calming, sleep-promoting effect. So putting the two together could, in theory, push that sedation further than you want.

If they did stack up, you might feel extra drowsy, foggy, dizzy, or unsteady, with slower breathing in larger doses. I'll be straight with you though: this is only a theoretical worry based on test-tube and animal work, not human studies. Still, because barbiturates are strong, it's worth running this past your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sun Y, Yang AWH, Lenon GB. Phytochemistry, ethnopharmacology, pharmacokinetics and toxicology of Cnidium monnieri (L.) Cusson. Int J Mol Sci. 2020;21(3):1006. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cnidium Also Interacts With Other Medications

Cnidium has 350 moderate known drug interactions in our database — the Butabarbital Sodium one above is one of them. If you take anything else, check it against the full list below.

Moderate 350 No known interaction 2,480 (incl. Butabarbital Sodium)
Taking anything else?

Check Another of Your Medications Against Cnidium

Covers the 2,830 medications we’ve checked against Cnidium. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Butabarbital Sodium

This page covers Cnidium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Butabarbital Sodium page lists 97 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 74 moderate · 16 minor.

From our pharmacist’s overview on the Butabarbital Sodium page

“Butabarbital sodium (Butisol Sodium) is a barbiturate, an older sedative prescribed for sleep and anxiety, and this class of drug leaves little margin once sedation stacks, so its list of 97 interacting supplements deserves genuine respect. The dominant theme, covering 78 of the ingredients, is added nervous system depression: anything…”

Reviewed by 2 · Jul 18, 2026

Open the Butabarbital Sodium interaction page

One more smart check

Taking Cnidium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 175 real supplement products containing Cnidium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cnidium. Your product may carry other ingredients that interact with Butabarbital Sodium too, on top of Cnidium — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cnidium and Butabarbital Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cnidium
Top half

#441 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Butabarbital Sodium
Steady interest

#2,152 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cnidium

What is Cnidium?

Cnidium
  • Skin conditions and itching
  • Erectile dysfunction and low libido
  • Eczema and dermatitis
  • Antifungal or antimicrobial washes
  • Athletic performance
  • General antioxidant support

Cnidium is the dried fruit of an Asian plant long used in traditional Chinese medicine, mostly for skin problems and sexual health. Modern human evidence for these uses is very limited, with most research coming from laboratory and animal studies. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Cnidium monograph & all interactions
Keep checking

Other Drugs & Cnidium

Browse every other medication we’ve checked against Cnidium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
350Moderate
0Minor
2,479No known interaction
350 Moderate 2,479 No interaction
Moderate

350 interactions

Showing 60 of 350 moderate interactions — see all 350 on the Cnidium page.

No interaction 2,479 drugs checked — show the list

We also checked Cnidium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,479 medications checked with no known interaction — see the full Cnidium list.

See the full Cnidium interactions page
See every supplement checked against Butabarbital Sodium, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cnidium monograph › Uses, safety, and every drug interaction in one place Butabarbital Sodium supplement interactions › Every supplement checked against Butabarbital Sodium, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cnidium and Butabarbital Sodium Together: Common Questions

Can you take Cnidium with Butabarbital Sodium?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cnidium and Butabarbital Sodium interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Butabarbital Sodium and Cnidium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.