Drug & supplement interaction

Dimethylsulfoxide (dmso) + acetaminophen, dextromethorphan, doxylamine

acetaminophen, dextromethorphan, doxylamine brand name: NyQuil.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Dimethylsulfoxide (dmso) and acetaminophen, dextromethorphan, doxylamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Dimethylsulfoxide (dmso) and acetaminophen, dextromethorphan, doxylamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between acetaminophen, dextromethorphan, doxylamine and Dimethylsulfoxide (dmso) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dimethylsulfoxide (dmso) safety at a glance

Dimethylsulfoxide... overall Use caution Topical use can irritate skin and may carry impurities; only pharmaceutical-grade products should ever be used.

Pregnancy Avoid Safety has not been established, so it is best to avoid during pregnancy.

Breastfeeding Avoid There is not enough safety information, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining acetaminophen, dextromethorphan, doxylamine and Dimethylsulfoxide (dmso)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for acetaminophen, dextromethorphan, doxylamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. acetaminophen, dextromethorphan, doxylamine is filed under 4 classifications — including cns depressants, oral drugs. Dimethylsulfoxide (dmso) has documented interactions with 8 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), carboplatin (paraplatin) (moderate) and cholinergic drugs (moderate) — and none of acetaminophen, dextromethorphan, doxylamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dimethylsulfoxide (dmso) Does Interact With Other Medications

Dimethylsulfoxide (dmso) has 339 moderate known drug interactions in our database — acetaminophen, dextromethorphan, doxylamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 339 No known interaction 2,491 (incl. acetaminophen, dextromethorphan, doxylamine)

Taking anything else?

Check Another of Your Medications Against Dimethylsulfoxide (dmso)

Covers the 2,830 medications we’ve checked against Dimethylsulfoxide (dmso). Pick one to open its full report.

What to actually watch for

What Dimethylsulfoxide (dmso) Itself Has Been Linked To

This is not an interaction — nothing below involves acetaminophen, dextromethorphan, doxylamine. It is the side-effect record for Dimethylsulfoxide (dmso) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Dimethylsulfoxide (dmso), this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

A slow heartbeat / An irregular heartbeat / Chest pain / Raised blood pressure Worth acting on Additional detail
“Infusion of hematopoietic stem cells cryopreserved with DMSO might cause hypertension with tachycardia, bradycardia, chest tightness, and ventricular extrasystoles. Intravenously, DMSO can cause vasodilation, facial flushing, hypotension, chest pains, and sinus tachycardia.”

Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in hypertension.
6 sources cited

5695. Barker SB, Matthews PN, Philip PF, Williams G. Prospective study of intravesical dimethyl sulphoxide in the treatment of chronic inflammatory bladder disease. Br J Urol 1987;59:142-4. PubMed

5696. Fowler JE Jr. Prospective study of intravesical dimthyl sulfoxide in treatment of suspected early interstitial cystitis. Urology 1981;18:21-6.

5697. Shirley SW, Stewart BH, Mirelman S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology 1978;11:215-20. PubMed

6318. Rowley SD. Hematopoietic stem cell processing and cryopreservation. J Clin Apheresis 1992;7:132-4. PubMed

6320. Zambelli A, Poggi G, Da Prada G, et al. Clinical toxicity of cryopreserved circulation progenitor cells infusion. Anticancer Res 1998;18:4705-8.

6300. Marshall LF, Camp PE, Bowers SA. Dimethyl sulfoxide for the treatment of intracranial hypertension: a preliminary trial. Neurosurg 1984;14:659-63. DOI
Wheezing / Shortness of breath Worth acting on Additional detail
“Topically, DMSO might cause dry or sore throat, cough, dry nasal passages, dyspnea, worsening of bronchial asthma, and an influenza-like syndrome.”

Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in asthma.
6 sources cited

6303. Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. PubMed

6304. Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60. PubMed

6306. Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.

6308. Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6. PubMed

6309. Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6.

6311. Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80. PubMed
Confusion Worth acting on Additional detail
“Topically, DMSO might cause sedation, headache, dizziness, and drowsiness.

Intravenously, DMSO might cause weakness, confusion, lethargy, disorientation, agitation, dysarthria, hypoactive reflexes, decreased consciousness, and encephalopathy.

Infusion of hematopoietic stem cells cryopreserved with DMSO might cause rigors and chills.”

Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in cluster headache.
6 sources cited

6303. Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. PubMed

6304. Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60. PubMed

6306. Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.

6308. Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6. PubMed

6309. Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6.

