Drug & supplement interaction

Shea Butter + Brentuximab Vedotin

Brentuximab Vedotin brand name: Adcetris.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Shea Butter and Brentuximab Vedotin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Shea Butter and Brentuximab Vedotin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Brentuximab Vedotin and Shea Butter in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Shea Butter at all — not against Brentuximab Vedotin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Shea Butter safety at a glance

Shea Butter overall Generally safe Topical shea butter is generally well tolerated by most people.
Pregnancy Likely Safe When used in amounts commonly found in foods. Shea butter has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information a... Read the full pregnancy detail
Breastfeeding Likely Safe When used in amounts commonly found in foods. Shea butter has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information a... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Brentuximab Vedotin and Shea Butter? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Brentuximab Vedotin’s Own FDA Label Lists

This is not an interaction — none of it involves Shea Butter. These are the most notable effects listed in the ADVERSE REACTIONS section of Brentuximab Vedotin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • A low white blood cell count Worth acting on mentioned in 13.2% of FDA reports for Brentuximab Vedotin
  • High blood sugar Worth acting on
  • Anemia Worth acting on mentioned in 3.9% of FDA reports for Brentuximab Vedotin
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • A severe allergic reaction Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • Fever mentioned in 14.1% of FDA reports for Brentuximab Vedotin
  • Numbness or tingling mentioned in 7.0% of FDA reports for Brentuximab Vedotin

Showing the 10 most notable of 21 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Brentuximab Vedotin. Read the label on DailyMed › Where a percentage is shown, it is the share of 10,190 voluntary FDA FAERS reports for Brentuximab Vedotin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Shea Butter’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Shea Butter side to compare — that is a limit of the record, not a statement that Shea Butter has no side effects.

Special populations

Shea Butter in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used in amounts commonly found in foods. Shea butter has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information available about the safety of shea butter when used in medicinal amounts during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Brentuximab Vedotin

This page covers Shea Butter only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Brentuximab Vedotin page lists 121 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 87 moderate · 32 minor.

From our pharmacist’s overview on the Brentuximab Vedotin page

“Every entry on this page traces back to a single enzyme. Brentuximab vedotin (Adcetris), an IV treatment for Hodgkin lymphoma and certain other lymphomas, carries a chemotherapy payload the body clears through CYP3A4, and I would treat this list with real care.”

Reviewed by 2 · Jul 18, 2026

Open the Brentuximab Vedotin interaction page

How much people look this up

Where Shea Butter and Brentuximab Vedotin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Shea Butter
Steady interest

#1,399 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Brentuximab Vedotin
Steady interest

#1,806 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Shea Butter reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Shea Butter and Brentuximab Vedotin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Shea Butter

What is Shea Butter?

  • Dry skin and moisturizing
  • Soothing minor skin irritation
  • Lip and cuticle care
  • Hair and scalp conditioning
  • Reducing the look of stretch marks or scars
  • Massage and cosmetic use

Shea butter is a plant fat from the African shea tree that is widely used as a skin and hair moisturizer. It is generally considered safe for most people when applied to the skin, but most of its beauty and health claims have only limited scientific proof. It is meant for external use, not for swallowing as a supplement.

Vitellaria paradoxa · Sapotaceae · Fat extracted from the nut (seed kernel) · Raw (unrefined) butter, refined butter, lotions, creams, balms, soaps, lip balms

An interaction check asks whether these two react with each other — it does not ask whether Shea Butter is a good idea for someone in your situation. Here is what our Shea Butter record says about it on its own.

Shea Butter: dosing

There is no standardized dose for shea butter because it is used as a topical cosmetic, not a measured medicine. Most people simply apply a small amount to the skin or hair as needed and rub it in.Follow the directions on the product label, and start with a small amount to see how your skin responds.

From our Shea Butter monograph — the full record covers uses, side effects and every documented interaction.

Read the full Shea Butter monograph & all interactions
Medication

About Brentuximab Vedotin Injection

What Is Brentuximab Vedotin Injection Used For?

Brand name: Adcetris

Adcetris (brentuximab vedotin) is used to treat classical Hodgkin lymphoma (cHL) in adults — including newly diagnosed advanced-stage disease, as consolidation therapy after a stem cell transplant, and in relapsed or refractory cases. It is also approved for pediatric patients aged 2 and older with previously untreated high-risk classical Hodgkin lymphoma, given in combination with chemotherapy.

Adcetris is also used for several T-cell lymphomas — including systemic anaplastic large cell lymphoma (sALCL), peripheral T-cell lymphomas (PTCL), primary cutaneous anaplastic large cell lymphoma (pcALCL), and CD30-expressing mycosis fungoides (MF). Additionally, Adcetris is used in combination with lenalidomide and a rituximab product for adults with relapsed or refractory large B-cell lymphoma (LBCL) who are not candidates for a stem cell transplant or CAR T-cell therapy.

Most-Reported Side Effects for Brentuximab Vedotin

From FAERS, the FDA’s public side-effect reporting system (10,190 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Febrile neutropenia 758 reports
Neuropathy peripheral 711 reports
Fever 682 reports
Neutropenia 586 reports
Hodgkin^s disease 459 reports
See full Brentuximab Vedotin Injection drug information
Keep checking

Other Drugs & Shea Butter

Browse every other medication we’ve checked against Shea Butter — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Shea Butter against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Shea Butter list.

See the full Shea Butter interactions page
See every supplement checked against Brentuximab Vedotin, ranked by severity
Evidence & sources

Shea Butter References

The 5 references that drive our Shea Butter monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tella, A. Preliminary studies on nasal decongestant activity from the seed of the shea butter tree, Butyrospermum parkii. Br J Clin Pharmacol 1979;7(5):495-497. PubMed
  2. Title 21 - Food and Drugs. Part 184. Direct food substances affirmed as generally recognized as safe. Subpart B - Listings of specific substances affirmed as GRAS. Section 184.1702 - Sheanut oil. Available at: http://www.gpo.gov/fdsys/granule/CFR-2000-tit
  3. Hon KL, Tsang YC, Pong NH, et al. Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema. Hong Kong Med J. 2015;21(5):417-25. PubMed
  4. Jirabundansuk P, Ophaswongse S, Udompataikul M. Comparative trial of moisturizer containing spent grain wax, Butyrospermum parkii extract, Argania spinosa kernel oil vs. 1% hydrocortisone cream in the treatment of childhood atopic dermatitis. J Med Assoc
  5. Kofi Amegah A, Brahuah E, Stranges S. Cooking with shea butter is associated with lower blood pressure in the Ghanaian population. Int J Vitam Nutr Res 2019:1-11. [Epub ahead of print] PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Shea Butter and Brentuximab Vedotin Together: Common Questions

Is it safe to take Shea Butter with Brentuximab Vedotin?
We do not list a known interaction between Shea Butter and Brentuximab Vedotin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Brentuximab Vedotin interact with any supplements?
Yes. Brentuximab Vedotin has documented interactions with 121 supplements in our database — Shea Butter is not one of them. The Brentuximab Vedotin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Shea Butter monograph Uses, safety profile, and every drug interaction in one place Brentuximab Vedotin Injection drug information The full plain-English guide to this medication Brentuximab Vedotin supplement interactions Every supplement checked against Brentuximab Vedotin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Brentuximab Vedotin and Shea Butter?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.