Drug & supplement interaction

Cesium + ADO-Trastuzumab Emtansine

ADO-Trastuzumab Emtansine brand name: Kadcyla.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cesium and ADO-Trastuzumab Emtansine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cesium and ADO-Trastuzumab Emtansine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between ADO-Trastuzumab Emtansine and Cesium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cesium safety at a glance

Cesium overall Avoid Cesium chloride can cause life-threatening heart rhythm problems and has no proven benefit.
Pregnancy Avoid Not safe; avoid during pregnancy due to serious toxicity risks.
Breastfeeding Avoid Not safe; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining ADO-Trastuzumab Emtansine and Cesium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for ADO-Trastuzumab Emtansine

Interactions in our licensed database are recorded against drug classes, not just single drug names. ADO-Trastuzumab Emtansine is filed under a single classification — cytochrome p450 3a4 (cyp3a4) substrates. Cesium has documented interactions with 3 drug classes — the most serious being qt interval-prolonging drugs (major), corticosteroids (moderate) and diuretic drugs (moderate) — and none of ADO-Trastuzumab Emtansine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cesium Does Interact With Other Medications

Cesium has 161 major, 94 moderate known drug interactions in our database — ADO-Trastuzumab Emtansine isn’t one of them. If you take anything else, check it against the full list below.

Major 161 Moderate 94 No known interaction 2,575 (incl. ADO-Trastuzumab Emtansine)
Taking anything else?

Check Another of Your Medications Against Cesium

Covers the 2,830 medications we’ve checked against Cesium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cesium and ADO-Trastuzumab Emtansine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Low potassium Worth acting on Additional detail

    Cesium

    “Orally and by injection, cesium has been associated with hypokalemia. In multiple case reports, patients presented with hypokalemia and arrhythmia that resolved after discontinuation of cesium supplementation. It is not clear whether these reports of hypokalemia were due to a direct effect of cesium on potassium channels.”

    Cesium · Natural Medicines adverse-effect record, reported in arrhythmia.

    3 sources cited
    1. 12178. Lyon AW, Mayhew WJ. Cesium toxicity: A case of self-treatment by alternate therapy gone awry. Ther Drug Monit 2003;25:114-6. PubMed
    2. 15262. Vyas H, Johnson K, Houlihan R, et al. Acquired long QT syndrome secondary to cesium chloride supplement. J Altern Complement Med 2006;12:1011-4. PubMed
    3. 16690. Pinter A, Dorian P, Newman D. Cesium-induced torsades de pointes. N Engl J Med 2002;346:383-4. PubMed

    ADO-Trastuzumab Emtansine

    Listed in the ADVERSE REACTIONS section of the FDA label for ADO-Trastuzumab Emtansine. Read the label on DailyMed ›

  • Numbness or tingling reported in 5.5% of FDA reports for ADO-Trastuzumab Emtansine Additional detail

    Cesium

    “Orally and by injection, cesium chloride has been associated with arrhythmias such as ventricular tachycardia, QT prolongation, cardiac arrest, seizures, and death. There are at least 23 reports of cardiotoxicity or death in patients taking cesium supplements.

    In one case report, a healthy 39-year-old female taking an unknown amount of cesium chloride as part of a "detoxification" program developed three episodes of…”

    Cesium · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 101651. Public Health Alert Concerning Dietary Supplements Containing Cesium Salts. FDA Dietary Supplement Products & Ingredients. February 5, 2020. Available at: https://www.fda.gov/food/dietary-supplement-products-ingredients/public-health-alert-concerning-diet
    2. 15262. Vyas H, Johnson K, Houlihan R, et al. Acquired long QT syndrome secondary to cesium chloride supplement. J Altern Complement Med 2006;12:1011-4. PubMed
    3. 12178. Lyon AW, Mayhew WJ. Cesium toxicity: A case of self-treatment by alternate therapy gone awry. Ther Drug Monit 2003;25:114-6. PubMed
    4. 16689. Cesium chloride and ventricular arrhythmias. Canadian Adverse Reaction Newsletter 2008;18:3-4.
    5. 16690. Pinter A, Dorian P, Newman D. Cesium-induced torsades de pointes. N Engl J Med 2002;346:383-4. PubMed
    6. 16691. O'Brien CE, Harik N, James LP, et al. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy 2008;28:1059-65. PubMed

    ADO-Trastuzumab Emtansine

    Listed in the ADVERSE REACTIONS section of the FDA label for ADO-Trastuzumab Emtansine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Diarrhea / Nausea reported in 8.8% of FDA reports for ADO-Trastuzumab Emtansine Additional detail

    Cesium

    “Orally, cesium can cause nausea, diarrhea, and anorexia.”

