Drug & supplement interaction

Jimson Weed + Pretomanid

Pretomanid brand name: Pretomanid.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Jimson Weed and Pretomanid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pretomanid states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Jimson Weed and Pretomanid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pretomanid and Jimson Weed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jimson Weed safety at a glance

Jimson Weed overall Avoid Jimson Weed is toxic and can cause life-threatening poisoning even at small doses.
Pregnancy Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pretomanid and Jimson Weed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pretomanid

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pretomanid is filed under 5 classifications — including immunosuppressants, qt interval-prolonging drugs, antibiotic drugs. Jimson Weed has documented interactions with 1 drug class — the most serious being anticholinergic drugs (moderate) — and none of Pretomanid’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jimson Weed Does Interact With Other Medications

Jimson Weed has 195 moderate known drug interactions in our database — Pretomanid isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Jimson Weed

Covers the 2,830 medications we’ve checked against Jimson Weed. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jimson Weed and Pretomanid May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on reported in 5.3% of FDA reports for Pretomanid Additional detail

    Jimson Weed

    “Orally, jimson weed can cause anticholinergic side effects such as hypertension, tachycardia, and arrhythmia.”

    Jimson Weed · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 57099. Matsuda, K., Morinaga, M., Okamoto, M., Miyazaki, S., Isimaru, T., Suzuki, K., and Tohyama, K. [Toxicological analysis of a case of Datura stramonium poisoning]. Rinsho Byori 2006;54(10):1003-1007.
    2. 57156. Tiongson, J. and Salen, P. Mass ingestion of Jimson Weed by eleven teenagers. Del.Med.J 1998;70(11):471-476.
    3. 57067. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
    4. 57103. Rwiza, H. T. Jimson weed food poisoning. An epidemic at Usangi rural government hospital. Trop.Geogr.Med. 1991;43(1-2):85-90.
    5. 57151. Dewitt, M. S., Swain, R., and Gibson, L. B., Jr. The dangers of jimson weed and its abuse by teenagers in the Kanawha Valley of West Virginia. W.V.Med J 1997;93(4):182-185.
    6. 57152. Amlo, H., Haugeng, K. L., Wickstrom, E., Koss, A., Husebye, T., and Jacobsen, D. [Poisoning with Jimson weed. Five cases treated with physostigmine]. Tidsskr.Nor Laegeforen. 8-10-1997;117(18):2610-2612.

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Seizures Worth acting on Additional detail

    Jimson Weed

    “Orally, jimson weed can block muscarinic cholinergic neurons and cause anticholinergic side effects. Larger amounts of jimson weed intake can also lead to toxicity and anticholinergic syndrome. Central anticholinergic symptoms, which are dose-dependent, include muscle tremor and rigidity, leg cramps, hallucinations, slurred speech, psychosis, agitated delirium, seizures, coma, cardiovascular collapse, or respiratory…”

    Jimson Weed · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 636. Hassell LH, MacMillan MW. Acute anticholinergic syndrome following ingestion of Angel's trumpet tea. Hawaii Med J 1995;54:669-70.
    2. 57067. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
    3. 57075. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed
    4. 57077. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
    5. 57078. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed
    6. 57084. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed

    “Orally, jimson weed can cause anticholinergic side effects such as memory loss, attention impairment, confusion, hallucinations, slurred speech, psychosis, agitated delirium, seizures, and coma.”

    Jimson Weed · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 57067. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
    2. 57075. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed
    3. 57077. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
    4. 57078. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed
    5. 57084. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed
    6. 57085. Parissis, D., Mellidis, C., Boutis, A., Apostolidis, K., Ignatiadis, M., Kiosses, V., and Milonas, I. Neurological findings in a case of coma secondary to Datura stramonium poisoning. Eur J Neurol. 2003;10(6):745-746.

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid. Read the label on DailyMed ›

  • A low platelet count Worth acting on Additional detail

    Jimson Weed

    “Orally, jimson weed has been reported to cause thrombocytopenia in one patient.”

    Jimson Weed · Natural Medicines adverse-effect record, reported in thrombocytopenia.