6311. Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80. PubMed
Chills Additional detail

Recorded for Dimethylsulfoxide (dmso) in the same Natural Medicines adverse-effect record shown under Confusion above.
Flushing Additional detail

Recorded for Dimethylsulfoxide (dmso) in the same Natural Medicines adverse-effect record shown under A slow heartbeat / An irregular heartbeat / Chest pain / Raised blood pressure above.
Sore throat Additional detail

Recorded for Dimethylsulfoxide (dmso) in the same Natural Medicines adverse-effect record shown under Wheezing / Shortness of breath above.

Showing the 10 most notable of 26 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Dimethylsulfoxide (dmso) — expand a row for the licensed statement it rests on. We haven’t matched acetaminophen, dextromethorphan, doxylamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for acetaminophen, dextromethorphan, doxylamine.

Everything else you take

See Every Supplement That Interacts With acetaminophen, dextromethorphan, doxylamine

This page covers Dimethylsulfoxide (dmso) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the acetaminophen, dextromethorphan, doxylamine page lists 106 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 8 major · 78 moderate · 20 minor.

From our pharmacist’s overview on the acetaminophen, dextromethorphan, doxylamine page

“NyQuil (acetaminophen, dextromethorphan, doxylamine) is designed to make you drowsy, and that is exactly where most of its supplement interactions live. Seventy-eight of the 106 ingredients on this list add to its sedation, and the eight rated major, alcohol and kava among them, can push a nighttime cold remedy toward serious depressio…”

Reviewed by 2 · Jul 18, 2026

Open the acetaminophen, dextromethorphan, doxylamine interaction page

How much people look this up

Where Dimethylsulfoxide (dmso) and acetaminophen, dextromethorphan, doxylamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dimethylsulfoxide (dmso)

Top half

#659 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication acetaminophen, dextromethorphan, doxylamine

Top 5%

#77 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dimethylsulfoxide (dmso) reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Dimethylsulfoxide (dmso) and acetaminophen, dextromethorphan, doxylamine records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Dimethylsulfoxide (dmso)

What is Dimethylsulfoxide (dmso)?

Muscle and joint pain
Arthritis
Sprains and strains
Interstitial cystitis (bladder pain)
Skin penetration enhancer for other medicines

DMSO is a colorless liquid solvent that people apply to the skin for pain and inflammation, and it is FDA-approved (as a prescription) only for interstitial cystitis placed directly into the bladder. Most over-the-counter uses for pain and arthritis have limited or low-quality evidence, and DMSO can carry impurities or push other chemicals through your skin. Talk to your pharmacist or doctor before using it, and avoid industrial-grade products.

Industrially produced chemical compound (a byproduct of wood pulp processing) · Topical cream, gel, liquid solution; bladder instillation solution (prescription); industrial-grade and pharmaceutical-grade liquids

An interaction check asks whether these two react with each other — it does not ask whether Dimethylsulfoxide (dmso) is a good idea for someone in your situation. Here is what our Dimethylsulfoxide (dmso) record says about it on its own.

Dimethylsulfoxide (dmso): dosing

There is no single standardized over-the-counter dose of DMSO for pain or arthritis.

From our Dimethylsulfoxide (dmso) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dimethylsulfoxide (dmso) monograph & all interactions

Keep checking

Other Drugs & Dimethylsulfoxide (dmso)

Browse every other medication we’ve checked against Dimethylsulfoxide (dmso) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

339Moderate

0Minor

2,490No known interaction

339 Moderate 2,490 No interaction

Moderate

339 interactions

Showing 60 of 339 moderate interactions — see all 339 on the Dimethylsulfoxide (dmso) page.

No interaction 2,490 drugs checked — show the list

We also checked Dimethylsulfoxide (dmso) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,490 medications checked with no known interaction — see the full Dimethylsulfoxide (dmso) list.

See the full Dimethylsulfoxide (dmso) interactions page

See every supplement checked against acetaminophen, dextromethorphan, doxylamine, ranked by severity

