Drug & supplement interaction

Shea Butter + Bupropion

Bupropion brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Shea Butter and Bupropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Shea Butter and Bupropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bupropion and Shea Butter in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Shea Butter at all — not against Bupropion, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Shea Butter safety at a glance

Shea Butter overall Generally safe Topical shea butter is generally well tolerated by most people.
Pregnancy Likely Safe When used in amounts commonly found in foods. Shea butter has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information a... Read the full pregnancy detail
Breastfeeding Likely Safe When used in amounts commonly found in foods. Shea butter has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information a... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bupropion and Shea Butter? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Bupropion’s Own FDA Label Lists

This is not an interaction — none of it involves Shea Butter. These are the most notable effects listed in the ADVERSE REACTIONS section of Bupropion’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Thoughts of self-harm Worth acting on
  • Trouble swallowing Worth acting on
  • Hallucinations Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • Raised blood pressure Worth acting on
  • Hives Worth acting on

Showing the 10 most notable of 43 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Bupropion. Read the label on DailyMed › Where a percentage is shown, it is the share of 152,137 voluntary FDA FAERS reports for Bupropion that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Shea Butter’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Shea Butter side to compare — that is a limit of the record, not a statement that Shea Butter has no side effects.

Special populations

Shea Butter in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used in amounts commonly found in foods. Shea butter has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information available about the safety of shea butter when used in medicinal amounts during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Shea Butter or Bupropion

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Shea Butter or Bupropion, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bupropion

This page covers Shea Butter only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 33 moderate · 12 minor.

From our pharmacist’s overview on the Bupropion page

“Bupropion (Wellbutrin, Zyban) deserves genuine care around supplements, and the entry to understand first is activated charcoal, the only major-rated interaction on this list. Charcoal and similar bulk products can soak up the drug in the gut and blunt its effect, so space them well apart from your dose.”

Reviewed by 2 · Jul 18, 2026

Open the Bupropion interaction page

How much people look this up

Where Shea Butter and Bupropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Shea Butter
Top half

#569 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bupropion
Top 1%

#23 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Shea Butter reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Shea Butter and Bupropion records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Shea Butter

What is Shea Butter?

  • Dry skin and moisturizing
  • Soothing minor skin irritation
  • Lip and cuticle care
  • Hair and scalp conditioning
  • Reducing the look of stretch marks or scars
  • Massage and cosmetic use

Shea butter is a plant fat from the African shea tree that is widely used as a skin and hair moisturizer. It is generally considered safe for most people when applied to the skin, but most of its beauty and health claims have only limited scientific proof. It is meant for external use, not for swallowing as a supplement.

Vitellaria paradoxa · Sapotaceae · Fat extracted from the nut (seed kernel) · Raw (unrefined) butter, refined butter, lotions, creams, balms, soaps, lip balms

An interaction check asks whether these two react with each other — it does not ask whether Shea Butter is a good idea for someone in your situation. Here is what our Shea Butter record says about it on its own.

Shea Butter: dosing

There is no standardized dose for shea butter because it is used as a topical cosmetic, not a measured medicine. Most people simply apply a small amount to the skin or hair as needed and rub it in.Follow the directions on the product label, and start with a small amount to see how your skin responds.

From our Shea Butter monograph — the full record covers uses, side effects and every documented interaction.

Read the full Shea Butter monograph & all interactions
Medication

About Bupropion

What Is Bupropion Used For?

Brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, Forfivo XL

Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter.

Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD. Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.

Most-Reported Side Effects for Bupropion

From FAERS, the FDA’s public side-effect reporting system (152,137 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 11,909 reports
Fatigue 10,076 reports
Headache 10,053 reports
Depression 8,639 reports
Dizziness 7,786 reports
See full Bupropion drug information
Keep checking

Other Drugs & Shea Butter

Browse every other medication we’ve checked against Shea Butter — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Shea Butter against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Shea Butter list.

See the full Shea Butter interactions page
See every supplement checked against Bupropion, ranked by severity
Evidence & sources

Shea Butter References

The 5 references that drive our Shea Butter monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tella, A. Preliminary studies on nasal decongestant activity from the seed of the shea butter tree, Butyrospermum parkii. Br J Clin Pharmacol 1979;7(5):495-497. PubMed
  2. Title 21 - Food and Drugs. Part 184. Direct food substances affirmed as generally recognized as safe. Subpart B - Listings of specific substances affirmed as GRAS. Section 184.1702 - Sheanut oil. Available at: http://www.gpo.gov/fdsys/granule/CFR-2000-tit
  3. Hon KL, Tsang YC, Pong NH, et al. Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema. Hong Kong Med J. 2015;21(5):417-25. PubMed
  4. Jirabundansuk P, Ophaswongse S, Udompataikul M. Comparative trial of moisturizer containing spent grain wax, Butyrospermum parkii extract, Argania spinosa kernel oil vs. 1% hydrocortisone cream in the treatment of childhood atopic dermatitis. J Med Assoc
  5. Kofi Amegah A, Brahuah E, Stranges S. Cooking with shea butter is associated with lower blood pressure in the Ghanaian population. Int J Vitam Nutr Res 2019:1-11. [Epub ahead of print] PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Shea Butter and Bupropion Together: Common Questions

Is it safe to take Shea Butter with Bupropion?
We do not list a known interaction between Shea Butter and Bupropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Bupropion interact with any supplements?
Yes. Bupropion has documented interactions with 46 supplements in our database — Shea Butter is not one of them. The Bupropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Shea Butter monograph Uses, safety profile, and every drug interaction in one place Bupropion drug information The full plain-English guide to this medication Bupropion supplement interactions Every supplement checked against Bupropion, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bupropion and Shea Butter?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.