Drug & supplement interaction

Androsterone + Alpha-1 Proteinase Inhibitor

Alpha-1 Proteinase Inhibitor brand name: Aralast.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Androsterone and Alpha-1 Proteinase Inhibitor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Androsterone and Alpha-1 Proteinase Inhibitor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alpha-1 Proteinase Inhibitor and Androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androsterone safety at a glance

Androsterone overall Avoid It is a controlled anabolic-androgenic steroid that is illegal to sell as a dietary supplement in the U.S.
Pregnancy Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alpha-1 Proteinase Inhibitor and Androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Androsterone Does Interact With Other Medications

Androsterone has 9 minor known drug interactions in our database — Alpha-1 Proteinase Inhibitor isn’t one of them. If you take anything else, check it against the full list below.

Minor 9 No known interaction 2,821 (incl. Alpha-1 Proteinase Inhibitor)
Taking anything else?

Check Another of Your Medications Against Androsterone

Covers the 2,830 medications we’ve checked against Androsterone. Pick one to open its full report.

What to actually watch for

What Androsterone Itself Has Been Linked To

This is not an interaction — nothing below involves Alpha-1 Proteinase Inhibitor. It is the side-effect record for Androsterone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Androsterone, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    “Orally, androsterone is possibly unsafe. As an anabolic androgenic steroid, there is concern that it might cause serious side effects including heart disease and liver injury.”

    Androsterone · Natural Medicines adverse-effect record, reported in cardiovascular disease (cvd).

Everything above comes from the Natural Medicines adverse-effect record for Androsterone — expand a row for the licensed statement it rests on. We haven’t matched Alpha-1 Proteinase Inhibitor to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Alpha-1 Proteinase Inhibitor.

Special populations

Androsterone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

One more smart check

Taking Androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing Androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androsterone. Even though Androsterone itself has no known interaction with Alpha-1 Proteinase Inhibitor, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Androsterone and Alpha-1 Proteinase Inhibitor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androsterone
Steady interest

#1,241 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alpha-1 Proteinase Inhibitor
Top 25%

#493 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Androsterone and Alpha-1 Proteinase Inhibitor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androsterone

What is Androsterone?

Androsterone
  • Muscle building and athletic performance
  • Boosting testosterone or androgen levels
  • Supporting libido
  • Bodybuilding 'prohormone' stacks

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements under the DASCA law. There is no good evidence that taking it is safe or effective, and it carries the same hormone-related risks as other anabolic steroids. Avoid products that contain it, and talk to a pharmacist or doctor about safer, legal options.

Not applicable (a steroid hormone, not a plant) · Historically sold as oral capsules, tablets, and sublingual products in 'prohormone' supplements (now banned in the U.S.)

An interaction check asks whether these two react with each other — it does not ask whether Androsterone is a good idea for someone in your situation. Here is what our Androsterone record says about it on its own.

Androsterone: dosing

There is no established or recommended safe dose of androsterone as a supplement, and it is illegal to sell in U.S. dietary supplements. We do not provide dosing for it.If you see a product that lists androsterone or one of its alternate names on the label, treat it as a banned anabolic steroid rather than a normal supplement.

From our Androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androsterone monograph & all interactions
Keep checking

Other Drugs & Androsterone

Browse every other medication we’ve checked against Androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
9Minor
2,820No known interaction
9 Minor 2,820 No interaction
Minor

9 interactions

No interaction 2,820 drugs checked — show the list

We also checked Androsterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,820 medications checked with no known interaction — see the full Androsterone list.

See the full Androsterone interactions page
See every supplement checked against Alpha-1 Proteinase Inhibitor, ranked by severity
Evidence & sources

Androsterone References

The 1 references that drive our Androsterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androsterone and Alpha-1 Proteinase Inhibitor Together: Common Questions

Is it safe to take Androsterone with Alpha-1 Proteinase Inhibitor?
We do not list a known interaction between Androsterone and Alpha-1 Proteinase Inhibitor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Androsterone interact with any other medications?
Yes. Androsterone has 9 documented drug interactions in our database — Alpha-1 Proteinase Inhibitor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Androsterone monograph Uses, safety profile, and every drug interaction in one place Alpha-1 Proteinase Inhibitor supplement interactions Every supplement checked against Alpha-1 Proteinase Inhibitor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alpha-1 Proteinase Inhibitor and Androsterone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.