Pygeum + ADO-Trastuzumab Emtansine
ADO-Trastuzumab Emtansine brand name: Kadcyla.
We found no known interaction between Pygeum and ADO-Trastuzumab Emtansine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Pygeum and ADO-Trastuzumab Emtansine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between ADO-Trastuzumab Emtansine and Pygeum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Pygeum at all — not against ADO-Trastuzumab Emtansine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pygeum safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With ADO-Trastuzumab Emtansine
This page covers Pygeum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the ADO-Trastuzumab Emtansine page lists 121 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).
By severity: 2 major · 87 moderate · 32 minor.
From our pharmacist’s overview on the ADO-Trastuzumab Emtansine page
“If you're taking ado-trastuzumab emtansine (Kadcyla) for HER2-positive breast cancer, treat this list as one to check carefully, not casually. Every one of the 121 flagged ingredients affects the same enzyme, CYP3A4, which your body uses to clear part of this medicine.”
Reviewed by 2 · Jul 18, 2026
Taking Pygeum as Part of a Dietary Supplement Product? Check It for Interactions
We hold 905 real supplement products containing Pygeum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pygeum. Even though Pygeum itself has no known interaction with ADO-Trastuzumab Emtansine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Pygeum and ADO-Trastuzumab Emtansine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#278 of 1,452 supplements looked up here in the last 7 days
#82 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pygeum reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Pygeum and ADO-Trastuzumab Emtansine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pygeum
What is Pygeum?
- Benign prostatic hyperplasia (BPH) symptoms
- Urinary symptoms in men
- Prostate health
- Inflammation
Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these symptoms, but the research is limited and not high quality. Talk with your doctor or pharmacist before using it, especially since urinary symptoms can have serious causes.
Prunus africana · Rosaceae · Bark · Capsules, tablets, liquid extracts
An interaction check asks whether these two react with each other — it does not ask whether Pygeum is a good idea for someone in your situation. Here is what our Pygeum record says about it on its own.
Pygeum: dosing
There is no single official or standardized dose of pygeum. Do not assume that taking more will work better, and let your healthcare provider know you are using it so they can monitor your symptoms.
From our Pygeum monograph — the full record covers uses, side effects and every documented interaction.
About Ado-trastuzumab Emtansine Injection
What Is Ado-trastuzumab Emtansine Injection Used For?
Brand name: Kadcyla
Kadcyla (ado-trastuzumab emtansine) is used on its own to treat HER2-positive metastatic breast cancer in adults who have already received trastuzumab and a taxane chemotherapy, either together or separately. It is used when cancer has come back or spread, or when the disease returned within six months of finishing earlier treatment.
Kadcyla is also used as adjuvant (after-surgery) treatment for HER2-positive early breast cancer in patients who still had remaining cancer after completing neoadjuvant (pre-surgery) treatment with a taxane and trastuzumab. Patients must be tested for HER2 overexpression or gene amplification using an FDA-authorized test before starting Kadcyla.
Most-Reported Side Effects for ADO-Trastuzumab Emtansine
From FAERS, the FDA’s public side-effect reporting system (8,277 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Pygeum
Browse every other medication we’ve checked against Pygeum — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Pygeum against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Isotretinoin ›
- Tirzepatide ›
- Warfarin Sodium ›
- Amlodipine Besylate ›
- Ibuprofen ›
- Methamphetamine ›
- Docusate ›
- Sumatriptan ›
- Tadalafil ›
- Valacyclovir ›
- Hydroxyurea ›
- Prednisone ›
- Metformin ›
- Amitriptyline ›
- Semaglutide ›
- Lisdexamfetamine ›
- Propranolol ›
- Amphetamine ›
- Amoxicillin ›
- Levothyroxine, Liothyronine ›
- Methotrexate ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Bendamustine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Dextroamphetamine ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Naproxen ›
- Quetiapine ›
- Acetaminophen, Aspirin, Caffeine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Acetaminophen, Codeine ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pygeum list.
Pygeum References
The 3 references that drive our Pygeum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Ishani A, MacDonald R, Nelson D, et al. Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis. Am J Med 2000;109:654-64.. PubMed
- Wilt T, Ishani A, Mac Donald R, et al. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev 2002;CD001044.. PubMed
- Andro M and Riffaud J. Pygeum africanum extract for the treatment of patients with benign prostatic hyperplasia: a review of 25 years of published experience. Curr Ther Res 1995;56(8):796-817. DOI
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Pygeum and ADO-Trastuzumab Emtansine Together: Common Questions
Is it safe to take Pygeum with ADO-Trastuzumab Emtansine?
Do Pygeum and ADO-Trastuzumab Emtansine have any of the same side effects?
Does ADO-Trastuzumab Emtansine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.