    1 source cited
    1. 109502. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid. Read the label on DailyMed ›

  • Raised blood pressure Worth acting on Additional detail

    Jimson Weed

    Recorded for Jimson Weed in the same Natural Medicines adverse-effect record shown under An irregular heartbeat above.

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Jimson Weed

    “Orally, jimson weed can cause hepatotoxic events, including fulminant hepatitis.”

    Jimson Weed · Natural Medicines adverse-effect record, reported in hepatitis.

    1 source cited
    1. 57091. Ertekin, V., Selimoglu, M. A., and Altinkaynak, S. A combination of unusual presentations of Datura stramonium intoxication in a child: rhabdomyolysis and fulminant hepatitius. J Emerg.Med. 2005;28(2):227-228. PubMed

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid. Read the label on DailyMed ›

  • Dry skin Additional detail

    Jimson Weed

    “Orally, jimson weed is unsafe.

    Most Common Adverse Effects:

    Orally: Anticholinergic effects, such as abdominal pain, altered mental status, dry eyes, dry mouth, dry skin, nausea, tachycardia, urinary retention, and vomiting.

    Serious Adverse Effects (Rare):

    Orally: Anticholinergic toxicity, death.”

    Jimson Weed · Natural Medicines adverse-effect record, reported in dry eye.

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid. Read the label on DailyMed ›

  • Blurred vision Additional detail

    Jimson Weed

    Recorded for Jimson Weed in the same Natural Medicines adverse-effect record shown under Seizures above.

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid. Read the label on DailyMed ›

  • Stomach pain / Nausea / Vomiting reported in 6.2% of FDA reports for Pretomanid Additional detail

    Jimson Weed

    “Orally, jimson weed can cause anticholinergic side effects such as abdominal pain, nausea and vomiting, decreased bowel sounds, and difficulty swallowing (13,18,5623,109502,113142).”

    Jimson Weed · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    5 sources cited
    1. 13. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 5623. Anon. Jimson weed poisoning- Texas, New York, and California, 1994. MMWR Morb Mortal Wkly Rep 1995;44:41-4.
    4. 109502. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
    5. 113142. Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604. PubMed

    Pretomanid

    Listed in the ADVERSE REACTIONS section of the FDA label for Pretomanid, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Jimson Weed but not commonly for Pretomanid: trouble swallowing, confusion, trouble passing urine and hallucinations.

Effects for Pretomanid come from the ADVERSE REACTIONS section of its FDA label; effects for Jimson Weed come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 647 voluntary FDA FAERS reports for Pretomanid that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Jimson Weed in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Pretomanid Products Have a Food Rule — Jimson Weed Should Not Break It

At least one FDA label for a product containing Pretomanid says to take it with food. If you take Jimson Weed on an empty stomach out of habit, keep them separate — and take Pretomanid with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pretomanid products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Recommended Dosage Pretomanid Tablets must be administered in combination with bedaquiline and linezolid with food [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Pretomanid — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Pretomanid

This page covers Jimson Weed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pretomanid page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 10 major · 122 moderate · 11 minor.

From our pharmacist’s overview on the Pretomanid page

“Pretomanid is reserved for highly drug-resistant tuberculosis, and it can stress the liver and lengthen the heart's QT interval, so the supplements on this page deserve genuine care. Ten of the 143 ingredients on file carry a major rating, and nearly all of those either compound the liver risk (alcohol in beer or wine is the plainest e…”

Reviewed by 2 · Jul 18, 2026

Open the Pretomanid interaction page

One more smart check

Taking Jimson Weed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Jimson Weed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jimson Weed. Even though Jimson Weed itself has no known interaction with Pretomanid, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jimson Weed and Pretomanid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jimson Weed
Steady interest

#1,077 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pretomanid
Steady interest

#2,146 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jimson Weed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Jimson Weed and Pretomanid records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jimson Weed

What is Jimson Weed?

  • Asthma and breathing problems (historical/folk use)
  • Pain relief
  • Recreational hallucinogen (highly dangerous misuse)
  • Muscle spasms
  • Skin conditions (traditional topical use)

Jimson Weed is a highly poisonous plant that contains powerful nerve-affecting compounds, and even small amounts can cause severe poisoning, hallucinations, or death. It is not a safe supplement, and there is no reliable evidence supporting its use for any health condition. Do not use Jimson Weed in any form.