    Cesium · Natural Medicines adverse-effect record, reported in anorexia.

    1 source cited
    1. 7671. Neulieb R. Effect of oral intake of cesium chloride: a single case report. Pharmacol Biochem Behav 1984;21:15-6.

    ADO-Trastuzumab Emtansine

    Listed in the ADVERSE REACTIONS section of the FDA label for ADO-Trastuzumab Emtansine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Cesium but not commonly for ADO-Trastuzumab Emtansine: an irregular heartbeat, fainting, a fast or pounding heartbeat and reduced appetite.

Effects for ADO-Trastuzumab Emtansine come from the ADVERSE REACTIONS section of its FDA label; effects for Cesium come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 8,277 voluntary FDA FAERS reports for ADO-Trastuzumab Emtansine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What ADO-Trastuzumab Emtansine Is Prescribed For, and What Cesium Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. ADO-Trastuzumab Emtansine is a prescription medicine with approved uses on its FDA label. Cesium is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

ADO-Trastuzumab Emtansine is prescribed for: Kadcyla (ado-trastuzumab emtansine) is used on its own to treat HER2-positive metastatic breast cancer in adults who have already received trastuzumab and a taxane chemotherapy, either together or separately. It is used when cancer has come back or spread, or when the disease returned within six months of finishing earlier treatment. Kadcyla is also used as adjuvant (after-surgery) treatment for HER2-positive early breast cancer in patients who still had remaining cancer after completing neoadjuvant (pre-surgery) treatment with a taxane and trastuzumab. Patients must be tested for HER2 overexpression or gene amplification using an FDA-authorized test before starting Kadcyla.

Cesium has been studied for:

  • Cancer studied, not established Cesium has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Cesium for cancer

    Although there has been interest in using oral cesium for cancer, there is insufficient reliable information about the clinical effects of cesium for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace ADO-Trastuzumab Emtansine on your own; if you are taking Cesium for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With ADO-Trastuzumab Emtansine

This page covers Cesium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the ADO-Trastuzumab Emtansine page lists 121 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 87 moderate · 32 minor.

From our pharmacist’s overview on the ADO-Trastuzumab Emtansine page

“If you're taking ado-trastuzumab emtansine (Kadcyla) for HER2-positive breast cancer, treat this list as one to check carefully, not casually. Every one of the 121 flagged ingredients affects the same enzyme, CYP3A4, which your body uses to clear part of this medicine.”

Reviewed by 2 · Jul 18, 2026

Open the ADO-Trastuzumab Emtansine interaction page

One more smart check

Taking Cesium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 51 real supplement products containing Cesium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cesium. Even though Cesium itself has no known interaction with ADO-Trastuzumab Emtansine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cesium and ADO-Trastuzumab Emtansine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cesium
Steady interest

#935 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication ADO-Trastuzumab Emtansine
Top 25%

#513 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cesium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cesium and ADO-Trastuzumab Emtansine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cesium

What is Cesium?

  • Marketed as an alternative cancer treatment ('high pH therapy')
  • Claimed to alter tumor pH
  • General 'alkaline' health claims

Cesium chloride is a mineral salt sold as an alternative cancer therapy ('high pH therapy'), but there is no reliable scientific evidence that it treats cancer or any other disease. It can cause dangerous heart rhythm problems and even death, so it should not be used. Talk to your doctor or pharmacist before taking any supplement, and never use cesium in place of proven medical care.

Mineral element (cesium chloride salt) · Capsules, powders, liquid solutions (often as cesium chloride)

An interaction check asks whether these two react with each other — it does not ask whether Cesium is a good idea for someone in your situation. Here is what our Cesium record says about it on its own.

Cesium: dosing

There is no safe or established dose for cesium chloride, and it is not approved as a medicine. Because it can cause life-threatening harm, no dosing recommendation can be given.We strongly advise against taking cesium chloride.

From our Cesium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cesium monograph & all interactions
Medication

About Ado-trastuzumab Emtansine Injection

What Is Ado-trastuzumab Emtansine Injection Used For?

Brand name: Kadcyla

Kadcyla (ado-trastuzumab emtansine) is used on its own to treat HER2-positive metastatic breast cancer in adults who have already received trastuzumab and a taxane chemotherapy, either together or separately. It is used when cancer has come back or spread, or when the disease returned within six months of finishing earlier treatment.

