Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Metha-Quad Extreme Ingredients & Drug Interactions

by Blackstone Labs

Metha-Quad Extreme label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Metha-Quad Extreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Metha-Quad Extreme is a dietary supplement by Blackstone Labs with 4 active ingredients. Its ingredients are commonly taken for muscle building and athletic performance, boosting testosterone or androgen levels, supporting libido.Based on those ingredients, 13 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androsterone, 1-Androstene-3Beta-Ol,17-One, Androsta-3,5-Diene-7,17-Dione. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Metha-Quad Extreme by Blackstone Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Metha-Quad Extreme by Blackstone Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Metha-Quad Extreme by Blackstone Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Metha-Quad Extreme contains 4 active ingredients, all androgenic compounds (male hormone precursors or analogs): androsterone, 1-androstene-3beta-ol,17-one, 4-androstene-3beta-ol,17-one, and androsta-3,5-diene-7,17-dione. The product also includes several inactive ingredients—microcrystalline cellulose, phosphatidylcholine, hydroxypropyl-beta-cyclodextrin, phytosterol, stearic acid, magnesium stearate, starch, titanium dioxide, silica, and food colorants.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Muscle building and athletic performance support.
  • We looked for evidence on: Athletic performance, Muscle strength, Exercise-induced muscle damage, Body composition, Lean mass gain, Training recovery.
  • The closest evidence on file: 1-androsterone is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Androsterone is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength, Exercise-induced muscle damage.
  • Also on file: Arimistane is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.

The evidence we hold doesn't establish that any ingredient in this product works reliably. Androsterone is rated insufficient evidence for fatigue, sexual dysfunction, obesity, age-related testosterone deficiency, and epilepsy.

The other three ingredients are rated insufficient evidence for athletic performance, muscle strength, erectile dysfunction, sexual arousal, and obesity. In short, there's no solid proof these compounds deliver the effects they're marketed for.

The evidence, ingredient by ingredient Androsterone 1-androsterone Arimistane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This product carries serious safety concerns. Androsterone is a controlled anabolic-androgenic steroid that is illegal to sell as a dietary supplement in the U.S., and the data we hold indicates it's possibly unsafe—there's concern it could cause heart disease and liver injury.

The other three ingredients are hormone-altering compounds with little safety testing. 1-Androstene-3beta-ol,17-one and 4-androstene-3beta-ol,17-one have been linked to harmful changes in cholesterol levels (LDL up about 29 mg/dL, HDL down about 19 mg/dL after 4 weeks) and kidney function markers suggesting early kidney impairment.

Androsta-3,5-diene-7,17-dione is a hormone-altering drug with little safety data. Regulators warn against aromatase-inhibitor supplements.

None of these compounds should be used in pregnancy or while breastfeeding due to serious risks to a developing or nursing infant.

Side effects, ingredient by ingredient Androsterone 1-androsterone Arimistane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — 1-androsterone, Androsterone, Arimistane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 13 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take testosterone or any other androgenic hormones (Moderate-severity interaction risk). Also clear it beforehand if you take aromatase-inhibitor medications like letrozole or anastrozole (Moderate-severity interaction risk).

The product carries Minor-severity interaction risk with other androgens as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a potent hormonal product with documented interactions, limited safety testing, and no reliable evidence it works for its claimed purposes. If you take testosterone, other hormonal medications, or aromatase inhibitors, do not use this product without talking to your doctor or pharmacist first.

Even if you don't take those drugs, the safety profile here is concerning—have a detailed conversation with your own healthcare provider before considering it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Metha-Quad Extreme, straight from the product label.

Brand Blackstone Labs
Barcode (UPC) 650348782474
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Jul 24, 2019
DSLD ID 204774
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Metha-Quad Extreme by Blackstone Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
650348782474
IngredientAmount% DV
Androsterone150 mg--
1-Androstene-3Beta-Ol,17-One50 mg--
4-Androstene-3Beta-Ol,17-One50 mg--
Androsta-3,5-Diene-7,17-Dione50 mg--

Other ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C #40, FD&C Yellow #6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Keep out of reach of children. This product should not be taken by individuals under 18 years of age.

Consult a licensed health professional before taking this product. This product is not intended as a solo source of nutrition and should be consumed in conjunction with an appropriate physical training or exercise program.

You should not take this product if you have any current or pre-existing medical conditions, or if you are pregnant or nursing. Do not take this product if you currently taking any prescription or over-the-counter medications.

Do not exceed recommended serving as it could result in serious adverse health effects.

Allergen warning: Manufactured on shared equipment that also processes eggs, wheat, & soy (lecithin).

Do not exceed 2 tablets daily.

General Statements

Pro-anabolic Ultimate mass stack

4-in-1 Pro-anabolic

Visit our website for additional guidance.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 tablet within 1 hour of training.

Storage

Keep in a cool, dry, place away from light.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Metha-Quad Extreme by Blackstone Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Metha-Quad Extreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Metha-Quad Extreme by Blackstone Labs

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Androsterone

Interacts with
9 drugs
150 mg per serving

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are...

Androsterone monograph & interactions

1-Androstene-3Beta-Ol,17-One

Interacts with
8 drugs
50 mg per serving

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe o...

1-Androstene-3Beta-Ol,17-One monograph & interactions

4-Androstene-3Beta-Ol,17-One

Interacts with
8 drugs
50 mg per serving

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe o...

