Madder + Butabarbital Sodium
Butabarbital Sodium brand names: Butisol Sodium, Sarisol #2.
We found no known interaction between Madder and Butabarbital Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Madder and Butabarbital Sodium
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Butabarbital Sodium and Madder in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Madder at all — not against Butabarbital Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Madder safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Madder in Pregnancy & Breastfeeding
When used orally because it may be a potential menstrual stimulant and a genotoxin.
When used orally because it is a potential genotoxin. It also can cause red-colored breast milk.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Butabarbital Sodium
This page covers Madder only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Butabarbital Sodium page lists 97 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 7 major · 74 moderate · 16 minor.
From our pharmacist’s overview on the Butabarbital Sodium page
“Butabarbital sodium (Butisol Sodium) is a barbiturate, an older sedative prescribed for sleep and anxiety, and this class of drug leaves little margin once sedation stacks, so its list of 97 interacting supplements deserves genuine respect. The dominant theme, covering 78 of the ingredients, is added nervous system depression: anything…”
Reviewed by 2 · Jul 18, 2026
Taking Madder as Part of a Dietary Supplement Product? Check It for Interactions
We hold 9 real supplement products containing Madder, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Madder. Even though Madder itself has no known interaction with Butabarbital Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Madder and Butabarbital Sodium Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#792 of 1,452 supplements looked up here in the last 7 days
#2,142 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Madder reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Madder and Butabarbital Sodium records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Madder
What is Madder?
- Kidney and bladder stones
- Urinary tract complaints
- Menstrual problems
- Natural red dye for fabric
- Traditional digestive remedy
Madder is a plant whose root has long been used as a red dye and in traditional medicine, mostly for kidney and urinary problems. There is very little reliable human evidence that it works, and some of its compounds have raised concerns about possible cancer-causing effects, so it is generally not recommended for use as a supplement. Talk to your pharmacist or doctor before considering it.
Rubia tinctorum · Rubiaceae · Root · Dried root, powder, capsules, tea, extracts, and natural dye
An interaction check asks whether these two react with each other — it does not ask whether Madder is a good idea for someone in your situation. Here is what our Madder record says about it on its own.
Madder: dosing
There is no established safe or effective dose of madder for any health condition. In general, we do not recommend taking madder root internally. Its safer, well-established use is as a fabric dye rather than as a supplement.
From our Madder monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Madder
Browse every other medication we’ve checked against Madder — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Madder against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Madder list.
Madder References
The 4 references that drive our Madder monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Castelain M, Ducombs G. Contact dermatitis from madder. Contact Dermatitis 1988;19(3):228-229. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Madder and Butabarbital Sodium Together: Common Questions
Is it safe to take Madder with Butabarbital Sodium?
Does Butabarbital Sodium interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.