Kadcyla is also used as adjuvant (after-surgery) treatment for HER2-positive early breast cancer in patients who still had remaining cancer after completing neoadjuvant (pre-surgery) treatment with a taxane and trastuzumab. Patients must be tested for HER2 overexpression or gene amplification using an FDA-authorized test before starting Kadcyla.

Most-Reported Side Effects for ADO-Trastuzumab Emtansine

From FAERS, the FDA’s public side-effect reporting system (8,277 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 781 reports
Fatigue 751 reports
Nausea 732 reports
Diarrhea 594 reports
Thrombocytopenia 468 reports
See full Ado-trastuzumab Emtansine Injection drug information
Keep checking

Other Drugs & Cesium

Browse every other medication we’ve checked against Cesium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

161Major
94Moderate
0Minor
2,574No known interaction
161 Major 94 Moderate 2,574 No interaction
Major

161 interactions

Showing 60 of 161 major interactions — see all 161 on the Cesium page.

Moderate

94 interactions

Showing 60 of 94 moderate interactions — see all 94 on the Cesium page.

No interaction 2,574 drugs checked — show the list

We also checked Cesium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,574 medications checked with no known interaction — see the full Cesium list.

See the full Cesium interactions page
See every supplement checked against ADO-Trastuzumab Emtansine, ranked by severity
Evidence & sources

Cesium References

The 9 references that drive our Cesium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sartori HE. Nutrients and cancer: an introduction to cesium therapy. Pharmacol Biochem Behav 1984;21:7-10. PubMed
  2. Neulieb R. Effect of oral intake of cesium chloride: a single case report. Pharmacol Biochem Behav 1984;21:15-6.
  3. Lyon AW, Mayhew WJ. Cesium toxicity: A case of self-treatment by alternate therapy gone awry. Ther Drug Monit 2003;25:114-6. PubMed
  4. Vyas H, Johnson K, Houlihan R, et al. Acquired long QT syndrome secondary to cesium chloride supplement. J Altern Complement Med 2006;12:1011-4. PubMed
  5. Cesium chloride and ventricular arrhythmias. Canadian Adverse Reaction Newsletter 2008;18:3-4.
  6. Pinter A, Dorian P, Newman D. Cesium-induced torsades de pointes. N Engl J Med 2002;346:383-4. PubMed
  7. O'Brien CE, Harik N, James LP, et al. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy 2008;28:1059-65. PubMed
  8. FDA alerts health care professionals of significant safety risks associated with cesium chloride. FDA: Human Drug Compounding. July 23,2018. Available at: https://www.fda.gov/drugs/human-drug-compounding/fda-alerts-health-care-professionals-significant-sa
  9. Public Health Alert Concerning Dietary Supplements Containing Cesium Salts. FDA Dietary Supplement Products & Ingredients. February 5, 2020. Available at: https://www.fda.gov/food/dietary-supplement-products-ingredients/public-health-alert-concerning-diet

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cesium and ADO-Trastuzumab Emtansine Together: Common Questions

Is it safe to take Cesium with ADO-Trastuzumab Emtansine?
We do not list a known interaction between Cesium and ADO-Trastuzumab Emtansine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cesium and ADO-Trastuzumab Emtansine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Cesium and ADO-Trastuzumab Emtansine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Cesium in each. That is a conversation for your prescriber, especially if ADO-Trastuzumab Emtansine is being adjusted to a target.
How was the Cesium and ADO-Trastuzumab Emtansine combination checked?
Interactions in our licensed database are recorded against drug classes. ADO-Trastuzumab Emtansine is filed under 1 classification, and Cesium has documented interactions with 3 drug classes — none of ADO-Trastuzumab Emtansine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cesium interact with any other medications?
Yes. Cesium has 255 documented drug interactions in our database — ADO-Trastuzumab Emtansine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does ADO-Trastuzumab Emtansine interact with any supplements?
Yes. ADO-Trastuzumab Emtansine has documented interactions with 121 supplements in our database — Cesium is not one of them. The ADO-Trastuzumab Emtansine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cesium monograph Uses, safety profile, and every drug interaction in one place Ado-trastuzumab Emtansine Injection drug information The full plain-English guide to this medication ADO-Trastuzumab Emtansine supplement interactions Every supplement checked against ADO-Trastuzumab Emtansine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About ADO-Trastuzumab Emtansine and Cesium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.