Chitosan + Chlorthalidone
Chlorthalidone brand names: Hygroton, Thalitone.
We found no known interaction between Chitosan and Chlorthalidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Chlorthalidone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Chitosan and Chlorthalidone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Chlorthalidone and Chitosan in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Chitosan safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Chlorthalidone
Interactions in our licensed database are recorded against drug classes, not just single drug names. Chlorthalidone is filed under 5 classifications — including thiazide diuretics, diuretic drugs, antihypertensive drugs. Chitosan has documented interactions with 2 drug classes — the most serious being acyclovir (zovirax) (moderate) and warfarin (coumadin) (moderate) — and none of Chlorthalidone’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Chitosan Does Interact With Other Medications
Chitosan has 3 moderate known drug interactions in our database — Chlorthalidone isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Chitosan
We haven’t checked that one against Chitosan yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Chitosan. Pick one to open its full report.
Some Chlorthalidone Products Have a Food Rule — Chitosan Should Not Break It
At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take Chitosan on an empty stomach out of habit, keep them separate — and take Chlorthalidone with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Chlorthalidone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Hypertension The initial recommended dose is 15 mg once daily with food.
From the Dosage and Administration section of the FDA label we read for Chlorthalidone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Chlorthalidone Is Prescribed For, and What Chitosan Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Chlorthalidone is a prescription medicine with approved uses on its FDA label. Chitosan is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Chlorthalidone is prescribed for: Chlorthalidone is used to treat high blood pressure (hypertension) in adults. Lowering blood pressure reduces the risk of serious cardiovascular events, especially strokes and heart attacks. It can be used alone or combined with other blood pressure medicines. Chlorthalidone is also used as an add-on treatment for edema (fluid buildup) caused by heart failure, liver cirrhosis, and kidney conditions including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.
Read the rest of what Chlorthalidone is prescribed for
Thalitone is additionally indicated for edema associated with heart failure, liver cirrhosis, and renal disease including nephrotic syndrome.
Chitosan has been studied for:
-
Hypertension Natural Medicines rates the evidence for Chitosan: Possibly Effective Read what the research shows
Chitosan for hypertension
Substituting table salt with a chitosan-containing table salt may reduce blood pressure in patients with hypertension.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Chlorthalidone on your own; if you are taking Chitosan for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Chitosan or Chlorthalidone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Chitosan or Chlorthalidone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Switching From HCTZ To Chlorthalidone Due To Side Effects Of Hair Loss And Dry Mouth ›
- Can You Split Edarbi Tablets In Half? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Chlorthalidone
This page covers Chitosan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorthalidone page lists 222 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Dolomite (major) and Lithium (major).
By severity: 8 major · 190 moderate · 24 minor.
From our pharmacist’s overview on the Chlorthalidone page
“Chlorthalidone (Hygroton, Thalitone) lowers blood pressure by helping the kidneys shed salt and water, and that mechanism makes its supplement interactions worth genuine care. Most of the 222 ingredients on file either add to its blood-pressure-lowering effect or act as diuretics themselves, so pressure or potassium can fall further th…”
Reviewed by 2 · Jul 18, 2026
Taking Chitosan as Part of a Dietary Supplement Product? Check It for Interactions
We hold 167 real supplement products containing Chitosan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chitosan. Even though Chitosan itself has no known interaction with Chlorthalidone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Chitosan and Chlorthalidone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#488 of 1,452 supplements looked up here in the last 7 days
#1,449 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chitosan reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chitosan and Chlorthalidone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Chitosan
What is Chitosan?
- Weight management
- Lowering cholesterol
- Wound care
- General digestive supplement
Chitosan is a fiber-like substance made from the shells of shrimp, crabs, and other shellfish, often marketed for weight loss and cholesterol. The evidence for these benefits is weak, and any effects appear small at best. It is generally well tolerated for short-term use, but people with shellfish allergies and those who are pregnant or breastfeeding should be cautious.
Shells of crustaceans (the source of chitin, which is processed into chitosan) · Capsules, tablets, powder
An interaction check asks whether these two react with each other — it does not ask whether Chitosan is a good idea for someone in your situation. Here is what our Chitosan record says about it on its own.
Chitosan: dosing
There is no official standardized dose for chitosan, and amounts used in studies have varied widely. Because of this, it is best to follow the directions on the product label and not exceed them.Chitosan is often taken with meals and a full glass of water.
From our Chitosan monograph — the full record covers uses, side effects and every documented interaction.
About Chlorthalidone
What Is Chlorthalidone Used For?
Brand names: Hygroton, Thalitone
Chlorthalidone is used to treat high blood pressure (hypertension) in adults. Lowering blood pressure reduces the risk of serious cardiovascular events, especially strokes and heart attacks. It can be used alone or combined with other blood pressure medicines.
