Medication interaction hub

What Supplements Interact with Ethacrynic Acid?

Ethacrynic Acid brand name: Edecrin. Every interaction below applies to the brands too.

201 Interactions 7 Major 170 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ethacrynic Acid? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ethacrynic Acid against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ethacrynic acid (Edecrin) is a potent loop diuretic, a water pill used to pull off serious fluid buildup, and its supplement list deserves genuine care, starting with the seven entries rated major. Most of the 201 interactions on file either stack with its blood-pressure-lowering effect, risking dizziness or faintness, or work against it and undo the fluid control you take it for. A smaller set, activated charcoal among them, can soak up the oral dose before it works.

Among the major entries, lithium supplements can climb to toxic levels because this diuretic slows how the kidneys clear lithium, and yellow dock can deepen the potassium loss ethacrynic acid already causes, which matters for the heart. The other 194 split into 170 moderate and 24 minor, and most are the additive blood-pressure kind, worth watching but usually manageable.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 170 Minor 24 No known interaction 1,251

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ethacrynic Acid: Top Interactions at a Glance

The Ethacrynic Acid supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 201 interacting ingredients — plus 1,251 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ethacrynic Acid Combinations Today

The Ethacrynic Acid + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Foxglove + Ethacrynic Acidi

Theoretically, concomitant use of potassium depleting diuretics increases the risk of cardiac glycoside toxicity.

Read the full interaction Moderate Likelihood Possible Quassia + Ethacrynic Acidi

Overuse of quassia might compound diuretic-induced potassium loss.

Read the full interaction Moderate Likelihood Possible Uzara + Ethacrynic Acidi

Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassium depletion.

Read the full interaction Moderate Likelihood Possible Calotropis + Ethacrynic Acidi

Theoretically, concomitant use of calotropis and potassium depleting diuretics can increase the risk of cardiac glycoside toxicity due to potassium depletion.

Read the full interaction Moderate Likelihood Possible Black Root + Ethacrynic Acidi

Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretic...

Read the full interaction Moderate Likelihood Possible Lovage + Ethacrynic Acidi

Theoretically, lovage root might interfere with diuretic therapy due to its aquaretic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Ethacrynic Acid

All 1,452 ingredients in our database, ranked by severity — 201 with a Ethacrynic Acid interaction on file and 1,251 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ethacrynic Acid?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Foxglove with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium depleting diuretics increases the risk of cardiac glycoside toxicity.

Full Foxglove + Ethacrynic Acid answer

Can you take Quassia with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of quassia might compound diuretic-induced potassium loss.

Full Quassia + Ethacrynic Acid answer

Can you take Uzara with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassi...

Full Uzara + Ethacrynic Acid answer

Can you take Calotropis with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of calotropis and potassium depleting diuretics can increase the risk of cardiac glycoside toxicity due to po...

Full Calotropis + Ethacrynic Acid answer

Can you take Black Root with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassiu...

Full Black Root + Ethacrynic Acid answer

Can you take Apple Cider Vinegar with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.

Full Apple Cider Vinegar + Ethacrynic Acid answer

Can you take Artichoke with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.

Full Artichoke + Ethacrynic Acid answer

Can you take Asafoetida with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that asafoetida has hypotensive effects.

Full Asafoetida + Ethacrynic Acid answer

Can you take Ash with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ash seed with antihypertensive drugs might have additive blood pressure lowering effects.

Full Ash + Ethacrynic Acid answer

Can you take Ashwagandha with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Full Ashwagandha + Ethacrynic Acid answer

Can you take Asparagus with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Full Asparagus + Ethacrynic Acid answer

Can you take Asparagus Racemosus with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Full Asparagus Racemosus + Ethacrynic Acid answer

Can you take Baikal Skullcap with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotensi...

Full Baikal Skullcap + Ethacrynic Acid answer

Can you take Basil with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.

Full Basil + Ethacrynic Acid answer

Can you take Berberine with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Ethacrynic Acid answer

Can you take Beta-glucans with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.

Full Beta-glucans + Ethacrynic Acid answer

Can you take Betony with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, betony might have additive effects with blood pressure lowering drugs due to hypotensive activity of the glycosides found in...

Full Betony + Ethacrynic Acid answer

Can you take Black Hellebore with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium depleting diuretics and black hellebore can increase the risk of cardiac glycoside toxicity due...

Full Black Hellebore + Ethacrynic Acid answer

Can you take Black Seed with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Ethacrynic Acid answer

Can you take Black Tea with Ethacrynic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.

Full Black Tea + Ethacrynic Acid answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ethacrynic Acid is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ethacrynic Acid, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ethacrynic Acid sits in 4 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Ethacrynic Acid through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Ethacrynic Acid through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ethacrynic Acid through this category.

Loop Diuretics 2 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

2 of the supplement ingredients on this page reach Ethacrynic Acid through this category.

About Ethacrynic Acid

Ethacrynic acid is a diuretic ("water pill") used to treat excess fluid buildup caused by heart, kidney, liver, or cancer conditions.

Generic name: Ethacrynic Acid  ·  Brand name: Edecrin.

See the full Ethacrynic Acid drug information

Related: does Ethacrynic Acid deplete any nutrients?

Ethacrynic Acid has 8 reported nutrient associations in the research literature — see the Ethacrynic Acid nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ethacrynic Acid

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ethacrynic Acid.

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Products that contain Ethacrynic Acid-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Ethacrynic Acid.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Ethacrynic Acid & Supplements: Common Questions

What supplements interact with Ethacrynic Acid?
Our database currently documents 201 ingredients with a known Ethacrynic Acid interaction (7 major, 170 moderate, 24 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 201. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Ethacrynic Acid supplement interactions are the most serious?
The 7 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Lithium — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ethacrynic Acid?
Plenty of supplements coexist fine with Ethacrynic Acid; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Edecrin have the same supplement interactions as Ethacrynic Acid?
Yes — Edecrin all contain Ethacrynic Acid, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ethacrynic Acid deplete any vitamins or nutrients?
It might — Ethacrynic Acid has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ethacrynic Acid nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ethacrynic Acid and my other medications?
This page covers Ethacrynic Acid against supplements and herbal ingredients. Checking Ethacrynic Acid against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ethacrynic Acid drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.