Datura stramonium · Solanaceae · Leaves, seeds, flowers, and roots · Dried plant material, smoked preparations, teas, and folk extracts (none are recommended for self-use)

An interaction check asks whether these two react with each other — it does not ask whether Jimson Weed is a good idea for someone in your situation. Here is what our Jimson Weed record says about it on its own.

Jimson Weed: dosing

There is no safe or established dose of Jimson Weed. The amount of toxic alkaloids varies widely from plant to plant, season to season, and even between different parts of the same plant, so there is no way to take a predictable amount.Because of this, no responsible pharmacist or doctor recommends using it.

From our Jimson Weed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jimson Weed monograph & all interactions
Medication

About Pretomanid

What Is Pretomanid Used For?

Brand name: Pretomanid

Pretomanid Tablet is used only as part of a three-drug regimen — together with bedaquiline and linezolid — to treat adults with pulmonary (lung) tuberculosis that is resistant to multiple antibiotics, including isoniazid, rifamycins, a fluoroquinolone, and a second-line injectable TB drug. It is also used for adults whose TB is resistant to isoniazid and rifampin and who cannot tolerate or are not responding to standard TB therapy.

Pretomanid Tablets are not for drug-sensitive TB, latent (inactive) TB infection, TB outside the lungs, or TB that responds to standard treatment. They should only be used in combination with bedaquiline and linezolid — safety and effectiveness with other drug combinations have not been established.

See full Pretomanid drug information
Keep checking

Other Drugs & Jimson Weed

Browse every other medication we’ve checked against Jimson Weed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
195Moderate
0Minor
2,634No known interaction
Moderate

195 interactions

Showing 60 of 195 moderate interactions — see all 195 on the Jimson Weed page.

No interaction 2,634 drugs checked — show the list
Evidence & sources

Jimson Weed References

The 43 references that drive our Jimson Weed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Hassell LH, MacMillan MW. Acute anticholinergic syndrome following ingestion of Angel's trumpet tea. Hawaii Med J 1995;54:669-70.
  6. Urich RW, Bowerman DL, Levisky JA, Pflug JL. Datura stramonium: a fatal poisoning. J Forensic Sci 1982;27:948-54.
  7. Anon. Jimson weed poisoning- Texas, New York, and California, 1994. MMWR Morb Mortal Wkly Rep 1995;44:41-4.
  8. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
  9. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed
  10. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
  11. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed
  12. Sasaki, T., Yamazaki, K., Yamori, T., and Endo, T. Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin. Br.J Cancer 10-7-2002;87(8):918-923. PubMed
  13. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed
  14. Parissis, D., Mellidis, C., Boutis, A., Apostolidis, K., Ignatiadis, M., Kiosses, V., and Milonas, I. Neurological findings in a case of coma secondary to Datura stramonium poisoning. Eur J Neurol. 2003;10(6):745-746.
  15. Boumba, V. A., Mitselou, A., and Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Vet.Hum.Toxicol. 2004;46(2):81-82.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jimson Weed and Pretomanid Together: Common Questions

Is it safe to take Jimson Weed with Pretomanid?
We do not list a known interaction between Jimson Weed and Pretomanid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jimson Weed and Pretomanid have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Jimson Weed and Pretomanid at the same time of day?
At least one FDA label for a product containing Pretomanid says to take it with food. If you take Jimson Weed on an empty stomach out of habit, keep them separate and take Pretomanid with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Pretomanid products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Jimson Weed and Pretomanid combination checked?
Interactions in our licensed database are recorded against drug classes. Pretomanid is filed under 5 classifications, and Jimson Weed has documented interactions with 1 drug class — none of Pretomanid's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jimson Weed interact with any other medications?
Yes. Jimson Weed has 195 documented drug interactions in our database — Pretomanid is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pretomanid interact with any supplements?
Yes. Pretomanid has documented interactions with 143 supplements in our database — Jimson Weed is not one of them. The Pretomanid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pretomanid and Jimson Weed?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.