Chlorthalidone is also used as an add-on treatment for edema (fluid buildup) caused by heart failure, liver cirrhosis, and kidney conditions including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Thalitone is additionally indicated for edema associated with heart failure, liver cirrhosis, and renal disease including nephrotic syndrome.
Most-Reported Side Effects for Chlorthalidone
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Chitosan
Browse every other medication we’ve checked against Chitosan — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
3 interactions
No interaction 2,826 drugs checked — show the list
We also checked Chitosan against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Candesartan Cilexetil ›
Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Chitosan list.
Chitosan References
The 17 references that drive our Chitosan monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Jing SB, Li L, Ji D, et al. Effect of chitosan on renal function in patients with chronic renal failure. J Pharm Pharmacol 1997;49:721-3. PubMed
- Pittler MH, Abbot NC, Harkness EF, Ernst E. Randomized, double-blind trial of chitosan for body weight reduction. Eur J Clin Nutr 1999;53:379-81. PubMed
- Ho SC, Tai ES, Eng PH, et al. In the absence of dietary surveillance, chitosan does not reduce plasma lipids or obesity in hypercholesterolaemic obese Asian subjects. Singapore Med J 2001;42:6-10.
- Bokura H, Kobayashi S. Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 2003;57:721-5. PubMed
- Mhurchu CN, Poppitt SD, McGill AT, et al. The effect of the dietary supplement, Chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults. Int J Obes Relat Metab Disord 2004;28:1149-56. PubMed
- Huang SS, Sung SH, Chiang CE. Chitosan potentiation of warfarin effect. Ann Pharmacother 2007;41:1912-4. PubMed
- Tsai, G. J. and Su, W. H. Antibacterial activity of shrimp chitosan against Escherichia coli. J Food Prot. 1999;62(3):239-243. PubMed
- Wuolijoki, E., Hirvela, T., and Ylitalo, P. Decrease in serum LDL cholesterol with microcrystalline chitosan. Methods Find.Exp Clin Pharmacol. 1999;21(5):357-361. PubMed
- Nelson, J. L., Alexander, J. W., Gianotti, L., Chalk, C. L., and Pyles, T. Influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutrition 1994;10(1):32-36.
- Schiller RN, Barrager E, Schauss EA, and et al. A randomized, double-blind, placebo-controlled study examining the effects of a rapidly soluble chitosan dietary supplement on weight loss and body composition in overweight and mildly obese individuals. J
- Koide, S. S. Chitin-chitosan: properties, benefits and risks. Nutrition Research 1998;8(6):1091-1101. DOI
- Maezaki Y, Tsuji K, Nakawa, and et al. Hypocholesterolaemic effect of chitosan in adult males. Biosc Biochem Biotech 1993;57:1439-1444.
- Kubbinga M, Nguyen MA, Staubach P, et al. The influence of chitosan on the oral bioavailability of acyclovir-a comparative bioavailability study in humans. Pharm Res 2015;32(7):2241-9. PubMed
- Jull AB, Ni Mhurchu C, Bennett DA, et al. Chitosan for overweight or obesity. Cochrane Database Syst Rev 2008;(3):CD003892. PubMed
- Schmidl D, Werkmeister R, Kaya S, et al. A Controlled, Randomized Double-Blind Study to Evaluate the Safety and Efficacy of Chitosan-N-Acetylcysteine for the Treatment of Dry Eye Syndrome. J Ocul Pharmacol Ther. 2017;33(5):375-382.
- Moraru C, Mincea MM, Frandes M, Timar B, Ostafe V. A meta-analysis on randomised controlled clinical trials evaluating the effect of the dietary supplement chitosan on weight loss, lipid parameters and blood pressure. Medicina (Kaunas). 2018;54(6):109. PubMed
- García MA, Hensler G, Al-Gousous J, Pielenhofer J, Wagner M, Lennernäs H, Langguth P. Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus. Drug Metab Pharmacokinet. 2023;49:100491. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Chlorthalidone Is Linked to Lower Levels of 8 Nutrients
Natural Medicines records Chlorthalidone as a medicine that can lower these. This is not an interaction with Chitosan — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Chlorthalidone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Chitosan and Chlorthalidone Together: Common Questions
Is it safe to take Chitosan with Chlorthalidone?
Do Chitosan and Chlorthalidone have any of the same side effects?
Should I take Chitosan and Chlorthalidone at the same time of day?
Are Chitosan and Chlorthalidone used for the same thing?
How was the Chitosan and Chlorthalidone combination checked?
Does Chitosan interact with any other medications?
Does Chlorthalidone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Chlorthalidone and Chitosan?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.