Pedunculate Oak Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Pedunculate Oak interacts with medications. The heart of this page is the interaction list — every drug Pedunculate Oak is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Pedunculate Oak is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Pedunculate Oak against your medication
Add one medicationDrugs that interact with Pedunculate Oak
0 medications have a known interaction with Pedunculate Oak, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Pedunculate Oak. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Pedunculate Oak combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Pedunculate Oak: Uses, Safety & Side Effects
Pedunculate oak bark is a traditional astringent remedy used mainly for mild diarrhea, sore throat, and skin or anal irritation, thanks to its high tannin content. Evidence comes mostly from tradition and laboratory studies rather than strong human trials, so use it short-term and check with a pharmacist or doctor before trying it.
- Scientific name
- Quercus robur
- Family
- Fagaceae
- Part used
- Bark, and sometimes the galls and acorns
- Common forms
- Dried bark for tea or decoction, liquid extracts, and bark powder for compresses, baths, or gargles
- Diarrhea
- Sore throat and mouth inflammation
- Skin irritation and minor wounds
- Hemorrhoids
- Excessive sweating
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used short-term for minor complaints, but the high tannin content can irritate the stomach and is not meant for long-term use.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Pedunculate oak (Quercus robur) is a large, long-lived tree in the beech family. It is native to Europe and parts of western Asia, where it grows in forests, parks, and hedgerows. It is also called the English oak or common oak.
In traditional European herbal medicine, the part most often used is the bark of young branches, which is dried and made into teas, washes, gargles, or baths. Oak bark is rich in plant compounds called tannins, which give it a strong drying, or "astringent," quality.
People have used oak bark preparations for centuries to ease mild diarrhea, soothe sore throats and inflamed gums, and treat minor skin problems and hemorrhoids. Today it is sold as a dried herb and in liquid extracts.
How it works
The main active compounds in oak bark are tannins (such as ellagitannins and gallotannins) along with other plant chemicals. Tannins bind to proteins and cause tissues to tighten and contract, which is what "astringent" means.
This tightening effect may help reduce minor oozing, form a protective layer over irritated skin or mucous membranes, and slow fluid loss in the gut, which is the proposed reason it has been used for diarrhea and inflamed tissues. Tannins also show antimicrobial and antioxidant activity in laboratory tests.
Keep in mind that much of this understanding is based on test-tube and animal research. How well these effects translate to real benefits in people is not well established.
Does Pedunculate Oak work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Pedunculate Oak, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 6 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Alcohol-related liver disease
It is unclear if pedunculate oak wood extract is beneficial in patients with alcohol-related liver disease.
Insufficient Reliable Evidence To Rate Athletic performance
It is unclear if pedunculate oak wood extract improves athletic performance in amateur athletes.
Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
It is unclear if pedunculate oak wood extract is beneficial in patients with CFS.
Insufficient Reliable Evidence To Rate Lymphedema
It is unclear if oral pedunculate oak wood extract is beneficial in patients with primary lymphedema.
Insufficient Reliable Evidence To Rate Postoperative recovery
It is unclear if oral pedunculate oak wood extract is beneficial for postoperative recovery in patients undergoing hysterectomy.
Insufficient Reliable Evidence To Rate Wound healing
Although there has been interest in using topical pedunculate oak for wound healing, there is insufficient reliable information about the clinical effects of pedunculate oak for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
When used short-term and as directed, oak bark is generally considered fairly safe for most adults. However, the high tannin content means it should not be used for long periods or in large amounts.
Use extra caution if you have stomach or bowel problems, ongoing diarrhea, kidney or liver disease, or open or weeping skin conditions over large areas. Do not use oak bark baths if you have large skin injuries, fever, or serious heart problems without medical advice. Diarrhea that lasts more than a couple of days, or that comes with fever or blood, needs a doctor's evaluation rather than self-treatment.
Pregnancy and breastfeeding: There is not enough reliable safety information for these times, so it is best to avoid oak bark during pregnancy and while breastfeeding unless your doctor specifically recommends it.
Always talk with a pharmacist or doctor before using oak bark, especially if you take other medicines or have a health condition.
Side effects
Because of its tannins, oak bark taken by mouth can cause stomach upset, nausea, or constipation, especially with strong preparations or long-term use. Very high amounts of tannins may stress the liver or kidneys.
Applied to the skin, it can sometimes cause irritation or allergic reactions. Full-body baths covering broken skin could allow more tannin to be absorbed. Stop use and seek care if you notice signs of an allergic reaction such as rash, swelling, or trouble breathing.
Pedunculate Oak: Reported Adverse Effects
Documented safety reports on Pedunculate Oak from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, pedunculate oak seems to be well-tolerated. No adverse effects have been reported for patients taking a specific extract of pedunculate oak wood (Robuvit, Horphag Research Ltd.).
Most Common Adverse Effects:
Topically: Allergy in sensitive individuals.
Allergic rhinitis (hay fever) Immunologic
Topically, allergy to pedunculate oak pollen is common.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no single standardized dose of pedunculate oak bark that applies to everyone, and amounts vary by product and how it is used (tea, gargle, wash, or bath).
The best approach is to follow the directions on the product label and not exceed them. Traditional use generally limits internal use to a few days only. For mouth, throat, or skin uses, oak bark is typically used as a diluted rinse or wash rather than swallowed.
Because preparations differ in strength, ask a pharmacist or doctor to help you choose a product and an appropriate amount, and stop use if your symptoms do not improve quickly.
Pedunculate Oak & Pregnancy
Pedunculate Oak & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 references that drive our Pedunculate Oak monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Weber RW. Allergen of the Month--English Oak. Ann Allergy Asthma Immunol. 2015 Nov;115(5):A13. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Pedunculate Oak: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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