Evidence & sources

Dimethylsulfoxide (dmso) References

The 27 references that drive our Dimethylsulfoxide (dmso) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Ludwig CU, Stoll HR, Obrist R, Obrecht JP. Prevention of cytotoxic drug induced skin ulcers with dimethyl sulfoxide (DMSO) and alpha-tocopherol. Eur J Cancer Clin Oncol 1987;23:327-9.
Barker SB, Matthews PN, Philip PF, Williams G. Prospective study of intravesical dimethyl sulphoxide in the treatment of chronic inflammatory bladder disease. Br J Urol 1987;59:142-4. PubMed
Fowler JE Jr. Prospective study of intravesical dimthyl sulfoxide in treatment of suspected early interstitial cystitis. Urology 1981;18:21-6.
Shirley SW, Stewart BH, Mirelman S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology 1978;11:215-20. PubMed
Marshall LF, Camp PE, Bowers SA. Dimethyl sulfoxide for the treatment of intracranial hypertension: a preliminary trial. Neurosurg 1984;14:659-63. DOI
Karaca M, Bilgin UY, Akar M, de la Torre JC. Dimethyl sulphoxide lowers ICP after head trauma. Eur J Clin Pharmacol 1991;40:113-4.
Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. PubMed
Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60. PubMed
Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.
Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6. PubMed
Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6.
Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80. PubMed
Wildenhoff KE, Esmann V, Ipsen J, Harving H, et al. Treatment of trigeminal and thoracic zoster with idoxuridine. Scand J Infect Dis 1981;13:257-62. PubMed
Williams HJ, Furst DE, Dahl SL, et al. Double-blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis. Arthritis Rheum 1985;28:308-14. PubMed
Takacs T, Montet JC. In vitro dissolution of cholesterol biliary stones. Gut 1995;37:157-8. PubMed
Rowley SD. Hematopoietic stem cell processing and cryopreservation. J Clin Apheresis 1992;7:132-4. PubMed
Zambelli A, Poggi G, Da Prada G, et al. Clinical toxicity of cryopreserved circulation progenitor cells infusion. Anticancer Res 1998;18:4705-8.
Wolf P, Simon M. Dimethyl sulphoxide (DMSO) induced serum hyperosmolality. Clin Biochem 1983;16:261-2. PubMed
Jacob SW, Herschler R. Pharmacology of DMSO. Cryobiology 1986;23:14-27. PubMed
Hucker HB, Ahmad PM, Miller EA, et al. Metabolism of dimethyl sulphoxide to dimethyl sulphone in the rat and man. Nature 1966;209:619-20. PubMed
Brien S, Prescott P, Lewith G. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med 2009 May 27. [Epub ahead of print]. PubMed
Shirley, H. H., Lundergan, M. K., Williams, H. J., and Spruance, S. L. Lack of ocular changes with dimethyl sulfoxide therapy of scleroderma. Pharmacotherapy 1989;9(3):165-168. PubMed
Hall MD, Telma KA, Chang KE, Lee TD, Madigan JP, Lloyd JR, Goldlust IS, Hoeschele JD, Gottesman MM. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014 Jul 15;74(14):3913-22. doi: 10.1158/00 PubMed
Clinoril (sulindac) prescribing information. Merck & Co., Inc., Whitehouse Station, NJ, 2005. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/017911s074lbl.pdf. Accessed 7/27/2020.
Visudyne (verteporfin) prescribing information. JHP Pharmaceuticals, LLC, Rochester, MI, 2016. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021119s027lbl.pdf. Accessed 7/27/2020.
Capriotti K, Capriotti JA. Dimethyl sulfoxide: history, chemistry, and clinical utility in dermatology. J Clin Aesthet Dermatol. 2012;5(9):24-6.
DOMOSO SOLUTION (90% Dimethyl Sulfoxide). Fort Dodge Animal Health, Fort Dodge, Iowa. Avaliable at: https://www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/domoso_solution_pi.pdf. Accessed 8/3/2020.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dimethylsulfoxide (dmso) and acetaminophen, dextromethorphan, doxylamine Together: Common Questions

Is it safe to take Dimethylsulfoxide (dmso) with acetaminophen, dextromethorphan, doxylamine?

We do not list a known interaction between Dimethylsulfoxide (dmso) and acetaminophen, dextromethorphan, doxylamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Dimethylsulfoxide (dmso) and acetaminophen, dextromethorphan, doxylamine combination checked?

Interactions in our licensed database are recorded against drug classes. acetaminophen, dextromethorphan, doxylamine is filed under 4 classifications, and Dimethylsulfoxide (dmso) has documented interactions with 8 drug classes — none of acetaminophen, dextromethorphan, doxylamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Dimethylsulfoxide (dmso) interact with any other medications?

Yes. Dimethylsulfoxide (dmso) has 339 documented drug interactions in our database — acetaminophen, dextromethorphan, doxylamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does acetaminophen, dextromethorphan, doxylamine interact with any supplements?

Yes. acetaminophen, dextromethorphan, doxylamine has documented interactions with 106 supplements in our database — Dimethylsulfoxide (dmso) is not one of them. The acetaminophen, dextromethorphan, doxylamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dimethylsulfoxide (dmso) monograph Uses, safety profile, and every drug interaction in one place acetaminophen, dextromethorphan, doxylamine supplement interactions Every supplement checked against acetaminophen, dextromethorphan, doxylamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 27 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.