4-Androstene-3Beta-Ol,17-One monograph & interactions

Androsta-3,5-Diene-7,17-Dione

Interacts with
4 drugs
50 mg per serving

Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone,...

Androsta-3,5-Diene-7,17-Dione monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C #40, FD&C Yellow #6. These complete the product’s ingredient list but are not active constituents.

Interaction report

Metha-Quad Extreme by Blackstone Labs Drug Interactions

Want to check YOUR meds against Metha-Quad Extreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
13Drugs
12 Moderate 1 Minor

Ingredients driving the most interactions

Androsterone 9
1-Androstene-3Beta-Ol,17-One 8
Androsta-3,5-Diene-7,17-Dione 4

Individual Drug Interactions

The ingredients in Metha-Quad Extreme interact with 13 drugs. Click any drug to see the details.

3 of the 4 ingredients in Metha-Quad Extreme interact with drugs. Each result below shows which ingredient is responsible. Androsterone 1-Androstene-3Beta-Ol,17-One Androsta-3,5-Diene-7,17-Dione

Each ingredient & the kinds of drugs it affects

For each ingredient in Metha-Quad Extreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Androsterone1 drug type · 9 drugs

Androgens

Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action. Both androsterone and testosterone bind to androgen receptors in various tissues throughout the body, leading to similar physiological effects related to the development and maintenance of male secondary sexual characteristics. When taken together, these compounds can potentially amplify these effects, leading to an increased risk of androgenic side effects, such as acne, hair loss, and changes in libido. Additionally, combining androsterone with testosterone or other androgenic drugs may also affect hormone levels and balance in the body, potentially leading to hormonal imbalances or disruptions in the endocrine system.

Likelihood Possible Evidence C
Androsterone full monograph & interactions

1-Androstene-3Beta-Ol,17-One1 drug type · 8 drugs

Testosterone

Theoretically, taking 1-androsterone with testosterone might increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.
1-Androsterone is converted to 1-testosterone and other androgens upon ingestion.

Likelihood Possible Evidence D
1-Androstene-3Beta-Ol,17-One full monograph & interactions

Androsta-3,5-Diene-7,17-Dione1 drug type · 4 drugs

Aromatase Inhibitors

It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors. This interaction could potentially increase the risk of side effects associated with low estrogen levels or from additive side effects, such as an increased risk of liver toxicity. It is recommended to consult with a healthcare provider before combining Arimistane with other aromatase inhibitors to assess the potential risks and benefits.

Likelihood Probable Evidence C
Androsta-3,5-Diene-7,17-Dione full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Metha-Quad Extreme, from the product label.

Blackstone Labs

See all Blackstone Labs products
Name
Blackstone Labs
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-877-454-6861
Web Address
www.BlackStoneLabs.com
Pharmacist Counseling Corner

Metha-Quad Extreme by Blackstone Labs: Common Questions

Does Metha-Quad Extreme by Blackstone Labs interact with any medications?
Yes. Based on its ingredients, Metha-Quad Extreme has a known interaction with 13 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Metha-Quad Extreme contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is androsterone legal to use in supplements?
No. Androsterone is a controlled anabolic-androgenic steroid that is illegal to sell as a dietary supplement in the U.S. This product should not be sold as a supplement under current law.
Can I take this if I'm using testosterone replacement therapy?
No—not without clearing it with your doctor first. Taking this product alongside testosterone could increase your risk of mood disturbances and cardiovascular, kidney, or liver problems due to additive hormonal effects.
What are the most common side effects reported?
For the 1-androstene and 4-androstene ingredients, the most common reported side effects are bad cholesterol changes (LDL up, HDL down), liver enzyme elevation, and kidney function changes. One study found kidney filtration markers dropped below normal after just 4 weeks of use.
Does this product actually work for building muscle?
The evidence isn't there. All four ingredients are rated insufficient evidence for athletic performance and muscle strength—meaning we don't have reliable proof they work for those purposes.
Is this safe to use while pregnant or breastfeeding?
No. These hormone-altering compounds are possibly unsafe in pregnancy and should not be used while breastfeeding. Hormone exposure could harm a developing baby or a nursing infant.
What is androsta-3,5-diene-7,17-dione supposed to do?
It's believed to inhibit the aromatase enzyme, which controls estrogen production. However, the evidence doesn't establish it reliably works for athletic performance, muscle strength, erectile dysfunction, sexual arousal, or weight loss, and regulators warn against aromatase-inhibitor supplements due to safety concerns.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Metha-Quad Extreme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Metha-Quad Extreme label
Go deeper

The Full Monographs Behind Metha-Quad Extreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Androsterone

Interacts with 9 drugs

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements und...

Read the full Androsterone monograph → Herb & supplement monograph

1-androsterone

Interacts with 8 drugs

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe or effective in quality human studies. It...

Read the full 1-androsterone monograph → Herb & supplement monograph

Arimistane

Interacts with 4 drugs

Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohor...

Read the full Arimistane monograph →
Sources

Sources & How We Checked

Metha-Quad Extreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Androsterone 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Androsterone monograph →

1-androsterone 2 references
  1. Parr MK, Opfermann G, Geyer H, et al. Seized designer supplement named "1-Androsterone": identification as 3ß-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Steroids 2011;76(6):540-7.
  2. Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.

See these in context on the 1-androsterone monograph →

Arimistane 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Arimistane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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