Drug & supplement interaction

Beet + Ethacrynic Acid

Ethacrynic Acid brand name: Edecrin.

Minor Interaction
Medically reviewed by · Updated November 2023
The bottom line Minor

Beet has a minor interaction with Ethacrynic Acid. Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceA
What do Severity, Likelihood & Evidence mean?
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Interaction report

Beet and Ethacrynic Acid

Here is the interaction we found between these two, with the evidence behind it.

Minor

Antihypertensive Drugs

Why this applies to Ethacrynic Acid

Ethacrynic Acid falls under Antihypertensive Drugs — the group Beet interacts with.

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.
Severity Minor Likelihood Possible Evidence A

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: ethacrynic acid (Edecrin) is a strong water pill that pulls extra salt and fluid out of your body, and one of its side effects is lowering blood pressure. Beets, especially beetroot juice, carry natural nitrates that can relax blood vessels a little. Put them together and there's a theoretical chance your blood pressure dips slightly more than usual, which could leave you feeling lightheaded or dizzy, particularly when standing up quickly.

Honestly, though, the evidence shows this effect is mild and short-lived, if it happens at all. Eating beets at meals is very unlikely to be a problem. If you use concentrated beetroot juice or shots regularly, it's worth a quick chat with your pharmacist or doctor. Don't change your ethacrynic acid on your own.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Beet Also Interacts With Other Medications

Beet has 643 moderate, 217 minor known drug interactions in our database — the Ethacrynic Acid one above is one of them. If you take anything else, check it against the full list below.

Moderate 643 Minor 217 No known interaction 1,970 (incl. Ethacrynic Acid)
Taking anything else?

Check Another of Your Medications Against Beet

Covers the 2,830 medications we’ve checked against Beet. Pick one to open its full report.

From our Q&A

Questions About Beet or Ethacrynic Acid

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Beet or Ethacrynic Acid, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ethacrynic Acid

This page covers Beet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ethacrynic Acid page lists 201 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 170 moderate · 24 minor.

From our pharmacist’s overview on the Ethacrynic Acid page

“Ethacrynic acid (Edecrin) is a potent loop diuretic, a water pill used to pull off serious fluid buildup, and its supplement list deserves genuine care, starting with the seven entries rated major. Most of the 201 interactions on file either stack with its blood-pressure-lowering effect, risking dizziness or faintness, or work against…”

Reviewed by 2 · Jul 18, 2026

Open the Ethacrynic Acid interaction page

One more smart check

Taking Beet as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,785 real supplement products containing Beet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beet. Your product may carry other ingredients that interact with Ethacrynic Acid too, on top of Beet — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Beet and Ethacrynic Acid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beet
Top 5%

#38 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ethacrynic Acid
Top half

#1,000 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Beet

What is Beet?

Beet
  • High blood pressure
  • Exercise and athletic performance
  • Heart and circulation support
  • General antioxidant/anti-inflammatory support
  • Liver and digestive support

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but supplement effects are modest and not a substitute for prescribed treatment, so talk with your pharmacist or doctor before relying on it.

Read the full Beet monograph & all interactions
Medication

About Ethacrynic Acid

What Is Ethacrynic Acid Used For?

Brand name: Edecrin

Ethacrynic acid tablets (sold as Edecrin and Ethacrynic Acid) are used to treat edema — excess fluid that builds up in the body — when other, milder diuretics aren't strong enough. It treats edema related to congestive heart failure, cirrhosis of the liver, and kidney disease, including nephrotic syndrome (a kidney condition that causes protein loss and swelling).

It is also used for short-term management of fluid buildup from malignancy (cancer-related ascites), idiopathic edema (swelling with no clear cause), and lymphedema (swelling from a blocked lymph system). In hospitalized children (not infants), it may be used short-term for edema related to congenital heart disease or nephrotic syndrome.

See full Ethacrynic Acid drug information
Keep checking

Other Drugs & Beet

Browse every other medication we’ve checked against Beet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
643Moderate
217Minor
1,969No known interaction
643 Moderate 217 Minor 1,969 No interaction
Moderate

643 interactions

Showing 60 of 643 moderate interactions — see all 643 on the Beet page.

Minor

217 interactions

Showing 60 of 217 minor interactions — see all 217 on the Beet page.

No interaction 1,969 drugs checked — show the list

We also checked Beet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,969 medications checked with no known interaction — see the full Beet list.

See the full Beet interactions page
See every supplement checked against Ethacrynic Acid, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Beet monograph › Uses, safety, and every drug interaction in one place Ethacrynic Acid supplement interactions › Every supplement checked against Ethacrynic Acid, ranked by severity Ethacrynic Acid drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Beet and Ethacrynic Acid Together: Common Questions

Can you take Beet with Ethacrynic Acid?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Beet and Ethacrynic Acid interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ethacrynic Acid and Beet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.