1-androsterone + Methyltestosterone
Methyltestosterone brand names: Metandren, Android 10, Oreton, Testred, Methitest, and others.
1-androsterone has a moderate interaction with Methyltestosterone. Theoretically, taking 1-androsterone with testosterone might increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.
Read the full interaction report1-androsterone and Methyltestosterone
Here is the interaction we found between these two, with the evidence behind it.
TESTOSTERONE
Why this applies to Methyltestosterone
Methyltestosterone falls under TESTOSTERONE — the group 1-androsterone interacts with.
1-Androsterone is converted to 1-testosterone and other androgens upon ingestion.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version. Methyltestosterone is itself an androgen (a male hormone you take by mouth). 1-Androsterone is a prohormone that your body turns into 1-testosterone, which is also androgen-like. So you'd basically be stacking two hormone products on top of each other, and the effects can pile up.
When androgens add together, you may see more of the usual stuff: acne, oily skin, mood swings or irritability, fluid retention, and rising blood pressure. The bigger worry is strain on the liver, since methyltestosterone is already known to be tough on it, plus possible heart and kidney effects. This is a theoretical concern based on how these work, not proven by strong studies, but it's a real reason to be cautious. Please run this by your pharmacist or doctor before combining them.
- Parr MK, Opfermann G, Geyer H, et al. Seized designer supplement named "1-Androsterone": identification as 3ß-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Steroids 2011;76(6):540-7.
- Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
1-androsterone Also Interacts With Other Medications
1-androsterone has 7 moderate known drug interactions in our database — the Methyltestosterone one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 1-androsterone
We haven’t checked that one against 1-androsterone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 1-androsterone. Pick one to open its full report.
See Every Supplement That Interacts With Methyltestosterone
This page covers 1-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methyltestosterone page lists 73 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and 19-nor-dhea (moderate).
By severity: 4 major · 53 moderate · 16 minor.
From our pharmacist’s overview on the Methyltestosterone page
“Liver strain dominates this list, and it warrants real wariness before pairing supplements with methyltestosterone (Android, Testred, Methitest). This oral hormone is already hard on the liver by itself, and 38 of the 73 supplement ingredients on file carry their own liver toxicity, stacking injury on the same organ.”
Reviewed by 2 · Jul 18, 2026
Taking 1-androsterone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 35 real supplement products containing 1-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 1-androsterone. Your product may carry other ingredients that interact with Methyltestosterone too, on top of 1-androsterone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where 1-androsterone and Methyltestosterone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#565 of 1,452 supplements looked up here in the last 7 days
#2,447 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About 1-androsterone
What is 1-androsterone?
- Muscle building
- Increasing strength
- Athletic performance
- Body recomposition
1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe or effective in quality human studies. It can affect hormones and may harm the liver and other organs, so most pharmacists would recommend avoiding it.
Other Drugs & 1-androsterone
Browse every other medication we’ve checked against 1-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
7 interactions
No interaction 2,822 drugs checked — show the list
We also checked 1-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,822 medications checked with no known interaction — see the full 1-androsterone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking 1-androsterone and Methyltestosterone Together: Common Questions
Can you take 1-androsterone with Methyltestosterone?
How serious is the 1-androsterone and Methyltestosterone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.